Patents by Inventor Aichen Wang
Aichen Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11861897Abstract: The present disclosure provides a portable apparatus for detecting early crop diseases based on spatial frequency domain imaging. The apparatus includes an end cover, a spatial frequency domain imaging apparatus, a dark box body, a telescopic section, and an opening-and-closing apparatus connected in sequence. The detection method includes: putting a crop sample to be detected into the dark box body from a bottom; projecting structured light of sine grey scale patterns with different spatial frequencies to the crop sample; after the sine gray scale pattern is switched each time, acquiring, by a camera, a diffuse reflection image of a surface of the crop sample once; after capturing all diffuse reflection images, performing uniformity correction on the images, demodulating the images, and extracting an alternating current component; and inputting an alternating current component image to a trained disease detection model, and determining whether the crop sample has a disease.Type: GrantFiled: January 14, 2022Date of Patent: January 2, 2024Assignee: Jiangsu UniversityInventors: Aichen Wang, Huadong Cao, Binjie Gao, Lin Li, Xinhua Wei, Kun Tao
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Publication number: 20230326203Abstract: The present disclosure provides a portable apparatus for detecting early crop diseases based on spatial frequency domain imaging. The apparatus includes an end cover, a spatial frequency domain imaging apparatus, a dark box body, a telescopic section, and an opening-and-closing apparatus connected in sequence. The detection method includes: putting a crop sample to be detected into the dark box body from a bottom; projecting structured light of sine grey scale patterns with different spatial frequencies to the crop sample; after the sine gray scale pattern is switched each time, acquiring, by a camera, a diffuse reflection image of a surface of the crop sample once; after capturing all diffuse reflection images, performing uniformity correction on the images, demodulating the images, and extracting an alternating current component; and inputting an alternating current component image to a trained disease detection model, and determining whether the crop sample has a disease.Type: ApplicationFiled: January 14, 2022Publication date: October 12, 2023Applicant: Jiangsu UniversityInventors: Aichen WANG, Huadong CAO, Binjie GAO, Lin LI, Xinhua WEI, Kun TAO
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Patent number: 10568494Abstract: A terahertz endoscope suitable for intestinal tract lesion inspection and an inspection method are provided. The terahertz endoscope includes a combined tube body inserted into an intestinal tract, a terahertz signal enhancement module, a terahertz inspection module, and a real-time imaging module. The combined tube body mainly includes a sleeve tube (6), a sleeve head (7) and a hemispherical glass cover (8). The terahertz signal enhancement module mainly includes a tunable laser (2) and an optical fiber (9) installed in the sleeve tube (6). The terahertz inspection module mainly includes a terahertz wave detector (4), a terahertz wave transmitter (5), as well as a first stainless steel metal wire (12) and a second stainless steel metal wire (13) installed in the combined tube body.Type: GrantFiled: April 16, 2016Date of Patent: February 25, 2020Assignee: ZHEJIANG UNIVERSITYInventors: Lijuan Xie, Chen Wang, Yibin Ying, Aichen Wang, Yuxin Huang
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Publication number: 20180325366Abstract: A terahertz endoscope suitable for intestinal tract lesion inspection and an inspection method are provided. The terahertz endoscope includes a combined tube body inserted into an intestinal tract, a terahertz signal enhancement module, a terahertz inspection module, and a real-time imaging module. The combined tube body mainly includes a sleeve tube (6), a sleeve head (7) and a hemispherical glass cover (8). The terahertz signal enhancement module mainly includes a tunable laser (2) and an optical fiber (9) installed in the sleeve tube (6). The terahertz inspection module mainly includes a terahertz wave detector (4), a terahertz wave transmitter (5), as well as a first stainless steel metal wire (12) and a second stainless steel metal wire (13) installed in the combined tube body.Type: ApplicationFiled: April 16, 2016Publication date: November 15, 2018Applicant: ZHEJIANG UNIVERSITYInventors: Lijuan Xie, Chen Wang, Yibin Ying, Aichen Wang, Yuxin Huang
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Patent number: 9809589Abstract: The present invention belongs to the technical field of medicines, and relates to a crystal form of a compound used as a mineralocorticoid receptor antagonist and a preparation method therefor, and in particular, to a method for preparing a compound 2-chloro-4-[(3S,3aR)-3-cyclopentyl-7-(4-hydroxypiperidin-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl]benzonitrile of formula (1); a crystal form thereof, a preparation method for the crystal form, and the use of the crystal form in the preparation of drugs for the treatment and/or prevention of renal injury or cardiovascular diseases.Type: GrantFiled: December 23, 2013Date of Patent: November 7, 2017Assignee: KBP BIOSCIENCES CO., LTD.Inventors: Chen Jiang, Aichen Wang, Dedong Zhang
