Abstract: The present invention relates to methods for delivering at least one agent unto or into a biological sample or a biological subject. The methods comprise a step of contacting the biological sample or subject with a payload-carrying nanostructure. The nanostructure can be a porous low density nanostructure.

Abstract: The present invention relates to a method of capturing, enriching, purifying, detecting or measuring a cell in a sample at a sub-nanogram level comprising providing a nanocomposition, contacting the sample with the nanocomposition to form a mixture solution and allowing the binding of the cell with the nanocomposition, applying a magnetic field to the mixture, and evaluating the presence of or absence of the cell. The nanocomposition is capable of capturing or enriching an analyte at a sub-nanogram level, and comprise a nanostructure operably linked to an analyte-capturing member.

Abstract: The present invention relates to a method of capturing, enriching, purifying, detecting or measuring a cell in a sample at a sub-nanogram level comprising providing a nanocomposition, contacting the sample with the nanocomposition to form a mixture solution and allowing the binding of the cell with the nanocomposition, applying a magnetic field to the mixture, and evaluating the presence of or absence of the cell. The nanocomposition is capable of capturing or enriching an analyte at a sub-nanogram level, and comprise a nanostructure operably linked to an analyte-capturing member.

Abstract: The present invention relates to a nanocomposition capable of capturing or enriching an analyte at a sub-nanogram level and methods thereof. The nanocomposition can comprise a nanostructure operably linked to an analyte-capturing member.

Abstract: The present disclosure provides compositions and methods useful for molecular and cellular separation, detection and quantification. The compositions provided herein comprise a nanostructure having magnetic property operably linked to an analyte-binding member.

Abstract: A uniform cluster of nanocompositions suspended in a liquid media is provided. Methods of making such nanocompositions, and uses of such nanocompositions are also provided. The nanocompositions can be used for nucleic acid extraction and diagnostic assays, for immunoassays, for cell separation, identification and modulation, for controlled functional molecule protection and release, for assays used in the clinic (companion diagnostics) or in the therapeutic development process (drug target validation), and in a system for transcatheter arterial chemoembolization, and demonstrate superior performance due to the uniform property or monodispersity.

Abstract: The present invention relates to nanostructures having low-density and porous coatings that surround or are associated with at least one core nanoparticles. The structures are capable of carrying or associating with at least one payload within or on the surface of the nanostructures so that the structures can be used in applications such as medical diagnosis or therapeutic treatment.

Abstract: The present invention relates to compositions comprising a porous nanostructure of a known characteristics and a fragment of nucleic acid having a known sequence. Methods of use of the compositions were also provided, for example in DNA amplification, detection, and DNA sequencing.

Abstract: A magnetic rack includes a bottom plate; a top plate mounted onto the bottom plate, the top plate having therein a first plurality of tube holes for retaining one or more tubes, each tube hole having an opening and a supporting wall extending from the opening between the top plate and the bottom plate; and a second plurality of magnetic assemblies distributed between at least a portion of the first plurality of tube holes, each magnetic assembly being configured to produce a magnetic field in one or more tube holes adjacent thereto.

Abstract: A magnetic rack includes a bottom plate; a top plate mounted onto the bottom plate, the top plate having therein a first plurality of tube holes for retaining one or more tubes, each tube hole having an opening and a supporting wall extending from the opening between the top plate and the bottom plate; and a second plurality of magnetic assemblies distributed between at least a portion of the first plurality of tube holes, each magnetic assembly being configured to produce a magnetic field in one or more tube holes adjacent thereto.

Abstract: A nanocomposition for modulating cell behaviors and methods of uses thereof. The nanocomposition comprises a nanostructure comprising at least one nanoparticle and at least one cell-modulating agent operably linked to the nanostructure. The cell-modulating agent can interact with a molecule on the surface of a cell, wherein the interaction between the cell-modulating agent and the molecule modulates a behavior of the cell, or purify and concentrate a cell population.

Abstract: Embodiments of the present disclosure provide for nanoprobes, methods of imaging, methods of imaging a target, methods of making nanoprobes, and the like.

Abstract: Embodiments of the present disclosure provide for nanoprobes, methods of imaging, methods of imaging a target, methods of making nanoprobes, and the like.

Abstract: The present application provides a magnetic rack for separating magnetic particles from a non-magnetic medium. The magnetic rack comprises a supporting housing having a top side, a bottom side, two opposite lengthwise sides, and a cavity, wherein at least one magnet is disposed in the cavity, each lengthwise side is attached with a receiving member, and the top side has at least two sockets. The magnetic rack further comprises a pair of supporting walls, wherein each supporting wall has a fixing member introduced onto or into the receiving member to tightly connect the supporting housing with the pair of supporting walls. With the coupling of the receiving member and the fixing member, the supporting wall and the supporting housing can be tightly connected together, therefore the shake of the magnetic rack or the sample vials inserted in the magnetic rack can be significantly avoided. In this way, the magnetic particles can be effectively separated from a non-magnetic medium in the sample vial.

Abstract: A kit comprising a nanostructure comprising at least one core nanoparticle, and a silanization coating on the surface of the core nanoparticle, and a binding buffer comprising a plurality of ingredients at concentration suitable to adjust the concentration of the plurality of ingredients in a solution containing at least one nucleic acid to concentration suitable for binding the nucleic acid through non-hybridization interaction to the nanostructure. A method of using the kit for reversibly binding nucleic acids through non-hybridization based interaction to a nanostructure is also provided.

Abstract: The present invention relates to a nanocomposition capable of capturing or enriching an analyte at a sub-nanogram level and methods thereof. The nanocomposition can comprise a nanostructure operably linked to an analyte-capturing member.

Abstract: The present invention relates to nanostructures having low-density and porous coatings that surround or are associated with at least one core nanoparticles. The structures are capable of carrying or associating with at least one payload within or on the surface of the nanostructures so that the structures can be used in applications such as medical diagnosis or therapeutic treatment.

Abstract: The present disclosure provides compositions and methods useful for molecular and cellular separation, detection and quantification. The compositions provided herein comprise a nanostructure having magnetic property operably linked to an analyte-binding member.

Abstract: The present invention relates to methods for delivering at least one agent unto or into a biological sample or a biological subject. The methods comprise a step of contacting the biological sample or subject with a payload-carrying nanostructure. The nanostructure can be a porous low density nanostructure.

Abstract: The present invention relates to compositions comprising a porous nanostructure of a known characteristics and a fragment of nucleic acid having a known sequence. Methods of use of the compositions were also provided, for example in DNA amplification, detection, and DNA sequencing.