Abstract: The present invention relates to a reaction unit (10) configured to receive a reaction solution or culture media and configured to be placed inside a thermocycler, said reaction unit (10) comprising an elongated hollow body (12) extending along a flowing axis X, the hollow body (12) thus displaying a first opening (14) at its first extremity (16) and a second opening (18) at its second extremity (20). The walls of the hollow body (12) are at least partially made of a thermally conductive material. The reaction unit (10) further comprises at least one filter element (22) extending inside the hollow body (12), the filter element (22) being sealingly secured to the walls of the hollow body (12) over its complete circumference, leading any fluid flowing from the first opening (14) to the second opening (18) to cross the at least one filter element (22).

Abstract: Thermocycling multistep reaction device comprising a reaction plate (12) comprising at least one well (14) and at least one internal fluid circulation channel arranged around the at least one well (14), an evacuation system (16), a first circuit being aimed, when activated, at driving a first heat transfer fluid through the at least one internal fluid circulation channel, a second circuit being aimed, when activated, at driving a second heat transfer fluid through the at least one internal fluid circulation channel, and a control unit. The temperature inside the at least one well (14) is regulated and controlled by means of the control unit which selectively activates the circuits, each well (14) is connected to the evacuation system (16) by means of at least one filter membrane.

Abstract: Thermocycling multistep reactions device (10) comprising: a reaction plate (12) comprising at least one well (14), at least one internal thermoregulating fluid circulation circuit configured to be arranged in direct contact with the at least one well (14), an evacuation system, a control unit configured to manage the temperature of the internal thermoregulating fluid circuit. The temperature inside the at least one well (14) is regulated and controlled by means of the control unit. Each well (14) is connected to the evacuation system by means of at least one filter membrane, and the thermoregulating fluid circuit is made of a heat conducting material while the reaction plate is made (12) of a polymerous material.

Abstract: Compositions for treating a wellbore include an exothermic additive capable of initiating an exothermic event following contact with a carrier fluid. The exothermic additive can have a coating that delays the exothermic event after contact with the carrier fluid. Methods disclosed herein include emplacing a fluid loss treatment composition in an interval of a wellbore, the fluid loss treatment including: a metallic fluid loss additive; an exothermic additive; and a carrier fluid; and reacting the exothermic additive to initiate an increase in temperature in the interval of the wellbore above a melting point of the metallic fluid loss additive; and converting the metallic fluid loss additive to a molten fluid loss additive; and treating the interval of the wellbore with the molten fluid loss additive.

Abstract: An underpinning device for support a structure is provided. The underpinning device is anchored within the ground using a grout or cement. The underpinning device comprises a rod having a proximal rod end and a distal rod end. A first interacting element is coupled to the proximal rod end and is encased in the slab of a building. A second interacting element is coupled to the distal rod end and include a removable tip. Upon insertion into the ground, the tip dissociates from the second interacting element creating an opening at the distal rod end. A fluid, such as grout and/or cement is injected into the pipe and extruded through channels within the rod. The fluid is then allowed to cure thereby anchoring the underpinning device within the ground.

Abstract: The invention relates to the field of nucleic acid synthesis or sequencing, more specifically to methods for ab-initio synthesis of nucleic acids, comprising contacting a nucleotide with a free 3?-hydroxyl group, with at least one nucleoside triphosphate, or a combination of nucleoside triphosphates, in the presence of an archaeal DNA primase or a functionally active fragment and/or variant thereof, thereby covalently binding said nucleoside triphosphate to the free 3?-hydroxyl group of the nucleotide. It also relates to isolated functionally active fragments of archaeal DNA primases which are capable of both ab-initio single-stranded nucleic acid synthesis activity and template-independent terminal nucleotidyl transferase activity.

Abstract: The invention relates to methods for template-independent synthesis of nucleic acids, comprising iteratively contacting an initiator sequence comprising a 3?-end nucleotide with a free 3?-hydroxyl group, with at least one nucleoside triphosphate, or a combination of nucleoside triphosphates, in the presence of an archaeal DNA primase or a functionally active fragment and/or variant thereof, thereby covalently binding said nucleoside triphosphate to the free 3-hydroxyl group of the 3-end nucleotide. It also relates to isolated functionally active fragments of archaeal DNA primases which are capable of template-independent terminal nucleotidyl transferase activity but are devoid of a template-independent primase activity.

Abstract: A cannabinoid-HA conjugate, according to the present invention, has a polysaccharide backbone of hyaluronic acid or an analog or derivative thereof, having a cannabinoid attached by way of a spacer to one or more derivatization sites of the polysaccharide backbone selected from the group consisting of: a primary hydroxyl group, a secondary hydroxyl group, a carboxyl group, and an acetamido group. One or more of the cannabinoids may be used as a cross-linking agent to covalently cross-link the polysaccharide backbone to control biodegradation and duration of action.

