Abstract: A cannabinoid-HA conjugate, according to the present invention, has a polysaccharide backbone of hyaluronic acid or an analog or derivative thereof, having a cannabinoid attached by way of a spacer to one or more derivatization sites of the polysaccharide backbone selected from the group consisting of: a primary hydroxyl group, a secondary hydroxyl group, a carboxyl group, and an acetamido group. One or more of the cannabinoids may be used as a cross-linking agent to covalently cross-link the polysaccharide backbone to control biodegradation and duration of action.