Abstract: The present invention relates to a pharmaceutical composition comprising, as an active ingredient, a peptide represented by the following formula (I): MTS-X-NLS  (I) wherein MTS represents a membrane-transfer amino acid sequence; X represents a direct bond or a linker sequence; and NLS represents a nuclear localization amino acid sequence, or a pharmaceutically acceptable salt thereof, particularly, a pharmaceutical composition having food and water intake inhibitory effects, and accompanying weight-reducing and obesity-inhibiting effects.

Abstract: A bearing seal for earth boring bits is disclosed. A supporting ring is located in a groove formed in the earth boring bit. An annular cavity between the outer circumference of the supporting ring and the bottom of the groove is connected with the outside. An O-ring made of rubber is provided in an annular space defined by the sidewalls of the groove, the inner circumference of the supporting ring and the cylindrical surface of the bearing shaft of the head section to form a seal comprising a radial and axial seal. Compressive deformation of the O-ring does not depend on the eccentric rotation of the cone. Therefore, the working life of the seal is increased and the compressive deformation is decreased, thus facilitating use at high rotating speeds.