Abstract: The present invention relates to variant of Family A polymerases able to synthesize a nucleic acid fragment without template and to incorporate a reversible modified terminator nucleotide during the nucleic acid fragment synthesis. The present invention further relates to uses thereof for enzymatic synthesis of nucleic acid molecules.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for agent trajectory prediction using context-sensitive fusion.

Abstract: The present invention relates to variant of Family A polymerases able to synthesize a nucleic acid fragment without template and to incorporate a reversible modified terminator nucleotide during the nucleic acid fragment synthesis. The present invention further relates to uses thereof for enzymatic synthesis of nucleic acid molecules.

Abstract: The present invention relates to variant of Family A polymerases able to synthesize a nucleic acid fragment without template and to incorporate a reversible modified terminator nucleotide during the nucleic acid fragment synthesis. The present invention further relates to uses thereof for enzymatic synthesis of nucleic acid molecules.

Abstract: A method for proactively detecting shared libraries suspected of association with malware includes the steps of determining one or more shared libraries loaded on an electronic device, determining that one or more of the shared libraries include suspicious shared libraries by determining that the shared library is associated with indications that the shared library may have been maliciously injected, loaded, and/or operating on the electronic device, and identifying the suspicious shared libraries to a reputation server.

Abstract: Systems and methods of performing rate limiting traffic shaping with a time-indexed data structure in a network device are provided. A network interface driver of the network device can received packets at the packet layer of a network host from a plurality of applications. The network interface driver can prevent one of the applications from sending additional packets for transmission until the application received a transmission completion notification indicating a packet previously forwarded to the packet layer of the network host has been transmitted. The network interface driver can process the received packets to determine a transmission time for each packet based on at least on rate limit policy. The network interface driver can store an identifier associated with the respective packet in a time-indexed data structure at a position associated with the transmission time determined for the packet.

Abstract: Systems and methods of performing rate limiting with a time-indexed data structure in a network device are provided. A transport protocol module of the network device can receive data packets from a remote computing device. The transport protocol module can generate a packet acknowledgement message which is received by the network interface driver. The network interface driver can process the received packet acknowledgement message to determine a transmission time for the packet acknowledgement message based on at least on rate limit policy. The network interface driver can store an identifier associated with the packet acknowledgement message in a time-indexed data structure. The network interface driver can determine that a time indexed in the time-indexed data structure has been reached and in response transmit a packet acknowledgement message associated with the identifier stored in the time-indexed data structure at a position associated with the reached time.

Abstract: Systems and methods of performing rate limiting traffic shaping with a time-indexed data structure in a network device are provided. A network interface driver of the network device can received packets at the packet layer of a network host from a plurality of applications. The network interface driver can prevent one of the applications from sending additional packets for transmission until the application received a transmission completion notification indicating a packet previously forwarded to the packet layer of the network host has been transmitted. The network interface driver can process the received packets to determine a transmission time for each packet based on at least on rate limit policy. The network interface driver can store an identifier associated with the respective packet in a time-indexed data structure at a position associated with the transmission time determined for the packet.

Abstract: A method for proactively detecting shared libraries suspected of association with malware includes the steps of determining one or more shared libraries loaded on an electronic device, determining that one or more of the shared libraries include suspicious shared libraries by determining that the shared library is associated with indications that the shared library may have been maliciously injected, loaded, and/or operating on the electronic device, and identifying the suspicious shared libraries to a reputation server.

Abstract: Named entity recognition is described, for example, to detect an instance of a named entity in a web page and classify the named entity as being an organization or other predefined class. In various examples, named entity recognition results are used to augment text from which the named entity was recognized; the augmentation may comprise information retrieval results about the named entity mention. In various embodiments, labeled training sentences in many different languages and for many different classes, are obtained to train machine learning components of a multi-lingual, multi-class, named entity recognition system. In examples, labeled training sentences are obtained from at least two sources, a first source using a multi-lingual or monolingual corpus of inter-linked documents and a second source using machine translation training data. In examples, labeled training sentences from the two sources are selectively sampled for training the named entity recognition system.

Abstract: A computer-implemented method of conducting online meetings includes gathering sensed environment information from a set of intelligent sensor devices in physical user environments, along with meeting information describing online meetings in which the users participate while located in the respective environments. The sensed environment information and meeting information are stored in an event database, intelligent environment-control devices in the physical user environments are configured for subsequent online meetings. The configuring includes operating a stateful behavioral engine using the sensed environment information and meeting information from the event database to identify patterns of user behavior and to configure the intelligent environment-control devices according to the identified patterns of user behavior.

Abstract: A system, method and computer program product are provided for sending, to a central system, information associated with unwanted activity. In use, information associated with unwanted activity is identified utilizing a plurality of different types of security systems. Further, the information is sent to a central system.