Abstract: System for cooled endocardial injection are disclosed. An example system may include a steerable catheter having a first lumen therein. The system may include a cooling circuit disposed along at least a portion of the steerable catheter, the cooling circuit having a fluid inlet, a fluid outlet, a proximal end, and a distal end. The cooling circuit may include a first lumen section extending distally along the steerable catheter and including the fluid inlet and a second lumen section extending proximally along the steerable catheter and including the fluid outlet. The system may include an injection catheter disposed in the first lumen. The injection catheter may be configured to deliver a cooled therapeutic fluid to endocardial tissue.

Abstract: A delivery catheter as disclosed herein may be configured in various embodiments to minimize the potential for entanglement between cardiac repair components such as between sutures and coupled anchors. In various embodiments this is achieved by separating an anchor translation channel from a suture translation channel while maintaining the coupling between the anchor and the suture.

Abstract: Devices, systems, and method for treating abdominal aortic aneurysms are disclosed. An illustrative system can include an occlusion catheter with an elongate catheter shaft. The elongate catheter shaft can have a first expandable member and a second expandable member. The elongate catheter shaft can have a therapeutic fluid infusion port disposed in an isolated area between the first expandable member and the second expandable member, where the occlusion catheter is configured to infuse a therapeutic fluid via the elongate catheter shaft and through the therapeutic fluid infusion port to a position proximate to an abdominal aortic aneurysm in the isolated area. The illustrative system including an elongate light-emitting catheter including a light-emitting element, wherein the light-emitting element is configured to emit light and be disposed at the position.

Abstract: Medical devices and methods for using medical devices are disclosed. An example method for performing percutaneous nephrolithotomy includes registering an optical tracking system to a global coordinate system, registering a fluoroscope to the global coordinate system, generating a first image of a treatment area of a patient using the fluoroscope, generating a second image of the treatment area of the patient using the fluoroscope, selecting a target treatment point within the treatment area on the first image, the second image or both the first image and the second image and overlaying a medical instrument proposed guidance line on the first image, the second image or both the first image and the second image, wherein the medical instrument proposed guidance line depicts a proposed insertion pathway from an insertion point on the patient's body to the target treatment point.

Abstract: An ostomy device an implant and a balloon. The implant is sized and shaped for implantation in a hole in an abdomen. The implant comprises a tubular body defining a channel extending from a first end to a second end. The first end is configured to interface with a lumen interior to the abdomen. The second end is configured to provide a path from the lumen through the channel to an exterior of the abdomen. The implant is configured to be attached to the hole or to skin adjacent to the hole. The balloon is attached to the first end of the implant. The balloon is deflatable into a closed state to prevent a flow of waste from the lumen through the path. The balloon is inflatable into an open state to allow the flow of the waste from the lumen through the path.

Abstract: A system for treating mitral regurgitation may include an outer sheath having a lumen extending to a distal end of the outer sheath, an intermediate sheath slidably disposed within the lumen of the outer sheath, the intermediate sheath having a lumen extending to a distal end of the intermediate sheath, and an inner sheath slidably disposed within the lumen of the intermediate sheath, wherein the inner sheath includes a first anchor disposed within a lumen of the inner sheath, the first anchor being configured to penetrate and secure to a first papillary muscle. The intermediate sheath may include a tissue grasping mechanism at the distal end of the intermediate sheath, the tissue grasping mechanism being configured to hold and stabilize the first papillary muscle for penetration and securement of the first anchor to the first papillary muscle.

Abstract: Devices, systems, and methods for treating stones in anatomical structures are disclosed. A device may include an elongate member and a tubular member extending distally from the elongate member. The elongate member may define one or more lumens with an opening at a distal end of the elongate member. The tubular member may be configured to collapse to a pre-determined shape when in a relaxed state and expand in response to receiving an object. The device may be used with a scope, such as a ureteroscope, lithotripsy devices, and/or other medical devices or systems.

Abstract: System for endocardial injection are disclosed. An example system may include a first steerable catheter having a first lumen formed therein. A second steerable catheter may be disposed within the first lumen. The second steerable catheter may have a second lumen formed therein. An injection catheter may be disposed within the second lumen. The injection catheter may have a distal end region. The distal end region may include an imaging section and a needle section. The system may include an imaging device configured to be disposed within the imaging section.

Abstract: Method and systems for closing an opening formed during a medical procedure are disclosed. An example method may include advancing a needle through patient tissue to form an opening into a bile duct region, performing an intervention within the bile duct region, and advancing an embolic gel into the opening to close the opening.

Abstract: A medical stent includes an expandable structure that is moveable between a collapsed configuration for delivery and an expanded configuration for deployment, the expandable structure in the expanded configuration defining a relaxed diameter. The expandable structure retains its relaxed diameter along portions of the expandable structure that are not constrained by contact with vessel walls after deployment. Portions of the expandable structure that are compressed by contact with vessel walls after deployment are caused to move to a reduced diameter less than the relaxed diameter along portions. The compressed portions of the expandable structure may help prevent plaque from breaking loose. Uncompressed portions of the expandable structure may allow blood flow therethrough.

