Patents by Inventor Ahmed Hussein BADREN

Ahmed Hussein BADREN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170233708
    Abstract: Some aspects of this disclosure provide methods for phage-assisted continuous evolution (PACE) of proteases. Some aspects of this invention provide methods for evaluating and selecting protease inhibitors based on the likelihood of the emergence of resistant proteases as determined by the protease PACE methods provided herein. Some aspects of this disclosure provide strategies, methods, and reagents for protease PACE, including fusion proteins for translating a desired protease activity into a selective advantage for phage particles encoding a protease exhibiting such an activity and improved mutagenesis-promoting expression constructs. Evolved proteases that recognize target cleavage sites which differ from their canonical cleavage site are also provided herein.
    Type: Application
    Filed: October 22, 2015
    Publication date: August 17, 2017
    Applicant: President and Fellows of Harvard College
    Inventors: David R. LIU, Bryan DICKINSON, Michael S. PACKER, Ahmed Hussein BADREN