Abstract: The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues.

Abstract: The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues.

Abstract: A magnesium alloy comprising up to about six weight percent zinc and up to about one weight percent cerium may be hot worked to produce an intermediate or final alloy workpiece that exhibits enhanced ductility and strength at room temperature. The addition of zinc and a small amount of cerium may affect the magnesium alloy by increasing strength and ductility, and improving the work hardening behavior.

Abstract: A process for dried fruit preparation, which process comprises treating fruit with polygalacturonase before drying step. Polygalacturonase can be further used in combination with pectinesterase, pectin lyase, pectate lyase, xyloglucanase, beta-glucanase, amylase and lipase.

Abstract: A plasma chamber is constructed to have a chamber body defining therein a plurality of process stations. A plurality of rotating substrate holders are each situated in one of the process stations and a plurality of in-situ plasma generation regions are each provided above one of the substrate holders. A plurality of quasi-remote plasma generation regions are each provided above a corresponding in-situ plasma generation region and being in gaseous communication with the corresponding in-situ plasma generation region. An RF energy source is coupled to each of the quasi-remote plasma generation regions.

Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

Abstract: The disclosure discloses a method for handover based on a radio resource allocation database. The method includes that the radio resource allocation database is constructed and dynamically maintained; after receiving a handover request from a User Equipment (UE), a Base Station (BS) determines in the database a Radio Access Technology (RAT) and the corresponding carrier frequency resources suitable for a current communication condition of the UE for the UE according to a handover reason in the handover request, and notifies the UE of information regarding the determined RAT and information regarding the corresponding carrier frequency resource; and the UE performs QoS verification on the RAT and the corresponding carrier frequency resources notified by the BS, and switches to the corresponding carrier frequency with the RAT notified by the BS when the QoS on the RAT and the corresponding carrier frequency resources is superior to that of current communication.

Abstract: The invention relates to a method for setting a CRBT, including: initiating a call to a called terminal and receiving a CRBT sent from a CBC, by a calling terminal in a communication network; during the process of playing the CRBT or the communication process or after the call is ended, authenticating the calling terminal by the communication network in response to a CRBT setting request message sent by the calling terminal or the called terminal actively or upon an inquiry, so as to judge whether the calling terminal activated a CRBT service; if it is judged that the calling terminal has not activated a CRBT service, sending, by the communication network, a CRBT service activation message to the calling terminal to instruct the calling terminal to subscribe the CRBT service, and then subscribing, by the calling terminal, the CRBT service through a response to the message; and if it is judged the calling terminal already activated the CRBT service, or the CRBT service is activated by the calling terminal resp

Abstract: A method of bonding a metal to a substrate involves forming an oxide layer on a surface of the substrate, and in a molten state, over-casting the metal on the substrate surface. The over-casting drives a reaction at an interface between the over-cast metal and the oxide layer to form another oxide. The other oxide binds the metal to the substrate surface upon solidification of the over-cast metal.

Abstract: This invention relates to phenyl thiazole I and its therapeutic and prophylactic uses, wherein the variables Rz, Q, J, R1, R3, R5, R6, and R7 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.

Abstract: A process is disclosed that includes brominating a C2, C3, C4, C5 or C6 alkane with elemental bromine to form a bromo-alkane. The bromo-alkane is reacted to form a C2, C3, C4, C5 or C6 alkene and HBr. The HBr is oxidized to form elemental bromine.

Abstract: A non-oriented electrical steel has relative high magnetic induction and high intensity without increasing manufacturing difficulty. The weight percentage of the compositions of the electrical steel are as follows: C?0.0040%, Si is 2.50% to 4.00%, Al is 0.20% to 0.80%, Cr is 1.0 to 8.0%, Ni is 0.5 to 5.0%, Mn?0.50%, P?0.30%, S?0.0020%, N?0.0030%, Ti?0.0030%, Nb?0.010%, V?0.010%, C+S+N+Ti?0.010%, and a balance substantially being Fe and inevitable impurities.

