Patents by Inventor Ahmi Ben-Yehudah

Ahmi Ben-Yehudah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC PROTEINS WITH CELL-TARGETING SPECIFICITY AND APOPTOSIS-INDUCING ACTIVITIES
    Publication number: 20090317358
    Abstract: The present invention relates to chimeric proteins with cell-targeting specificity and apoptosis-inducing activities. In particular, the invention is illustrated by a recombinant chimeric protein between human interleukin-2 (IL2) and Bax. The chimeric protein specifically targets IL2 receptor (IL2R)-expressing cells and induces cell-specific apoptosis.
    Type: Application
    Filed: April 2, 2009
    Publication date: December 24, 2009
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shai Yarkoni, Ahmi Ben-Yehudah, Yehudith Azar, Rami Ishaq Aqeilan, Ruth Belostotsky, Haya Lorberboum-Galski
  • Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities
    Publication number: 20080255339
    Abstract: The present invention relates to chimeric proteins with cell-targeting specificity and apoptosis-inducing activities. In particular, the invention is illustrated by examples of chimeric proteins including recombinant chimeric proteins between a gonadoptropin releasing hormone (GnRH) and an apoptosis-inducing moiety, such as a pro-apoptotic member of Bcl-2 family, such as Bik, Bax and Bak, or caspases, such as caspase-3. The chimeric proteins specifically target cells expressing a GnRH-binding site, such as adenocarcinoma cells, and induce cell-specific apoptosis.
    Type: Application
    Filed: May 29, 2002
    Publication date: October 16, 2008
    Inventors: Shai Yarkoni, Ahmi Ben-Yehudah, Yehudith Azar, Rami Ishaq Aqeilan, Ruth Belostotsky, Haya Lorberboum-Galski
  • Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities
    Publication number: 20050079154
    Abstract: The present invention relates to chimeric proteins with cell-targeting specificity and apoptosis-inducing activities. In particular, the invention is illustrated by examples of chimeric proteins of a cell-targeting moiety and an apoptosis-inducing moiety, such as cytochrome C, a caspase, e.g., Caspase3, DNA fragmentation factor (DFF40), a fragment of an apoptotic protein of the Bcl-2 family, such as Bik, Bax and Bak, etc,. The chimeric proteins specifically target cells expressing a binding site for the target protein, and induce cell-specific apoptosis.
    Type: Application
    Filed: August 13, 2003
    Publication date: April 14, 2005
    Inventors: Shai Yarkoni, Ahmi Ben-Yehudah, Yehudith Azar, Rami Aqeilan, Ruth Belostotsky, Haya Lorberboum-Galski
  • Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities
    Patent number: 6645490
    Abstract: The present invention relates to chimeric proteins with cell-targeting specificity and apoptosis-inducing activities. In particular, the invention is illustrated by a recombinant chimeric protein between human interleukin-2 (IL2) and Bax. The chimeric protein specifically targets IL2 receptor (IL2R)-expressing cells and induces cell-specific apoptosis.
    Type: Grant
    Filed: March 2, 1998
    Date of Patent: November 11, 2003
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shai Yarkoni, Ahmi Ben-Yehudah, Yehudith Azar, Rami Ishaq Aqeilan, Ruth Belostotsky, Haya Lorberboum-Galski
  • CHIMERIC PROTEINS WITH CELL-TARGETING SPECIFICITY AND APOPTOSIS-INDUCING ACTIVITIES
    Publication number: 20020090374
    Abstract: The present invention relates to chimeric proteins with cell-targeting specificity and apoptosis-inducing activities. In particular, the invention is illustrated by a recombinant chimeric protein between human interleukin-2 (IL2) and Bax. The chimeric protein specifically targets IL2 receptor (IL2R)-expressing cells and induces cell-specific apoptosis.
    Type: Application
    Filed: March 2, 1998
    Publication date: July 11, 2002
    Inventors: SHAI YARKONI, AHMI BEN-YEHUDAH, YEHUDITH AZAR, RAMI AQEILAN, RUTH BELOSTOTSKY, HAYA LORBERBOUM-GALSKI
  • Methods of cancer diagnosis using a chimeric toxin
    Patent number: 6140066
    Abstract: The present invention relates to methods for cancer diagnosis using a chimeric toxin. In particular, the invention relates to the use of a chimeric toxin composed of gonadotropin releasing hormone (GnRH) and Pseudomonas exotoxin A (PE) to detect a tumor-associated epitope expressed by human adenocarcinomas. Mutated GnRH-PE molecules that bind but do not kill tumor cells are exemplified.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: October 31, 2000
    Inventors: Haya Lorberboum-Galski, Shai Yarkoni, Ahmi Ben-Yehudah, Irina Marianovsky, Amotz Nechushtan