Patents by Inventor Ahmad Khodabocus

Ahmad Khodabocus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 2,3-disubstituted indoles
    Patent number: 7851625
    Abstract: Disclosed are processes for making 2, 3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: December 14, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ahmad Khodabocus, Zhi-Hui Lu, Chris Hugh Senanayake, Hanxun Wei, Yongda Zhang
  • Process for preparing 2,3-disubstituted indoles
    Patent number: 7642352
    Abstract: Disclosed are processes for making 2,3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: January 5, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ahmad Khodabocus, Zhi-Hui Lu, Chris Hugh Senanayake, Hanxun Wei, Yongda Zhang
  • PROCESS FOR PREPARING 2,3-DISUBSTITUTED INDOLES
    Publication number: 20090264655
    Abstract: Disclosed are processes for making 2, 3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
    Type: Application
    Filed: June 19, 2009
    Publication date: October 22, 2009
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Ahmad KHODABOCUS, Zhi-Hui Lu, Chris Hugh Senanayake, Hanxun Wei, Yongda Zhang
  • Process for cross coupling indoles
    Patent number: 7332614
    Abstract: The present invention provides a process for making a compound of general formula I: wherein: R=H or C1-8alkyl X=C3-C8cycloalkyl, C3-C8aryl or C3-C8alkyl; Y=heteroaryl or aryl; Z=H, HO2C—, C1-8alkyl O2C—, C1-6alkyl HNC(O)—, and as described herein.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: February 19, 2008
    Assignee: Boehringer Ingelheim International, GmbH
    Inventors: Ahmad Khodabocus, Guisheng Li, Zhi-Hui Lu, Frank Roschangar, Chris Hugh Senanayake, Ming Shen
  • Process for making 5,11-Dihydro-11-ethyl-5-methyl-8{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2?,3?-e][1,4]diazepin-6-one
    Patent number: 7282583
    Abstract: An improved process for making 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2?,3?-e][1,4]diazepin-6-one.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: October 16, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Saeed Ahmad, Robert Frederick Boswell, Jr., Jack Delbert Brown, Cary Mark Davis, Kai Oliver Donsbach, Bernard Franklin Gupton, Christopher Peter Johnson, III, Ahmad Khodabocus, Vithalanand R. Kulkarni, Young S. Lo
  • Process for making 5,11-Dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
    Publication number: 20070129542
    Abstract: An improved process for making 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2?,3?-e][1,4]diazepin-6-one.
    Type: Application
    Filed: November 16, 2006
    Publication date: June 7, 2007
    Inventors: Saeed Ahmad, Robert Boswell, Jack Brown, Cary Davis, Kai Donsbach, Bernard Gupton, Christopher Johnson, Ahmad Khodabocus, Vithalanand Kulkarni, Young Lo
  • Process for preparing 2, 3-disubstituted indoles
    Publication number: 20060183752
    Abstract: Disclosed are processes for making 2,3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
    Type: Application
    Filed: February 10, 2006
    Publication date: August 17, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Ahmad Khodabocus, Zhi-Hui Lu, Chris Senanayake, Hanxun Wei, Yongda Zhang
  • Process for cross coupling indoles
    Publication number: 20050234242
    Abstract: The present invention provides a process for making a compound of general formula I: wherein: R=H or C1-8alkyl X=C3-C8cycloalkyl, C3-C8aryl or C3-C8alkyl; Y=heteroaryl or aryl; Z=H, HO2C—, C1-8alkyl O2C—, C1-6alkyl HNC(O)—, and as described herein.
    Type: Application
    Filed: March 7, 2005
    Publication date: October 20, 2005
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Ahmad Khodabocus, Guisheng Li, Zhi-Hui Lu, Frank Roschangar, Chris Senanayake, Ming Shen