Patents by Inventor Aharon Blank
Aharon Blank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230026678Abstract: A dendrimer including a ring core moiety, a paramagnetic group, a linking moiety and a branching moiety for continuously probing and quantifying an analyte is provided together with methods, kits and devices for performing sensitive, accurate and durable measurements.Type: ApplicationFiled: November 18, 2020Publication date: January 26, 2023Inventors: Aharon BLANK, Jens ANDERS, José VIDAL GANCEDO, Vega LLOVERAS MONSERRAT
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Publication number: 20220155243Abstract: A microwave device comprises: a cavity containing a crystal having paramagnetic defects, and being responsive to light; a magnetic field source for applying magnetic field to the cavity and the crystal; and a light source for generating a pump light beam directed to the crystal and having a frequency selected to induce inversion of spin energy levels of the crystal.Type: ApplicationFiled: November 18, 2021Publication date: May 19, 2022Applicant: Technion Research & Development Foundation LimitedInventors: Aharon BLANK, Alexander SHERMAN
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Publication number: 20210356543Abstract: A method for the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also disclosed.Type: ApplicationFiled: June 21, 2021Publication date: November 18, 2021Inventors: Aharon Blank, Itai Katz, Akiva Feintuch
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Patent number: 11041928Abstract: A method tor the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.Type: GrantFiled: June 3, 2020Date of Patent: June 22, 2021Assignees: Technion Research & Development Foundation Limited, Yeda Research and Development Co. Ltd.Inventors: Aharon Blank, Itai Katz, Akiva Feintuch
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Publication number: 20200341093Abstract: A method tor the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.Type: ApplicationFiled: June 3, 2020Publication date: October 29, 2020Inventors: Aharon BLANK, Itai KATZ, Akiva FEINTUCH
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Patent number: 10722138Abstract: Electron paramagnetic resonance (EPR) systems and methods for transcutaneous oxygen monitoring (TCOM) and subcutaneous oxygen monitoring (SCOM) are provided herein. Optionally, the EPR systems provided herein can be portable and/or handheld to facilitate EPR oximetry in clinical environments.Type: GrantFiled: June 11, 2015Date of Patent: July 28, 2020Assignee: Technion Research & Development Foundation LimitedInventors: Aharon Blank, Periannan Kuppusamy, Ahmad Rizwan
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Patent number: 10718840Abstract: A method for the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.Type: GrantFiled: June 26, 2016Date of Patent: July 21, 2020Assignees: Technion Research & Development Foundation Limited, Yeda Research and Development Co. Ltd.Inventors: Aharon Blank, Itai Katz, Akiva Feintuch
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Publication number: 20180180696Abstract: A method for the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.Type: ApplicationFiled: June 26, 2016Publication date: June 28, 2018Inventors: Aharon BLANK, Itai KATZ, Akiva FEINTUCH
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Publication number: 20170105651Abstract: Electron paramagnetic resonance (EPR) systems and methods for transcutaneous oxygen monitoring (TCOM) and subcutaneous oxygen monitoring (SCOM) are provided herein. Optionally, the EPR systems provided herein can be portable and/or handheld to facilitate EPR oximetry in clinical environments.Type: ApplicationFiled: June 11, 2015Publication date: April 20, 2017Inventors: Aharon BLANK, Periannan KUPPUSAMY, Ahmad RIZWAN
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Patent number: 9194922Abstract: A resonator system for electron spin resonance (ESR) is disclosed. The resonator system comprises: a generally planar resonator layer defining an open-loop gapped by a non-conductive gap in the layer, and a microwave feed, positioned configured for transmitting microwave to the resonator layer such as to concentrate, with a quality factor of at least 100, a magnetic field within an effective volume of less than 1 nL above the layer.Type: GrantFiled: October 18, 2011Date of Patent: November 24, 2015Assignee: Technion Research & Development Foundation LimitedInventors: Aharon Blank, Ygal Twig
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Patent number: 8766634Abstract: A device of estimating a dose of ionizing radiation absorbed in an intra bone volume. The device comprises a static magnetic field source adapted to generate a substantially static magnetic field in a probing space having a volume of less than 2 cubic millimeter (mm3), the probing space being placed in front of a distal end of static magnetic field source, a micro resonator mounted in adjacent to the distal end, and at least one transmission line which feeds the resonator so as to generate an microwave magnetic field at the probing space and to transmit a signal returned from said microwave magnetic field and indicative of radiation induced paramagnetic defects in said probing space so as to allow a spectrometer to compute a dose of ionizing radiation absorbed in a portion of a bone placed in the probing space according to an analysis of the signal. The static magnetic field source being sized and shaped to maneuver the probing space to overlap with an intra bone volume of the bone.Type: GrantFiled: April 15, 2010Date of Patent: July 1, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Aharon Blank, Ygal Twig
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Patent number: 8461836Abstract: A device for ex situ magnetic resonance analysis is disclosed. The device comprises a static magnetic field unit (12) for generating a generally cylindrically symmetric static magnetic field outside the static magnetic field unit, and a radiofrequency unit (14) for generating a generally cylindrically symmetric radiofrequency field outside the radiofrequency unit. The radiofrequency field is perpendicular to the static magnetic field. A spatial inhomogeneity of the magnetic field substantially matches a spatial inhomogeneity of the radiofrequency field.Type: GrantFiled: August 27, 2008Date of Patent: June 11, 2013Assignee: Technion Research & Development Foundation LimitedInventors: Aharon Blank, Itai Katz
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Publication number: 20130093424Abstract: A resonator system for electron spin resonance (ESR) is disclosed. The resonator system comprises: a generally planar resonator layer defining an open-loop gapped by a non-conductive gap in the layer, and a microwave feed, positioned configured for transmitting microwave to the resonator layer such as to concentrate, with a quality factor of at least 100, a magnetic field within an effective volume of less than 1 nL above the layer.Type: ApplicationFiled: October 18, 2011Publication date: April 18, 2013Inventors: Aharon BLANK, Ygal TWIG
