Abstract: The present invention provides an A-FABP neutralizing monoclonal antibody or antigen-binding fragment thereof and a preparation method and use thereof, which comprises: complementarity determining regions 1 to 3 of a heavy chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:1-3, respectively, and/or complementarity determining regions 1-3 of the light chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:4-6. This monoclonal antibody is highly specific for A-FABP and has no cross-reactivity with human and mouse epidermal FABP and heart FABP; it has a good binding affinity for human A-FABP and mouse A-FABP; and its treatment alleviates MCAO-induced ischemic stroke injury in mice, which is associated with alleviated BBB disruption and reduced activation of pro-inflammatory JNK signaling; treatment of healthy mice for 21 days does not change physiological parameters, indicating its safety.

Abstract: A control method of a switching circuit, a control circuit of the switching circuit and the switching circuit are provided. The control circuit includes a slope buffer and a first operational amplifier. The slope buffer receives a first voltage reference, and controls slopes of a rising edge and a falling edge to generate a second voltage reference. The first operational amplifier receives an output feedback voltage and a reference voltage, and performs an operational amplification to obtain a compensation voltage. When the first voltage reference has the falling edge, the reference voltage is coupled to the first voltage reference through a first switch, and the second voltage reference is coupled to an output voltage through a second switch. When the first voltage reference has the rising edge, the reference voltage is coupled to the second voltage reference through a third switch.

Abstract: An inductive current simulation circuit of a switching circuit, an inductive current simulation method of the switching circuit, and a switched-mode power supply are provided. The inductive current simulation method includes the following steps: based on an error amplification circuit, performing, by the error amplification circuit, an error amplification on a first sampling signal representing a current of a synchronous rectifier and a second sampling signal representing an inductive current simulation signal when the synchronous rectifier is turned on to obtain an error amplification signal; and reconstructing an inductive current according to the error amplification signal when the synchronous rectifier is turned on and a first current when a main power transistor is turned on to obtain the inductive current simulation signal.

Abstract: Disclosed is a switch protection circuit and a power converter, configured to set upper and lower limit-value current signals which can be adjusted along with an input voltage, so that instantaneous power of a main power switch can be prevented from being too high, and the main power switch can always be operated within a safe operating range, thereby solving the problem that the power converter is easy to be damaged in applications under a high-current circumstance.

Abstract: A system and a method for an integrated test on a primary-secondary pole-mounted breaker. The method includes: establishing an electrical connection between the system and the primary-secondary pole-mounted breaker; establishing a communication connection between the system and the primary-secondary pole-mounted breaker; applying, by the system, a voltage signal and a current signal to the primary-secondary pole-mounted breaker through the electrical connection, to generate a voltage and a current on the primary-secondary pole-mounted breaker; collecting, by the system, signals of the voltage and the current fed back from the primary-secondary pole-mounted breaker through the communication connection; performing, by the system, an integrated accuracy test and an integrated protection test; outputting a test result of the accuracy test and a test result of the integrated protection test to the industrial control machine, to generate the test report.

Abstract: A control method of a switching circuit, a control circuit of the switching circuit and the switching circuit are provided. The control circuit includes a slope buffer and a first operational amplifier. The slope buffer receives a first voltage reference, and controls slopes of a rising edge and a falling edge to generate a second voltage reference. The first operational amplifier receives an output feedback voltage and a reference voltage, and performs an operational amplification to obtain a compensation voltage. When the first voltage reference has the falling edge, the reference voltage is coupled to the first voltage reference through a first switch, and the second voltage reference is coupled to an output voltage through a second switch. When the first voltage reference has the rising edge, the reference voltage is coupled to the second voltage reference through a third switch.

Abstract: An inductive current simulation circuit of a switching circuit, an inductive current simulation method of the switching circuit, and a switched-mode power supply are provided. The inductive current simulation method includes the following steps: based on an error amplification circuit, performing, by the error amplification circuit, an error amplification on a first sampling signal representing a current of a synchronous rectifier and a second sampling signal representing an inductive current simulation signal when the synchronous rectifier is turned on to obtain an error amplification signal; and reconstructing an inductive current according to the error amplification signal when the synchronous rectifier is turned on and a first current when a main power transistor is turned on to obtain the inductive current simulation signal.

Abstract: A control method and a control circuit for a switching power supply circuit and the switching power supply circuit. The switching power supply circuit includes a main switching transistor, a synchronous rectifier and an inductive element. When a switching signal indicates that the synchronous rectifier is turned from on to off, and the main switching transistor is turned from off to on, a gate voltage of the synchronous rectifier is pulled down to be lower than a threshold voltage of the synchronous rectifier and higher than a zero voltage by using a resistor-capacitor delay effect and timing is started. When a gate voltage of the main switching transistor is detected to rise to a first voltage or the timing reaches a first time, the gate voltage of the synchronous rectifier is pulled down to the zero voltage.

Abstract: A receiver optical subassembly includes an optical receiving housing, and a first optical receiver, a second optical receiver, and a first glass are packaged in the optical receiving housing. The first glass is disposed obliquely relative to an optical receiving direction, and includes a light incident surface and a light emergent surface. The first optical receiver and the second optical receiver are opposite to the light emergent surface of the first glass. A first light splitting film is disposed on the light emergent surface of the first glass. A first reflective film is disposed on the light emergent surface of the first glass. The first light splitting film can transmit an optical signal of a first wavelength and reflect an optical signal of a second wavelength.

