Patents by Inventor Agostino Marasco

Agostino Marasco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydantoin derivatives useful as Kv3 inhibitors
    Patent number: 11583527
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: February 21, 2023
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • Compounds
    Patent number: 11541052
    Abstract: The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: January 3, 2023
    Assignee: Autifony Therapeutics Limited
    Inventors: Giuseppe Alvaro, Agostino Marasco
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20220054490
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: November 2, 2021
    Publication date: February 24, 2022
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • Hydantoin derivatives useful as Kv3 inhibitors
    Patent number: 11197859
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: December 14, 2021
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • Triazoles as Kv3 inhibitors
    Patent number: 11180461
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: November 23, 2021
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
  • NOVEL COMPOUNDS
    Publication number: 20210276985
    Abstract: Disclosed is a compound of formula (I): wherein R1 is H or methyl, R2 and R3 are both methyl, or R2 and R3, together with the carbon atom to which they are attached, are a spirocyclopropyl ring, R4 is methyl or ethyl, R5 is H or methyl, or R4 and R5, together with the carbon atom to which they are attached, form a C3-C4 spiro carbocyclyl. Also disclosed are methods for treating and/or preventing one or more diseases or disorders comprising administering to a subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, solvate and/or derivative thereof. Additionally, methods using a compound of formula (I) to manufacture medicaments are provided.
    Type: Application
    Filed: April 15, 2021
    Publication date: September 9, 2021
    Inventors: Giuseppe Alvaro, Agostino Marasco
  • Compounds
    Patent number: 10934278
    Abstract: The present invention provides compounds of the formula (I) and their use as Kv3 modulators.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: March 2, 2021
    Assignee: Autifony Therapeutics Limited
    Inventors: Giuseppe Alvaro, Agostino Marasco, Guido Marconi
  • NOVEL COMPOUNDS
    Publication number: 20210023084
    Abstract: The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: September 23, 2020
    Publication date: January 28, 2021
    Inventors: Giuseppe ALVARO, Agostino MARASCO
  • HYDANTOIN MODULATORS OF KV3 CHANNELS
    Publication number: 20200377485
    Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: December 16, 2016
    Publication date: December 3, 2020
    Inventors: Giuseppe ALVARO, Agostino MARASCO, Dieter HAMPRECHT, Anne DECOR
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20200360379
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 19, 2020
    Inventors: Giuseppe ALVARO, Paolo DAMBRUOSO, Simona TOMMASI, Anne DECOR, Charles LARGE, Agostino MARASCO
  • Compounds
    Patent number: 10835534
    Abstract: The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: November 17, 2020
    Assignee: Autifony Therapeutics Limited
    Inventors: Giuseppe Alvaro, Agostino Marasco
  • NOVEL COMPOUNDS
    Publication number: 20200179385
    Abstract: The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: December 23, 2019
    Publication date: June 11, 2020
    Inventors: Giuseppe ALVARO, Agostino MARASCO
  • TRIAZOLES AS KV3 INHIBITORS
    Publication number: 20200172496
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Application
    Filed: February 7, 2020
    Publication date: June 4, 2020
    Inventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
  • IMIDAZOLIDINEDIONE DERIVATIVES
    Publication number: 20200163964
    Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
    Type: Application
    Filed: January 30, 2020
    Publication date: May 28, 2020
    Inventors: Giuseppe ALVARO, Anne DECOR, Stefano FONTANA, Dieter HAMPRECHT, Charles LARGE, Agostino MARASCO
  • Imidazolidinedione derivatives
    Patent number: 10632118
    Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: April 28, 2020
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
  • Triazoles as Kv3 inhibitors
    Patent number: 10611735
    Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: April 7, 2020
    Assignee: Autifony Therapeutics Limited
    Inventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
  • Compounds
    Patent number: 10555945
    Abstract: The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: February 11, 2020
    Assignee: Autifony Therapeutics Limited
    Inventors: Giuseppe Alvaro, Agostino Marasco
  • HYDANTOIN MODULATORS OF KV3 CHANNELS
    Publication number: 20200039970
    Abstract: The invention provides the compound of formula (I): Said compound bein-ganinhibitor of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: December 15, 2017
    Publication date: February 6, 2020
    Inventors: Giuseppe ALVARO, Agostino MARASCO
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20190192516
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: February 26, 2019
    Publication date: June 27, 2019
    Inventors: Giuseppe ALVARO, Paolo DAMBRUOSO, Simona TOMMASI, Anne DECOR, Charles LARGE, Agostino MARASCO
  • NOVEL COMPOUNDS
    Publication number: 20190161479
    Abstract: The present invention provides compounds of the formula (I) and their use as Kv3 modulators.
    Type: Application
    Filed: July 28, 2017
    Publication date: May 30, 2019
    Inventors: Giuseppe ALVARO, Agostino MARASCO, Guido MARCONI