Abstract: A method of bonding a metal to a substrate involves forming a plurality of nano-features in a surface of the substrate, where each nano-feature is chosen from a nano-pore and/or a nano-crevice. In a molten state, the metal is over-cast onto the substrate surface, and penetrates the nano-features. Upon cooling, the metal is solidified inside the nano-features, where the solidification of the metal forms a mechanical interlock between the over-cast metal and the substrate.

Abstract: A manufacture process of non-oriented silicon steel with high magnetic induction includes smelting and casting steel having a chemical composition by weight percent: Si 0.1˜1%, Al 0.005˜1.0%, C?0.004%, Mn=0.10˜1.50%, P?0.2%, S?0.005%, N?0.002, Nb+V+Ti?0.006%, and the rest is Fe. The steel is cast into a billet, which is heated and hot-rolled to 1150˜1200° C. into a plate at a finish-rolling temperature 830˜900° C. The plate is cooled to a temperature ?570° C. and cold-roll flattened at compression ratio 2˜5%. The flattened plate is normalized at temperature not below 950° C. for 30˜180s, and then pickled and cold-rolled into a sheet with thickness of the finished product. The sheet is finish-annealed quickly heating the sheet to 800˜1000° C. at temperature rise rate ?100° C./s, soaking the heated sheet for 5˜60s at the temperature, and then slowly cooling the sheet to 600˜750° C.

Abstract: A pricing optimization system can solve a constrained optimization problem by generating one or more prices for one or more items that satisfy a maximum number of prioritized constraints. The one or more generated prices can be one or more prices that represent a minimal deviation between the generated one or more prices and one or more original prices for the one or more items. By satisfying a maximum number of prioritized constraints, and by minimizing a deviation from the one or more original prices for the one or more items, the generated one or more prices are one or more optimal prices.

Abstract: The present invention relates to an ultrasound treatment clamp. The ultrasound treatment clamp comprises ultrasound therapy applicators and handles connected to the ultrasound therapy applicators. The handles are clamp-shaped. The two ultrasound therapy applicators with their central axes overlapping each other are mounted face to face on the two clamps of the clamp-shaped handles respectively. A parallel moving mechanism for keeping the two ultrasound therapy applicators in parallel when moving along with clamps is connected between the two clamps. The present invention has a compact structure, a convenient operation, a low treatment cost, a capability of quickly causing a coagulative necrosis of the diseased part. Furthermore, the present invention has an abroad use in treating many kinds of diseases.

Abstract: The invention provides a method and a device for confirming a downlink inner loop power control mode by a Node B in an idle mode and in a CELL_FACH state. The method includes that: when the Node B detects that there is User Equipment (UE) using an E-DCH in the idle mode or in the CELL_FACH state, confirming to use a mode 0 to receive Transmit Power Control (TPC) bit information sent on a Dedicated Physical Control Channel (DPCCH) by the UE, and performing downlink inner loop power control on a Fractional Dedicated Physical Channel (F-DPCH). The method and device provided in the invention enable the inner loop power control mode for the F-DPCH made by the Node B to be consistent with the TPC bit information mode fed back by the UE, and enable the F-DPCH to use proper transmit power to transmit.

Abstract: The present invention discloses a method and system for coordinated scheduling based on cell priority, which is applied to the system using coordinated multiple point (CoMP) transmission technology. The method includes: performing priority sequencing on each coordinated cell according to the historical and/or current information of each coordinated cell and finishing scheduling of each coordinated cell in an order according to priority from high to low. By adopting the coordinated scheduling scheme in the present invention, the network can be made in a reasonable working status, and then, the performance of the entire system can be improved.

Abstract: The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of ?-amyloid peptide.

Abstract: A pricing optimization system can solve a constrained optimization problem by generating one or more prices for one or more items that satisfy a maximum number of prioritized constraints. The one or more generated prices can be one or more prices that represent a minimal deviation between the generated one or more prices and one or more original prices for the one or more items. By satisfying a maximum number of prioritized constraints, and by minimizing a deviation from the one or more original prices for the one or more items, the generated one or more prices are one or more optimal prices.