Abstract: A control method and a control circuit for a switching power supply circuit and the switching power supply circuit. The switching power supply circuit includes a main switching transistor, a synchronous rectifier and an inductive element. When a switching signal indicates that the synchronous rectifier is turned from on to off, and the main switching transistor is turned from off to on, a gate voltage of the synchronous rectifier is pulled down to be lower than a threshold voltage of the synchronous rectifier and higher than a zero voltage by using a resistor-capacitor delay effect and timing is started. When a gate voltage of the main switching transistor is detected to rise to a first voltage or the timing reaches a first time, the gate voltage of the synchronous rectifier is pulled down to the zero voltage.

Abstract: Adiponectin-expressing thymocytes and compositions comprising the thymocytes are provided. Methods are provided for using the adiponectin-expressing thymocytes for metabolic regulation and treatment of hyperproliferative diseases.

Abstract: A power device driving method and a driving circuit for a switching circuit having a main switching transistor, a synchronous rectifier, and an inductive element. When a switching signal indicates that the synchronous rectifier is turned from on to off and the main switching transistor is turned from off to on, a gate voltage of the synchronous rectifier is pulled down to be lower than a threshold voltage of the synchronous rectifier and higher than zero voltage by a body effect of a MOS transistor, and timing is started. When detecting that a gate voltage of the main switching transistor rises to a first voltage or the timing reaches a first time, the gate voltage of the synchronous rectifier is pulled down to the zero voltage.

Abstract: A system and a method for an integrated test on a primary-secondary pole-mounted breaker. The method includes: establishing an electrical connection between the system and the primary-secondary pole-mounted breaker; establishing a communication connection between the system and the primary-secondary pole-mounted breaker; applying, by the system, a voltage signal and a current signal to the primary-secondary pole-mounted breaker through the electrical connection, to generate a voltage and a current on the primary-secondary pole-mounted breaker; collecting, by the system, signals of the voltage and the current fed back from the primary-secondary pole-mounted breaker through the communication connection; performing, by the system, an integrated accuracy test and an integrated protection test; outputting a test result of the accuracy test and a test result of the integrated protection test to the industrial control machine, to generate the test report.

Abstract: The invention provides the use of non-polyaminated lipocalin-2 and/or polyaminated lipocalin-2 as biomarkers for cardiometabolic disease as well as antibodies, assays and devices related to these biomarkers.

Abstract: A switching power supply using a power switch, and a drive circuit therefor are disclosed. This circuit includes a power supplying capacitor with distal end connected with control terminal of the power switch and proximal end to receive a voltage regulation signal generated by a first control signal and a pulse signal. The power switch may be turned on or off, depending on whether the first control signal is placed in a first state during which the voltage regulation signal is in pulse state with the voltage at said distal end made effective, or in a second state during which the voltage regulation signal is in low-level state with the voltage at said distal end made ineffective. A continuous drive and power supplying for the switching power supply is realized, and the capacitance of said capacitor is small, thereby facilitating circuit integration.

Abstract: Methods and compositions for identifying autoimmune diabetes are provided. One aspect provides a method for the evaluation of risk and progression of autoimmune diabetes in mammalian subjects. The method includes measuring the enzymatic activities and/or protein concentrations of neutrophil elastase and proteinase 3 in a subject and comparing the measured levels of these proteases to respective reference levels.

Abstract: Methods and compositions for identifying autoimmune diabetes are provided. One aspect provides a method for the evaluation of risk and progression of autoimmune diabetes in mammalian subjects. The method includes measuring the enzymatic activities and/or protein concentrations of neutrophil elastase and proteinase 3 in a subject and comparing the measured levels of these proteases to respective reference levels.

Abstract: Methods and compositions for identifying and treating obesity and obesity-induced metabolic disorders are provided. One aspect provides a method for the evaluation of risk and progression of glucose tolerance, insulin resistance and Type 2 diabetes in mammalian subjects. The method includes measuring the concentration of circulating lipocalin-2 in a subject and comparing the measured level to lipocalin-2 to a reference level. Another aspect provides methods of treating insulin resistance, type 2 diabetes and other related complications by administering to a patient a composition that can reduce the circulating levels of lipocalin-2, for example a lipocalin-2 antagonist.

Abstract: The invention provides methods and reagents for regulation of metabolic events, such as those mediated by adiponectin and adiponectin agonists. The invention also provides screening assays for identification of biologically active agents, diagnostic and therapeutic agents, and other methods and reagents.

Abstract: Methods and apparatus are disclosed for the measurement of lipocalin-2 in body fluids (including but not limited to blood, serum, plasma, urine, saliva, tear, etc.) by an assay such as an immunoassay or an immunotest for (1) the prediction of risk of future cardiovascular diseases; and (2) the determination of the likelihood that certain individuals will benefit to a greater or lesser extent from the use of certain treatments designed to prevent and/or treat cardiovascular diseases.