Patents by Inventor Aidong Han

Aidong Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecules modulator of epigenetic regulation and their therapeutic applications
    Patent number: 9750731
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: September 5, 2017
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Lin Chen, Nimanthi Jayathilaka, Aidong Han, Nicos Petasis
  • Small Molecules Modulator of Epigenetic Regulation and Their Therapeutic Applications
    Publication number: 20150150860
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3.
    Type: Application
    Filed: August 21, 2014
    Publication date: June 4, 2015
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Lin CHEN, Nimanthi JAYATHILAKA, Aidong HAN, Nicos PETASIS
  • SMALL MOLECULE MODULATORS OF EPIGENETIC REGULATION AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20140343101
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3.
    Type: Application
    Filed: February 26, 2014
    Publication date: November 20, 2014
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Lin Chen, Nimanthi Jayathilaka, Aidong Han, Nicos A. Petasis
  • Small molecules modulator of epigenetic regulation and their therapeutic applications
    Patent number: 8846932
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: September 30, 2014
    Assignee: University of Southern California
    Inventors: Lin Chen, Nimanthi Jayathilaka, Aidong Han, Nicos A. Petasis
  • Small molecules modulator of epigenetic regulation and their therapeutic applications
    Patent number: 8697729
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: April 15, 2014
    Assignee: University of Southern California
    Inventors: Lin Chen, Nimanthi Jayathilaka, Aidong Han, Nicos Petasis
  • Small Molecules Modulator of Epigenetic Regulation and Their Therapeutic Applications
    Publication number: 20130281703
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.
    Type: Application
    Filed: March 13, 2013
    Publication date: October 24, 2013
    Inventors: Lin CHEN, Nimanthi JAYATHILAKA, Aidong HAN, Nicos A. PETASIS
  • Small Molecules Modulator of Epigenetic Regulation and Their Therapeutic Applications
    Publication number: 20110275674
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.
    Type: Application
    Filed: November 5, 2009
    Publication date: November 10, 2011
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Lin Chen, Nimanthi Jayathilaka, Aidong Han, Nicos A. Petasis
  • Three-dimensional structures of HDAC9 and Cabin1 and compound structures and methods related thereto
    Publication number: 20060160201
    Abstract: Disclosed are the three-dimensional structures of two complexes: a Cabin1/MEF2B/DNA complex and a MITR/MEF2B/DNA complex. Also disclosed are methods of using such structures and models derived therefrom in structure-based design methods to identify regulators of the interaction of MEF2 with its cognate ligands/corepressors, to compounds that can be designed or identified based on the knowledge of such structures and models, and to methods of using such compounds in therapeutic methods. Also disclosed are peptide and non-peptide regulatory compounds that regulate, and preferably inhibit, MEF2.
    Type: Application
    Filed: October 14, 2005
    Publication date: July 20, 2006
    Inventors: Lin Chen, Aidong Han, Ju He