Abstract: A medical device may comprise a distal tip having a viewing element, a lighting element, and at least one feature configured to removably couple the distal tip to a shaft. The medical device may also comprise a working channel coupled to the distal tip and defining a central lumen configured to receive a tool. A wall of the working channel may define at least one additional lumen. The working channel may be configured to be removably inserted into the shaft. The medical device may also comprise at least one of a wire, a cable, or a conduit passing through the at least one additional lumen.

Abstract: A medical device may comprise a distal tip having a viewing element, a lighting element, and at least one feature configured to removably couple the distal tip to a shaft. The medical device may also comprise a working channel coupled to the distal tip and defining a central lumen configured to receive a tool. A wall of the working channel may define at least one additional lumen. The working channel may be configured to be removably inserted into the shaft. The medical device may also comprise at least one of a wire, a cable, or a conduit passing through the at least one additional lumen.

Abstract: An implant system and method of delivery includes a catheter system including a sling catheter having a plurality of distal openings and a delivery catheter, disposed within the sling catheter and having a distal port. Suture coupled anchors may be sequentially delivered by the delivery catheter to a cardiac treatment site by aligning the port of the delivery catheter with different openings of the sling catheter and pushing the anchor through the port and the sling catheter to embed the anchor into cardiac tissue such as tissue of a papillary muscle. Each anchor may have a linear configuration for translation within the delivery catheter and a biased configuration that inhibits its reentry into the sling catheter once deployed. Once all anchors are deployed, the suture may be tightened, the anchored portion of the sling catheter may be detached, and the catheter system withdrawn.

Abstract: A medical device may include a main shaft extending from a proximal end to a distal end; an actuator at a proximal portion of the medical device; an end effector positioned at a distal end of the main shaft and comprising a first jaw and a second jaw; a motor; and a torque amplification system. The torque amplification system may include a driveshaft coupled to the motor; a spring coupled to the driveshaft and configured to expand or contract in a proximal or a distal direction relative to the driveshaft; a hammer moveably coupled to the driveshaft; and an anvil coupled to the end effector and abutting the hammer. The anvil may be configured to provide a rotational power output to the end effector to move the first jaw and/or the second jaw.

Abstract: An implantable device for encapsulating cells includes one or more cell encapsulation layers. Each of the cell encapsulation layers includes a first membrane that is semipermeable, a second membrane that is semipermeable, and a first plurality of weld lines. The second membrane is attached to the first membrane by the first plurality of weld lines. The first membrane, the second membrane, and the first plurality of weld lines define at least one cell channel for encapsulating cells. The cell encapsulation device is configurable between a collapsed configuration and an inflated configuration.

Abstract: A motorized control system for a medical device may include a control assembly including a first body with a cradle assembly and a second body moveably coupled to the first body. The cradle assembly may be configured to removably couple to the medical device. The second body may include a gear assembly, a first motor configured to drive a first gear of the gear assembly, and a second motor configured to drive a second gear of the gear assembly. The control assembly may be configured to transition between an open configuration and a closed configuration. The gear assembly may be configured to receive a plurality of knobs of the medical device in the closed configuration. The first motor may be configured to drive the first gear to rotate a first knob. The second motor may be configured to drive the second gear to rotate a second knob.

Abstract: A medical device includes a handle including a stationary body, a first movable body, and a second movable body; a control member coupled to the second movable body; an intermediate sheath coupled to the first movable body; an external sheath coupled to the stationary body; and an end effector. The end effector includes a first loop and a second loop. The first loop includes a first arm and a second arm, and the first arm is coupled to the intermediate sheath. The second arm is coupled to the control member, and the second arm includes a first plurality of teeth. The second loop includes a third arm and a fourth arm. The third arm is coupled to the intermediate sheath, and the fourth arm is coupled to the control member. The fourth arm includes a second plurality of teeth.

Abstract: An implant system and method of delivery includes a catheter system including a sling catheter having a plurality of distal openings and a delivery catheter, disposed within the sling catheter and having a distal port. Suture coupled anchors may be sequentially delivered by the delivery catheter to a cardiac treatment site by aligning the port of the delivery catheter with different openings of the sling catheter and pushing the anchor through the port and the sling catheter to embed the anchor into cardiac tissue such as tissue of a papillary muscle. Each anchor may have a linear configuration for translation within the delivery catheter and a biased configuration that inhibits its reentry into the sling catheter once deployed. Once all anchors are deployed, the suture may be tightened, the anchored portion of the sling catheter may be detached, and the catheter system withdrawn.

Abstract: Medical devices and methods for using medical devices are disclosed. An example medical device includes a catheter having a proximal end region and a distal tip and an array of sealed chambers disposed along the distal tip, wherein each of the chambers includes a distal membrane disposed along an outer surface of the distal tip and a proximal membrane extending radially inward from the outer surface. Further, each proximal membrane is configured to shift between a first position and an expanded position in response to a change in pressure within the chamber.

Abstract: A cell encapsulation device for implantation in a body includes one or more cell encapsulation layers, each of the one or more cell encapsulation layers including at least one membrane and a guide tube. The at least one membrane is semipermeable. The least one membrane forms a chamber for encapsulating cells and at least one access port through the at least one membrane. The guide tube extends into the chamber from the at least one access port. The guide tube includes a porous wall along at least a portion of its length. The guide tube is capable of guiding movement of a catheter within the chamber.