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Publication number: 20170136023Abstract: The invention relates to a quinazoline derivative represented by the general formula (I), a pharmaceutical acceptable salt and a stereoisomer thereof as tyrosine kinase inhibitor, wherein R1, R2, R3, R3?, R4, R5, R6, X, L, T, Z and q are as defined in the specification. The invention also relates to a process for preparing the same, a pharmaceutical composition and a pharmaceutical formulation containing the derivative, use of the derivative for treating excessive proliferative diseases and chronic obstructive pulmonary disease and use of the derivative in the manufacture of a medicament for treating excessive proliferative diseases and chronic obstructive pulmonary disease.Type: ApplicationFiled: January 30, 2017Publication date: May 18, 2017Applicant: Xuanzhu Pharma Co., Ltd.Inventors: Frank Wu, Aichen Wang
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Patent number: 9642851Abstract: The present invention relates to a compound represented by general formula (I), a method for preparing said compound, a pharmaceutical formulation containing said compound, and the use of said compound in manufacture of a medicament for treating or preventing the fibrous degeneration disease and treating the excessive proliferation disease: wherein ring A, X, R1, R2, R3, R4, R5, R6, R7, R8, R9, a, b and n are defined as those in the description.Type: GrantFiled: December 6, 2013Date of Patent: May 9, 2017Assignee: KBP BioSciences Co., Ltd.Inventors: Hoyin Lo, Aichen Wang, Qian Zhang
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Patent number: 9586939Abstract: The invention relates to a quinazoline derivative represented by the general formula (I), a pharmaceutical acceptable salt and a stereoisomer thereof as tyrosine kinase inhibitor, wherein R1, R2, R3, R3?, R4, R5, R6, X, L, T, Z and q are as defined in the specification. The invention also relates to a process for preparing the same, a pharmaceutical composition and a pharmaceutical formulation containing the derivative, use of the derivative for treating excessive proliferative diseases and chronic obstructive pulmonary disease and use of the derivative in the manufacture of a medicament for treating excessive proliferative diseases and chronic obstructive pulmonary disease.Type: GrantFiled: May 28, 2012Date of Patent: March 7, 2017Assignee: XUANZHU PHARMA CO., LTD.Inventors: Frank Wu, Aichen Wang
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Patent number: 9487545Abstract: The present invention relates to a fused ring-containing oxazolidinone compound shown by general formula (I), a pharmaceutically acceptable salt thereof and a stereoisomer thereof, wherein R1, R2, R3, R4, R5, R6, A, B and C are as defined in the description. The present invention further relates to a method for preparing the compound, a pharmaceutical composition and a pharmaceutical formulation comprising the compound, and a use of the compound for the manufacture of a medicament for the treatment and/or prevention of infectious diseases and a use for the treatment and/or prevention of infectious diseases.Type: GrantFiled: September 29, 2012Date of Patent: November 8, 2016Assignee: Xuanzhu Pharma Co., Ltd.Inventors: Hui Zhang, Aichen Wang
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Patent number: 9359371Abstract: Disclosed are bicyclic group substituted pyrimidine compounds, pharmaceutical acceptable salts thereof or stereoisomers thereof. Also disclosed are preparation methods, pharmaceutical formulations, and pharmaceutical compositions of the compounds, and use of the compounds, pharmaceutical formulations, and pharmaceutical compositions for preparing a medicament for treating and/or preventing sexual dysfunction diseases and diseases with lower urinary tract symptoms.Type: GrantFiled: August 14, 2013Date of Patent: June 7, 2016Assignee: XUANZHU PHARMA CO., LTD.Inventors: Frank Wu, Aichen Wang
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Patent number: 9359344Abstract: The present invention relates to a biaryl heterocycle substituted oxazolidinone antibacterials shown by general formula (I), a pharmaceutically acceptable salt thereof, an isomer or a prodrug thereof, wherein R1, R2, R3, R4, R5, A and B are as defined in the description. The present invention further relates to a method for preparing the compound, a pharmaceutical composition and a pharmaceutical formulation comprising the compound, and a use of the compound in the manufacture of a medicament for the treatment and/or prevention of infectious diseases and a use for the treatment and/or prevention of infectious diseases.Type: GrantFiled: September 28, 2012Date of Patent: June 7, 2016Assignee: Xuanzhu Pharma Co., Ltd.Inventors: Frank Wu, Aichen Wang
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Publication number: 20150336950Abstract: The present invention belongs to the technical field of medicines, and relates to a crystal form of a compound used as a mineralocorticoid receptor antagonist and a preparation method therefor, and in particular, to a method for preparing a compound 2-chloro-4-[(3S,3aR)-3-cyclopentyl-7-(4-hydroxypiperidin-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl]benzonitrile of formula (1); a crystal form thereof, a preparation method for the crystal form, and the use of the crystal form in the preparation of drugs for the treatment and/or prevention of renal injury or cardiovascular diseases.Type: ApplicationFiled: December 23, 2013Publication date: November 26, 2015Applicant: KBP BIOSCIENCES CO., LTD.Inventors: Chen JIANG, Aichen WANG, Dedong ZHANG
