Abstract: Provided herein are methods for treating acute myeloid leukemia (AML) in a patient with cytopenia when on a combination therapy of venetoclax and azacitidine. Also provided herein are methods of managing a cytopenia in such patient.

Abstract: A computing system implementing a physical verification tool can identify edges of a geometric pattern located within a search area surrounding a point of interest in a semiconductor layout design, characterize the edges of the geometric pattern based on locations of center points of the edges from the point of interest within the search area, and generate geometrical feature vectors for the point of interest in the semiconductor layout design based on the characterization of the edges of the geometric pattern. The computing system can reconstruct the semiconductor layout design corresponding to the search area surrounding the point of interest using the geometrical feature vectors for the point of interest in the semiconductor layout design.

Abstract: The invention described herein relates to dosing methods for treating relapsed and refractory multiple myeloma (RRMM) in a human subject comprising administering to the subject venetoclax in combination with daratumumab and dexamethasone.

Abstract: A computing system implementing a physical verification tool can determine principal feature components describing geometric patterns around points of interest in a semiconductor layout design. The principal feature components include topological features indicating whether structures are present around the points of interest, and include dimensional features corresponding to measurements associated with the structures present around the points of interest. The physical verification tool can generate a topological signature for each of the points of interest based on the topological features, and cluster the points of interest into different subsets based on the topological signature.

Abstract: Provided herein are methods for treating acute myeloid leukemia (AML) in a patient with cytopenia when on a combination therapy of venetoclax and azacitidine. Also provided herein are methods of managing a cytopenia in such patient.

Abstract: Provided herein are methods for treating acute myeloid leukemia (AML) in a patient with cytopenia when on a combination therapy of venetoclax and azacitidine. Also provided herein are methods of managing a cytopenia in such patient.

Abstract: Systems and methods for analyzing a semiconductor layout design around a point of interest (POI) are disclosed. Semiconductor layout designs are a representation of an integrated circuit in terms of planar geometric shapes which make up the components of the integrated circuit, and are used to manufacture the integrated circuit. The layout design may be analyzed using one or more POI-based approaches to determine whether to modify the layout design. In one POI-based approach, set of kernels, tailored to the downstream application, are convolved with a representation of the layout design about or around the POI in order to generate a signature associated with the POI. In turn, the signatures may be analyzed based on the downstream application. Another POI-based approach consists of analyzing geometrical parameters associated with the POI, which may be used during a design stage to identify and modify problem areas in the layout design.

Abstract: System and methods for an edge-based camera are disclosed. Semiconductor layout designs are a representation of an integrated circuit that are used to manufacture the integrated circuit. Parts of the layout design, such as points of Interest (POIs), may be subject to analysis with regard to a downstream application, such as hotspot detection. Unlike pixel-based characterizations, POIs are characterized using topological features indicative of quantized values and dimensional features indicative of analog values. For example, an edge may be characterized using a set of relations, which characterizes corners and polygons (including the polygon on which the POI resides and external polygons). In turn, the set of relations may be used to define image representations, including images in different directions relative to the POI (including cardinal and ordinal image). In this way, the topological/dimensional characterization of the POI may be used to analyze the POI in the layout design.

Abstract: System and methods for an edge-based camera are disclosed. Semiconductor layout designs are a representation of an integrated circuit that are used to manufacture the integrated circuit. Parts of the layout design, such as points of Interest (POIs), may be subject to analysis with regard to a downstream application, such as hotspot detection. Unlike pixel-based characterizations, POIs are characterized using topological features indicative of quantized values and dimensional features indicative of analog values. For example, an edge may be characterized using a set of relations, which characterizes corners and polygons (including the polygon on which the POI resides and external polygons). In turn, the set of relations may be used to define image representations, including images in different directions relative to the POI (including cardinal and ordinal image). In this way, the topological/dimensional characterization of the POI may be used to analyze the POI in the layout design.

Abstract: A subterranean zone penetrated by a wellbore is hydraulically fractured. A well tool assembly is positioned within a casing installed in the wellbore. The well tool assembly includes a perforation tool and a resettable packer. The casing is perforated, such that fluid can be conducted from inside the casing to the subterranean zone through the perforations. The well tool assembly is positioned at a location within the casing that is downhole of the perforations. A portion of the casing that is downhole of the perforations is sealed with the resettable packer. A fracturing fluid is pulsed into the subterranean zone via the perforations by alternating between a first flow rate and a second flow rate. The second flow rate is in a range of from about 10% to about 40% of the first flow rate. The fracturing fluid is free of proppant.

Abstract: This application discloses an electronic control unit coupled to a bus in a vehicle communication network. The electronic control unit includes a processing system configured to generate an instruction including an identifier of a type of signal exchanged through a vehicle communication network and including a command associated with exchange of a signal value corresponding to the type of the signal. The electronic control unit includes a communication circuitry configured to identify, based on the type of the signal in the instruction, a packet having a section allocated for the signal value corresponding to the type of the signal. The communication circuitry also can perform packet operations on the section of the packet allocated for the signal value based, at least in part, on the command included in the instruction. The packet operations can include packing the signal value into the packet or extracting the signal value from the packet.

Abstract: This application discloses an electronic control unit coupled to a bus in a vehicle communication network. The electronic control unit includes a processing system configured to generate an instruction including an identifier of a type of signal exchanged through a vehicle communication network and including a command associated with exchange of a signal value corresponding to the type of the signal. The electronic control unit includes a communication circuitry configured to identify, based on the type of the signal in the instruction, a packet having a section allocated for the signal value corresponding to the type of the signal. The communication circuitry also can perform packet operations on the section of the packet allocated for the signal value based, at least in part, on the command included in the instruction. The packet operations can include packing the signal value into the packet or extracting the signal value from the packet.

Abstract: Systems and methods for molecular fingerprinting to identify Inbreeding and Outbreeding Depression Factors (IODFs) in an animal are described. In one aspect, the systems and methods receive inputs such as information pertaining to a set of loci, allele quantity and size, genotype, and/or so on. The systems and methods calculate, based on at least a subset of inputs and a set of microsatellite markers, an IODF. The systems and methods evaluate the calculated IODF to determine if the animal is a suitable/good candidate for a breeding program.

Abstract: A method for producing oil from an underground formation comprising providing a first well in one or more formations, the first well comprising a plurality of sections along a length of the well; providing a second well in the formation; injecting an enhanced oil recovery formulation into at least a first section and a second section of the first well and into the formation; flowing the formulation and/or oil towards the second well in one or more formations; producing the formulation and/or oil from the second well; and then modifying the injecting into the second section, while continuing the injecting into the first section.