Abstract: Disclosed herein are methods for treating, ameliorating, and/or preventing Alzheimer's Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof, based upon a combination of APOE4 status and disease severity.

Abstract: A method, system, and computer-usable medium are disclosed, comprising: initiating a web transaction between an endpoint device and a target web server; automatically switching between a first communication mode and a second communication mode in response to one or more communication performance conditions associated with conducting the web transaction, where the endpoint device communicates with the target web server using an intermediate proxy server in the first communication mode; and the endpoint device communicates with the target web server without using the intermediate proxy server in the second communication mode. Other embodiments include corresponding computer systems, apparatus, and computer programs recorded on one or more computer storage devices, each configured to perform the actions of the methods.

Abstract: Provided herein are methods for using hippocampal volume and/or cortical thickness in human subjects as a predictor of Alzheimer's disease (AD) and treating subjects who are determined to be at risk for AD or a decline in cognitive impairment.

Abstract: A method, system, and computer-usable medium are disclosed for executing operations, including initiating a web transaction between an endpoint device and a target web server and automatically switching between multiple communication modes in response to one or more communication mode security policies associated with conducting the web transaction. The multiple communication modes include a first communication mode in which the endpoint device communicates with the target web server using an intermediate proxy server, and a second communication mode in which the endpoint device communicates with the target web server without using the intermediate proxy server. Other embodiments include corresponding computer systems, apparatus, and computer programs recorded on one or more computer storage devices, each configured to perform the actions of the methods.

Abstract: A method, system, and computer-usable medium are disclosed, comprising: initiating a web transaction between an endpoint device and a target web server; automatically switching between a first communication mode and a second communication mode in response to one or more communication performance conditions associated with conducting the web transaction, where the endpoint device communicates with the target web server using an intermediate proxy server in the first communication mode; and the endpoint device communicates with the target web server without using the intermediate proxy server in the second communication mode. Other embodiments include corresponding computer systems, apparatus, and computer programs recorded on one or more computer storage devices, each configured to perform the actions of the methods.

Abstract: Disclosed herein are methods for treating, ameliorating, and/or preventing Alzheimer's Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof based upon a combination of APOE4 status and disease severity.

Abstract: Disclosed herein are methods for treating, ameliorating, and/or preventing Alzheimer's Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof based upon a combination of APOE4 status and disease severity.

Abstract: Disclosed herein are methods for treating, ameliorating, and/or preventing Alzheimer's Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof based upon a combination of APOE4 status and disease severity.

Abstract: The present invention features polymorphisms in genes encoding cardiac potassium channels that are predictive of a subject's susceptibility to developing a drug-induced arrhythmia. The present invention also provides methods of genotyping subjects to determine whether they carry the polymorphisms.