Abstract: The claimed subject matter relates to an architecture that can construct a map for summarizing analyses with respect to data included in a database. In addition, the architecture can display the map in a special canvas area. Generally, the map is a hub-and-spoke-style map in which a hub is associated with an entity (e.g., a related set of records) included in a database. Likewise, the spokes are typically representative of operations (e.g., filter, join, transform) that act upon the hub/entity from which it extends. The map can aid with open-ended analysis on complex databases by recording and ordering competing hypotheses and can also further collaborative efforts with respect to analysis.

Abstract: The present invention provides a compound of formula 5, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of formula 5a-t.

Abstract: The present disclosure provides a compound of general formula A useful as potential anti-tubercular agents.

Abstract: The present invention provides a compound of general formula 5, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formula (5): wherein n=3, 4, 5, 6, 8 and wherein R1 and R2 is selected from the group consisting of R1?H, R2?H or R1?CH3O, R2=CH3O or R1?CH3O and R2?C2H5O.

Abstract: A multi-ply fibrous structure product having two or more plies of fibrous structure where at least one of the plies has a plurality of domes formed during the papermaking process and there are from about 10 to about 1000 domes per square inch of the product. At least one of the plies of the multi-ply fibrous structure has a plurality of embossments thereon with a total embossment area of from about 3% to about 15%. The embossments may be arranged such that they define non-geometric foreground patterns of unembossed cells.

Abstract: The present invention provides a compound of general formula (9), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4][benzodiazepine g hybrids of general formula (9).

Abstract: A method for conducting a virtual training session with first and second training objectives having first and second validation paths, respectively. The method steps include configuring a virtual machine manipulated by a student to complete the first training objective, configuring a smart agent to execute on the virtual machine including a validator specified by the first validation path, generating a result by performing a first validation check of the virtual training session by at least the validator of the smart agent to identify an event of the virtual machine, identifying, using the smart agent, completion of the first training objective based on the result, and advancing the virtual training session from the first training objective to the second training objective in response to identifying completion of the first training objective.

Abstract: The present invention relates to chalcone linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for the preparation there of. More particularly it relates to 7-Methoxy-8-{n[4-1-(2 or 4-substituted phenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one]alkyl}-oxy}-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one and 7-Methoxy-8-{n[-3-(4-hydroxy-3-methoxyphenyl)-1-(2,4-alkyl-3-quinolyl)-2-propen-1-one]alkyl}-oxy-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one with aliphatic chain length variations useful as anticancer (antitumour) agent. The general structural formula of these chalcone linked pyrrolo[2,1-c][1,4]benzodiazepines hybrids is given below.

Abstract: The present invention provides a compounds of general formula IXa-d, useful as potential antitumour agents and pharmaceutical composition comprising these compounds exhibits binding affinity with calf thymus (CT) DNA at a molar ratio of 1:5 in aqueous sodium phosphate buffer at pH of 7.00. The present invention further provides a process for the preparation of C2-Fluoro substituted piperazine linked pyrrolo[2,1c][1-4], benzodiazepine of formula (IX).

Abstract: The present invention provides a compounds of general formula (8), (11) and (14), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo [2,1-c][1,4]benzodiazepine hybrids of general formula (8), (11) and (14).

Abstract: Methods for manufacturing micromachined devices and the devices obtained are disclosed. In one embodiment, the method comprises providing a structural layer comprising an amorphous semiconductor material, forming a shielding layer on a first portion of the structural layer and leaving exposed a second portion of the structural layer, and annealing the second portion using a first fluence. The method further comprises removing the shielding layer, and annealing the first portion and the second portion using a second fluence that is less than half the first fluence. In an embodiment, the device comprises a substrate layer, an underlying layer formed on the substrate layer, and a sacrificial layer formed on only a portion of the underlying layer. The device further comprises a structural layer that is in contact with the underlying layer and comprises a first region annealed using a first fluence and a second region annealed using a second fluence.

