Patents by Inventor Aideen Ryan

Aideen Ryan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR TREATMENT OF CANCER
    Publication number: 20210186999
    Abstract: A method of treating cancer is provided wherein the method comprises inhibiting or reducing sialylation of specifically Mesenchymal Stromal Cells (MSCs) to inhibit MSC immunosuppression and restore T cell proliferation in cancer. The method may comprise administering a sialyltransferase inhibitor (e.g. 3Fax-Peracetyl Neu5Ac) or sialidase. Also described is administration of MSCs which have been manipulated prior to administration to remove sialic acids and use of a small molecule or blocking antibody which blocks interactions between MSC-sialic acid and lectins, such as Siglec 7, and/or blocks interactions between MSC-lectins and sialic acid.
    Type: Application
    Filed: October 31, 2018
    Publication date: June 24, 2021
    Inventors: Michael O'Dwyer, Thomas Ritter, Aideen Ryan, Kevin Lynch
  • Combination Therapies for CD38-Positive Hematological Malignances with ANTI-CD38 Antibodies and Cyclophosphamide
    Publication number: 20180117150
    Abstract: Provided are combination therapies comprising an anti-CD38 antibody and cyclophosphamide for CD38-positive hematological malignancies.
    Type: Application
    Filed: October 31, 2017
    Publication date: May 3, 2018
    Inventors: Michael O'Dwyer, Aideen Ryan