Abstract: Chatbot conversation management includes a generic model associated with a first property associated with a chatbot manager. The generic model is generated based on machine learning. A refined model that is associated with the first property is generated based on the generic model and a first plurality of phrases. A first conversation is held between a chatbot and an end user. A determination is made regarding storage of a value of a first property for the end user that is obtained via the chatbot. The refined model is used to dynamically ask questions to the end user to determine a value of the first property for the end user.

Abstract: The present invention relates to the use of at least one protease for the manufacture of a medicament for the treatment and/or prevention of ocular diseases related to neoangiogenesis selected from the group consisting of age related macular degeneration (AMD), choroidal neovascularization, Hippel-Lindau Disease, iris neovascularization, ischemic proliferative retinopathy, neovascularization of the Cornea, and proliferative sickle cell retinopathy, wherein the at least one protease is selected from the group consisting of plant, non-mammalian animal and microbial proteases.

Abstract: The present invention relates to the use of at least one protease for the manufacture of a medicament for the treatment and/or prevention of ocular diseases related to neoangiogenesis selected from the group consisting of age related macular degeneration (AMD), choroidal neovascularisation, Hippel-Lindau Disease, iris neovascularisation, ischemic proliferative retinopathy, neovascularisation of the Cornea, and proliferative sickle cell retinopathy, wherein the at least one protease is selected from the group consisting of plant, non-mammalian animal and microbial proteases.