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Publication number: 20150306095Abstract: The present invention relates to a compound represented by general formula (I), a method for preparing said compound, a pharmaceutical formulation containing said compound, and the use of said compound in manufacture of a medicament for treating or preventing the fibrous degeneration disease and treating the excessive proliferation disease: wherein ring A, X, R1, R2, R3, R4, R5, R6, R7, R8, R9, a, b and n are defined as those in the description.Type: ApplicationFiled: December 6, 2013Publication date: October 29, 2015Applicant: KBP Biosciences Co., Ltd.Inventors: Hoyin Lo, Aichen Wang, Qian Zhang
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Publication number: 20150232474Abstract: Disclosed are bicyclic group substituted pyrimidine compounds, pharmaceutical acceptable salts thereof or stereoisomers thereof. Also disclosed are preparation methods, pharmaceutical formulations, and pharmaceutical compositions of the compounds, and use of the compounds, pharmaceutical formulations, and pharmaceutical compositions for preparing a medicament for treating and/or preventing sexual dysfunction diseases and diseases with lower urinary tract symptoms.Type: ApplicationFiled: August 14, 2013Publication date: August 20, 2015Inventors: Frank Wu, Aichen Wang
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Patent number: 8980904Abstract: The present invention pertains to the field of medical technology, and particularly relates to a heterocyclic substituted pyrimidine compound represented by General Formula (I) and its pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description, the present invention also relates to a preparation method of the compound, a pharmaceutical composition containing the compound, and a use of the compound and the pharmaceutical composition in preparation of a medicine for enhancing a cGMP signal transduction function or a medicine for treating or preventing sexual dysfunction and diseases with lower urinary tract symptoms.Type: GrantFiled: July 19, 2012Date of Patent: March 17, 2015Assignee: Xuanzhu Pharma Co., Ltd.Inventors: Yongqian Wu, Aichen Wang
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Publication number: 20140288063Abstract: The present invention pertains to the field of medical technology, and particularly relates to a heterocyclic substituted pyrimidine compound represented by General Formula (I) and its pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description, the present invention also relates to a preparation method of the compound, a pharmaceutical composition containing the compound, and a use of the compound and the pharmaceutical composition in preparation of a medicine for enhancing a cGMP signal transduction function or a medicine for treating or preventing sexual dysfunction and diseases with lower urinary tract symptoms.Type: ApplicationFiled: July 19, 2012Publication date: September 25, 2014Applicant: Xuanzhu Pharma Co., Ltd.Inventors: Yongqian Wu, Aichen Wang
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Publication number: 20140243288Abstract: The present invention relates to a fused ring-containing oxazolidinone compound shown by general formula (I), a pharmaceutically acceptable salt thereof and a stereoisomer thereof, wherein R1, R2, R3, R4, R5, R6, A, B and C are as defined in the description. The present invention further relates to a method for preparing the compound, a pharmaceutical composition and a pharmaceutical formulation comprising the compound, and a use of the compound for the manufacture of a medicament for the treatment and/or prevention of infectious diseases and a use for the treatment and/or prevention of infectious diseases.Type: ApplicationFiled: September 29, 2012Publication date: August 28, 2014Inventors: Hui Zhang, Aichen Wang
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Publication number: 20140235584Abstract: The present invention relates to a biaryl heterocycle substituted oxazolidinone antibacterials shown by general formula (I), a pharmaceutically acceptable salt thereof, an isomer or a prodrug thereof, wherein R1, R2, R3, R4, R5, A and B are as defined in the description. The present invention further relates to a method for preparing the compound, a pharmaceutical composition and a pharmaceutical formulation comprising the compound, and a use of the compound in the manufacture of a medicament for the treatment and/or prevention of infectious diseases and a use for the treatment and/or prevention of infectious diseases.Type: ApplicationFiled: September 28, 2012Publication date: August 21, 2014Applicant: Xuanzhu Pharma Co., Ltd.Inventors: Frank Wu, Aichen Wang
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Publication number: 20140161801Abstract: The invention relates to a quinazoline derivative represented by the general formula (I), a pharmaceutical acceptable salt and a stereoisomer thereof as tyrosine kinase inhibitor, wherein R1, R2, R3, R3?, R4, R5, R6, X, L, T, Z and q are as defined in the specification. The invention also relates to a process for preparing the same, a pharmaceutical composition and a pharmaceutical formulation containing the derivative, use of the derivative for treating excessive proliferative diseases and chronic obstructive pulmonary disease and use of the derivative in the manufacture of a medicament for treating excessive proliferative diseases and chronic obstructive pulmonary disease.Type: ApplicationFiled: May 28, 2012Publication date: June 12, 2014Applicant: XUANZHU PHARMA CO., LTD.Inventors: Frank Wu, Aichen Wang