Patents by Inventor Agneta PRASSE

Agneta PRASSE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human trypsinogen with reduced autoactivation and its use in an immunoassay
    Patent number: 9976135
    Abstract: The present invention relates to a polypeptide consisting of or comprising a variant of human trypsinogen-1, comprising the substitutions: amino acid residue E64 is replaced with an amino acid residue comprising a positively charged side chain, amino acid residue K123 is replaced with an amino acid residue comprising an aliphatic side chain and amino acid residues Y139 and D147 are replaced with a glutamine or asparagine residue, and wherein said variant is further characterized in that: an amino acid residue selected from E16, E17 and E142 is replaced with an amino acid residue comprising an aliphatic side chain, and/or amino acid residue N18 is replaced with a histidine residue, and/or amino acid residue R107 is replaced with a lysine residue, and/or amino acid residue D138 is replaced with an amino acid residue comprising a positively charged side chain, and wherein said variant is cleavable into a polypeptide having a native-like enzymatic activity when compared to human trypsin-1.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: May 22, 2018
    Assignee: LIFE SCIENCE INKUBATOR GMBH
    Inventors: Karin Büttner, Agneta Prasse, Thole Zuchner
  • PHOSPHORESCENCE-BASED HYDROGEN PEROXIDE ASSAY FOR THE DETECTION OF HYDROGEN PEROXIDE IN HUMAN SERUM AND WATER SAMPLES
    Publication number: 20160376630
    Abstract: The present invention relates to a method for determining an amount of a peroxide in a sample, wherein the method comprises the steps of: —providing a sample, —contacting the sample with a terbium(III) benzene dicarboxylic acid complex, and —determining the luminescence of the terbium(III) benzene dicarboxylic acid complex.
    Type: Application
    Filed: July 1, 2014
    Publication date: December 29, 2016
    Applicant: UNIVERSITAT LEIPZIG
    Inventors: Thomas KREISING, Agneta PRASSE, Kristin ZCHARNACK, Thole ZUCHNER
  • HUMAN TRYPSINOGEN WITH REDUCED AUTOACTIVATION AND ITS USE IN AN IMMUNOASSAY
    Publication number: 20160237419
    Abstract: The present invention relates to a polypeptide consisting of or comprising a variant of human trypsinogen-1, comprising the substitutions: amino acid residue E64 is replaced with an amino acid residue comprising a positively charged side chain, amino acid residue K123 is replaced with an amino acid residue comprising an aliphatic side chain and amino acid residues Y139 and D147 are replaced with a glutamine or asparagine residue, and wherein said variant is further characterized in that: an amino acid residue selected from E16, E17 and E142 is replaced with an amino acid residue comprising an aliphatic side chain, and/or amino acid residue N18 is replaced with a histidine residue, and/or amino acid residue R107 is replaced with a lysine residue, and/or amino acid residue D138 is replaced with an amino acid residue comprising a positively charged side chain, and wherein said variant is cleavable into a polypeptide having a native-like enzymatic activity when compared to human trypsin-1.
    Type: Application
    Filed: September 25, 2014
    Publication date: August 18, 2016
    Applicant: UNIVERSITAT LEIPZIG
    Inventors: Karin BUTTNER, Agneta PRASSE, Thole ZUCHNER