Patents by Inventor Aik Choon Tan

Aik Choon Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MicroRNA Biomarkers for Diagnosing Parkinson's Disease
    Publication number: 20140302068
    Abstract: The identification, development and validation of plasma-based circulating microRNA (miRNAs) biomarkers useful in determining if a subject has Parkinson's disease (PD), is at increased risk of developing PD, or has PD that is progressing or is in remission are presented.
    Type: Application
    Filed: September 10, 2012
    Publication date: October 9, 2014
    Applicants: The Regents of the University of Colorado, Van Andel Research Institute
    Inventors: Sok Kean Khoo, Aik-Choon Tan
  • BIOLOGICAL MARKERS PREDICTIVE OF ANTI-CANCER RESPONSE TO INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR KINASE INHIBITORS
    Publication number: 20120201832
    Abstract: The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell expresses certain sensitivity or resistance biomarkers, or genomic classifiers. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate this methodology are also provided.
    Type: Application
    Filed: April 23, 2012
    Publication date: August 9, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Sue Gail ECKHARDT, Todd Michael PITTS, Aik Choon TAN
  • Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
    Patent number: 8163509
    Abstract: The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell expresses certain sensitivity or resistance biomarkers, or genomic classifiers. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate this methodology are also provided.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: April 24, 2012
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Sue Gail Eckhardt, Todd Michael Pitts, Aik Choon Tan
  • BIOLOGICAL MARKERS PREDICTIVE OF ANTI-CANCER RESPONSE TO INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR KINASE INHIBITORS
    Publication number: 20100240665
    Abstract: The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell expresses certain sensitivity or resistance biomarkers, or genomic classifiers. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate this methodology are also provided.
    Type: Application
    Filed: October 20, 2009
    Publication date: September 23, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Sue Gail ECKHARDT, Todd Michael PITTS, Aik Choon TAN
  • METHODS TO CORRECT GENE SET EXPRESSION PROFILES TO DRUG SENSITIVITY
    Publication number: 20090221522
    Abstract: The present invention comprises a treatment approach based on gene set-expression signatures that systematically connects a sample to a profile from a reference database to extrapolate the most effective therapeutic agent. Further disclosed are methods to optimize combination treatments.
    Type: Application
    Filed: February 17, 2009
    Publication date: September 3, 2009
    Applicant: The Johns Hopkins University
    Inventors: Manuel Hidalgo, Antonio Jimeno, Aik Choon Tan