Patents by Inventor Aifang CHENG

Aifang CHENG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DISCOVERY OF NOVEL TRPV1 CHANNEL BLOCKERS BY HIGH-THROUGHPUT SCREENING OF MARINE NATURAL PRODUCTS
    Publication number: 20240358734
    Abstract: The subject invention pertains to hexacyclic xanthones isolated from marine bacteria. These chrexanthomycins are effective TRPV1 inhibitors that are effective as analgesics.
    Type: Application
    Filed: April 26, 2024
    Publication date: October 31, 2024
    Inventors: Peiyuan QIAN, Pingbo HUANG, Wenkang YE, Sin Tung LUI, Qirui ZHAO, Aifang CHENG
  • Compounds as potential therapeutic agents targeting various neurodegenerative diseases
    Patent number: 11820762
    Abstract: The subject invention pertains to compositions and methods for treating neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), multiple sclerosis, epilepsy, stroke, alcohol withdrawal, progressive supranuclear palsy (PSP), Pick's disease (PiD), corticobasal degeneration (CBD), frontotemporal dementia or parkinsonism linked to chromosome 17 (FTDP-17). The methods of the subject invention further relate to methods of fermentation of bacterial cells and methods of tautomerization of the subject compounds.
    Type: Grant
    Filed: September 15, 2021
    Date of Patent: November 21, 2023
    Assignees: The Hong Kong University of Science and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
    Inventors: Pei-Yuan Qian, Aifang Cheng, Changdong Liu, Wenkang Ye, Guang Zhu
  • Albofungin and its derivatives specifically recognize HIV-1 LTR-III G-quadruplex
    Patent number: 11787817
    Abstract: The subject invention pertains to compositions comprising albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo. The subject invention further pertains to methods of treating a subject with HIV using albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo.
    Type: Grant
    Filed: June 1, 2022
    Date of Patent: October 17, 2023
    Assignees: The Hong Kong University of Science and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
    Inventors: Peiyuan Qian, Aifang Cheng, Changdong Liu, Wenkang Ye, Guang Zhu
  • POTENT ANTIFOULING AGENTS ALBOFUNGINS TARGET MULTIPLE FOULING ORGANISMS
    Publication number: 20230086634
    Abstract: The present invention provides potent antibiofilm and antifouling compounds albofungin and derivatives thereof isolated from Streptomyces chrestomyceticus BCC 24770, the construction of high-yield strains for albofungin production, and application of albofungin-based copolymer coatings to object or surfaces, particularly to inhibit fouling by marine organisms using hydrolysable and degradable antifouling coatings incorporated with albofungins.
    Type: Application
    Filed: July 21, 2022
    Publication date: March 23, 2023
    Inventors: Peiyuan QIAN, Weiyi SHE, Aifang CHENG, Wenkang YE, Ruojun WANG, Jinping CHENG, Chunfeng MA
  • ALBOFUNGIN AND ITS DERIVATIVES SPECIFICALLY RECOGNIZE HIV-1 LTR-III G-QUADRUPLEX
    Publication number: 20230057842
    Abstract: The subject invention pertains to compositions comprising albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo. The subject invention further pertains to methods of treating a subject with HIV using albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo.
    Type: Application
    Filed: June 1, 2022
    Publication date: February 23, 2023
    Inventors: Peiyuan QIAN, Aifang CHENG, Changdong LIU, Wenkang YE, Guang ZHU
  • NOVEL COMPOUNDS AS POTENTIAL THERAPEUTIC AGENTS TARGETING VARIOUS NEURODEGENERATIVE DISEASES
    Publication number: 20220112180
    Abstract: The subject invention pertains to compositions and methods for treating neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), multiple sclerosis, epilepsy, stroke, alcohol withdrawal, progressive supranuclear palsy (PSP), Pick's disease (PiD), corticobasal degeneration (CBD), frontotemporal dementia or parkinsonism linked to chromosome 17 (FTDP-17). The methods of the subject invention further relate to methods of fermentation of bacterial cells and methods of tautomerization of the subject compounds.
    Type: Application
    Filed: September 15, 2021
    Publication date: April 14, 2022
    Inventors: Pei-Yuan QIAN, Aifang CHENG, Changdong LIU, Wenkang YE, Guang ZHU