Patents by Inventor Ahmad R. Safa

Ahmad R. Safa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vinca alkaloid photoactive analogs and their uses
    Patent number: 4765972
    Abstract: Pharmacologically active, radioactive, and photoactive vinblastine analogs are provided which can be used to bind covalently to cellular polypeptides which have high affinity for Vinca alkaloids. The compounds are N-(p-azido[3,4-.sup.3 H]benzoyl)-N'beta-aminoethylvindesine and N-p-azido-[3-.sup.125 I]-salicyl-N'-beta-aminoethylvindesine. The compounds can be used to identify cellular Vinca alkaloid receptors which may be involved in antineoplastic, cytotoxic and drug resistant mechanisms of actions. In addition to specific interaction with tubulin, these compounds specifically bind to a 150-180 kDa surface membrane glycoprotein which is overexpressed in multidrug resistant cells.
    Type: Grant
    Filed: April 3, 1986
    Date of Patent: August 23, 1988
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ahmad R. Safa, Ronald L. Felsted