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Publication number: 20120025828Abstract: A device of estimating a dose of ionizing radiation absorbed in an intra bone volume. The device comprises a static magnetic field source adapted to generate a substantially static magnetic field in a probing space having a volume of less than 2 cubic millimeter (mm3), the probing space being placed in front of a distal end of static magnetic field source, a micro resonator mounted in adjacent to the distal end, and at least one transmission line which feeds the resonator so as to generate an microwave magnetic field at the probing space and to transmit a signal returned from said microwave magnetic field and indicative of radiation induced paramagnetic defects in said probing space so as to allow a spectrometer to compute a dose of ionizing radiation absorbed in a portion of a bone placed in the probing space according to an analysis of the signal. The static magnetic field source being sized and shaped to maneuver the probing space to overlap with an intra bone volume of the bone.Type: ApplicationFiled: April 15, 2010Publication date: February 2, 2012Applicant: Technion Research & Development Foundation Ltd.Inventors: Aharon Blank, Ygal Twig
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Patent number: 8067937Abstract: ESR imaging probe, system, and method are described. The probe is an ex-situ probe, the system comprises the probe and configured for operating the probe, and the method comprises detecting ESR from outside a resonator of the probe. An exemplary embodiment of a probe according to the invention comprises a cooled dielectric resonator, and one sided gradient coils. An exemplary embodiment of the system comprises source current that is configured to supply to the gradient coils currents of up to 100 A in pulses shorter than 1 ?sec.Type: GrantFiled: June 14, 2007Date of Patent: November 29, 2011Assignee: Technion Research & Development Foundation Ltd.Inventors: Aharon Blank, Lazar Shtirberg
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Publication number: 20100308820Abstract: A device for ex situ magnetic resonance analysis is disclosed. The device comprises a static magnetic field unit (12) for generating a generally cylindrically symmetric static magnetic field outside the static magnetic field unit, and a radiofrequency unit (14) for generating a generally cylindrically symmetric radiofrequency field outside the radiofrequency unit. The radiofrequency field is perpendicular to the static magnetic field. A spatial inhomogeneity of the magnetic field substantially matches a spatial inhomogeneity of the radiofrequency field.Type: ApplicationFiled: August 27, 2008Publication date: December 9, 2010Inventors: Aharon Blank, Itai Katz
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Publication number: 20100001728Abstract: ESR imaging probe, system, and method are described. The probe is an ex-situ probe, the system comprises the probe and configured for operating the probe, and the method comprises detecting ESR from outside a resonator of the probe. An exemplary embodiment of a probe according to the invention comprises a cooled dielectric resonator, and one sided gradient coils. An exemplary embodiment of the system comprises source current that is configured to supply to the gradient coils currents of up to 100 A in pulses shorter than 1 ?sec.Type: ApplicationFiled: June 14, 2007Publication date: January 7, 2010Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Aharon Blank, Lazar Shtirberg
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Publication number: 20080234569Abstract: A rectal probe adapted for ultrasound and magnetic resonance imaging of the prostate, comprising: a) an ultrasound imaging probe; b) an MRI probe comprising a first magnetic field source for creating a static magnetic field in an MRI imaging region outside the rectal probe, a second magnetic field source for creating a time-varying magnetic field which excites nuclei in the MRI imaging region, and a receiver for receiving NMR signals from the excited nuclei and generating MRI imaging data indicative thereof; and c) a link joining the ultrasound probe and the MRI probe.Type: ApplicationFiled: January 20, 2005Publication date: September 25, 2008Applicant: Topspin Medical (Israel) Ltd.Inventors: Gil Tidhar, Aharon Blank
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Patent number: 7403008Abstract: ESR microscope systems and methods for examining specimens using both continuous wave and pulsed modes in the 9 to 60 GHz range. The ESR microscope uses an image probe comprising gradient coils in addition to conventional modulation coils (in continuous wave mode) or magnetic field bias coils (in pulse mode), and a resonator constructed from high permittivity material. The systems and methods also involves the use of sample containers that permit the precise placement of samples in relation to the image probe. The microscope uses a microstrip or thin coaxial or dielectric antenna to obtain a high coupling coefficient to the specimen being imaged. The microscope systems provide resolution at the single micron level, and permit the observation of images comprising tens to hundreds of pixels for each of two or three dimensions in a few minutes. Novel stable radicals used as the imaging media are also described.Type: GrantFiled: August 2, 2005Date of Patent: July 22, 2008Assignee: Cornell Research Foundation, Inc.Inventors: Aharon Blank, Curt R. Dunnam, Peter P. Borbat, Jack H. Freed
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Publication number: 20060084861Abstract: A probe, with a longitudinal axis, for use in an NMR system, the probe comprising: (a) a plurality of static magnetic field sources which create a static magnetic field that is non-axisymmetric about the longitudinal axis, in a region outside the probe; and (b) at least one antenna, compromising one or more antennas together capable of creating a time-varying magnetic field which is capable of exciting nuclei in a sub-region of the region, and capable of receiving NMR signals from said excited nuclei and generating NMR electrical signals therefrom; wherein the plurality of magnetic field sources comprise adjacent static magnetic field sources that are magnetized in directions that differ by more than 10 degrees and less than 170 degrees.Type: ApplicationFiled: October 18, 2004Publication date: April 20, 2006Applicant: TopSpin Medical (Isreal) Ltd.Inventors: Aharon Blank, Gadi Lewkonya, Yuval Zur, Hanna Friedman, Gil Tidhar