Abstract: The present invention provides a compound of general formula 5, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formula (5): wherein n=3, 4, 5, 6, 8 and wherein R1 and R2 is selected from the group consisting of R1?H, R2?H or R1?CH3O, R2=CH3O or R1?CH3O and R2?C2H5O.

Abstract: MEMS mass-spring-damper systems (including MEMS gyroscopes and accelerometers) using an out-of-plane (or vertical) suspension scheme, wherein the suspensions are normal to the proof mass, are disclosed. Such out-of-plane suspension scheme helps such MEMS mass-spring-damper systems achieve inertial grade performance. Methods of fabricating out-of-plane suspensions in MEMS mass-spring-damper systems (including MEMS gyroscopes and accelerometers) are also disclosed.

Abstract: An system and method for exploring geophysical formations at great depths below the surface of the earth. In order to explore the formation, nanorobots with a size less than 500 nanometers are inserted into the formation. The nanorobots propel through the formation, analyzing fluids and conditions as each moves through the formation. The nanorobots can communicate with a machine on the surface via a series of receivers and transmitters located in the wellbore. The machine on the surface is able to combine and analyze the data from the nanorobots to create a three dimensional map of the formation. The map shows the locations of pathways through the formation, pockets of hydrocarbons within the formation, and the boundaries of the formation.

Abstract: The present invention provides a chemoenzymatic process for the preparation of (R)-GABOB and (R)-carnitine employing lipase-mediated resolution of 3-hydroxy-4-tosyloxybutanenitrile as the key step. The drawing accompanying this specification represents the preparation of racemic 3-hydroxy-4-tosyloxybutanenitrile, its lipase-mediated kinetic resolution and its successful application in the preparation of (R)-GABOB and (R)-carnitine.

Abstract: Disclosed herein are benzophenone hybrids with potent anticancer activities and processes for creation of the same.

Abstract: The present invention provides a compound of general formula (9), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4][benzodiazepine g hybrids of general formula (9).

Abstract: The present invention provides novel anthranilic acid derivative useful as potential anticancer agent. More particularly, the present invention relates novel anthranilic acid derivative of general formula (8), R?=alkyl-2-methoxyphenyl piperazine (or) benzyl, R=2 methoxy phenyl, piperazine, 2-pyridyl piperazine, 2-pyrimidyl piperazine, 4-quinazolinyl piperazine, 9H-9-fluorenylamine, 4-{(2{amino-5-(methoxy)-4-[(phenylmethyl)oxy]phenyl}carbonyl)hexahydro-1-pyrazinyl], and [(4[2 amino-4-(benzyloxy)-5-methoxybenzoyl]aminophenyl)sulfonyl]-4-benzamine; X?H (or) pyrazine-2-carbonyl. The present invention also provides a process for the preparation of novel anthranilic acid derivative of general formula (8), which is useful as potential anticancer agent.

Abstract: A system and method for donations using online interactive games with players using social networks. Users play games wherein winning results in others donating to their selected recipient, such as a cause, charity, school, etc. A database maintains user information, recipient information, and tracks donation credits. Users play games, donate to recipients, and have players donate to their selected recipients. The system and method can automatically match users as teammates, competitors, and tournament members. The system and method facilitate game play, collection of funds, and payment of collected funds to selected recipients. The funds benefit recipients, and new supporters are identified to the recipients.

Abstract: The claimed subject matter relates to an architecture that can construct a map for summarizing analyses with respect to data included in a database. In addition, the architecture can display the map in a special canvas area. Generally, the map is a hub-and-spoke-style map in which a hub is associated with an entity (e.g., a related set of records) included in a database. Likewise, the spokes are typically representative of operations (e.g., filter, join, transform) that act upon the hub/entity from which it extends. The map can aid with open-ended analysis on complex databases by recording and ordering competing hypotheses and can also further collaborative efforts with respect to analysis.