Patents by Inventor Ahmed Aqeel

Ahmed Aqeel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE
    Publication number: 20130012466
    Abstract: Colchicine neoglycosides, method for their synthesis and methods for their use are disclosed. The invention provides analogs of colchicine glycosylated to include a sugar moiety on a colchicine scaffold that is generally unglycosylated in nature. The colchicine neoglycosides disclosed herein are shown to have cytotoxic effects equivalent to at least the known cytotoxins paclitaxel and doxorubicin. Further, the neoglycosides disclosed according to the invention have physiologic effects not previously recognized in the alkaloid family that includes colchicine but recognized in other cytotoxic drug families such as the taxanes which act by stabilizing tubulin formation.
    Type: Application
    Filed: July 9, 2012
    Publication date: January 10, 2013
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Jon S. Thorson, Ahmed Aqeel
  • Colchicine neoglycosides and methods for their synthesis and use
    Patent number: 8232254
    Abstract: Colchicine neoglycosides, method for their synthesis and methods for their use are disclosed. The invention provides analogs of colchicine glycosylated to include a sugar moiety on a colchicine scaffold that is generally unglycosylated in nature. The colchicine neoglycosides disclosed herein are shown to have cytotoxic effects equivalent to at least the known cytotoxins paclitaxel and doxorubicin. Further, the neoglycosides disclosed according to the invention have physiologic effects not previously recognized in the alkaloid family that includes colchicine but recognized in other cytotoxic drug families such as the taxanes which act by stabilizing tubulin formation.
    Type: Grant
    Filed: October 8, 2007
    Date of Patent: July 31, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jon S. Thorson, Ahmed Aqeel
  • COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE
    Publication number: 20080171787
    Abstract: Colchicine neoglycosides, method for their synthesis and methods for their use are disclosed. The invention provides analogs of colchicine glycosylated to include a sugar moiety on a colchicine scaffold that is generally unglycosylated in nature. The colchicine neoglycosides disclosed herein are shown to have cytotoxic effects equivalent to at least the known cytotoxins paclitaxel and doxorubicin. Further, the neoglycosides disclosed according to the invention have physiologic effects not previously recognized in the alkaloid family that includes colchicine but recognized in other cytotoxic drug families such as the taxanes which act by stabilizing tubulin formation.
    Type: Application
    Filed: October 8, 2007
    Publication date: July 17, 2008
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Jon S. Thorson, Ahmed Aqeel