Patents by Inventor Aihua Nie

Aihua Nie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of substituted tartaric acid and usage for preparing beta-secretase inhibitors
    Patent number: 8268884
    Abstract: The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of ?-amyloid peptide.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: September 18, 2012
    Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
    Inventors: Song Li, Guochao Liao, Junhai Xiao, Aihua Nie, Lili Wang, Wu Zhong, Zhibing Zheng
  • DERIVATIVES OF SUBSTITUTED TARTARIC ACID AND USAGE FOR PREPARING BETA-SECRETASE INHIBITORS
    Publication number: 20100331345
    Abstract: The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of ?-amyloid peptide.
    Type: Application
    Filed: February 5, 2007
    Publication date: December 30, 2010
    Inventors: Song Li, Guochao Liao, Junhai Xiao, Aihua Nie, Lili Wang, Wu Zhong, Zhibing Zheng
  • Substituted 6-membered N-heterocyclic compounds and method for their use as neurological regulator
    Patent number: 7304057
    Abstract: This invention relates to substituted 6-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R1, R2, X, Y, and Z are as defined in the description; their preparation methods, compositions comprising the same, and their use as inhibitors of FK560 binding proteases activity for treating and preventing neurodegenerative diseases and other nerve disorders associated with nerve injuries or other related diseases
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: December 4, 2007
    Assignee: Institute of Pharmacology and Toxicology Accademy of Military Medical Sciences P.L.A. China
    Inventors: Song Li, Aihua Nie, Beifen Shen, Lili Wang, Wuhong Pei, Junhai Xiao, Songcheng Yang, Liuhong Yun, Hongying Liu, Cuiling Shu, Hongxia Wang, Zihe Rao
  • Substituted 6−membered n−heterocyclic compounds and their uses as neurological regulator
    Publication number: 20050130958
    Abstract: This invention relates to substituted 6-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R1, R2, X, Y, and Z are as defined in the description; their preparation methods, compositions comprising the same, and their use as inhibitors of FK560 binding proteases activity for treating and preventing neurodegenerative diseases and other nerve disorders associated with nerve injuries or other related diseases.
    Type: Application
    Filed: December 5, 2002
    Publication date: June 16, 2005
    Inventors: Song Li, Aihua Nie, Beifen Shen, Lili Wang, Wuhong Pei, Junhai Xiao, Songcheng Yang, Liuhong Yun, Hongying Liu, Cuiling Shu, Hongxia Wang, Zihe Rao