Patents by Inventor Aikun Wang

Aikun Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intracellular protein delivery
    Patent number: 10131888
    Abstract: A secretion signal peptide sequence (SP) in combination with a cleavage inhibition sequence (CIS) fused to a structural gene sequence in a recombinant expression system can be used to express a full length protein with an SP in a cell. Such a fusion protein may be purified to homogeneity from a membrane fraction of the cell. The SP in combination with the CIS is a protein transduction domain that exhibits superior intracellular protein transduction efficiency when the SP precedes the CIS in a N to C-terminus direction.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: November 20, 2018
    Assignee: IPROGEN BIOTECH INC.
    Inventors: Keun Ho Lee, Leo Yen-Cheng Lin, Aikun Wang
  • INTRACELLULAR PROTEIN DELIVERY
    Publication number: 20180298359
    Abstract: A secretion signal peptide sequence (SP) in combination with a cleavage inhibition sequence (CIS) fused to a structural gene sequence in a recombinant expression system can be used to express a full length protein with an SP in a cell. Such a fusion protein may be purified to homogeneity from a membrane fraction of the cell. The SP in combination with the CIS is a protein transduction domain that exhibits superior intracellular protein transduction efficiency when the SP precedes the CIS in a N to C-terminus direction.
    Type: Application
    Filed: May 3, 2018
    Publication date: October 18, 2018
    Inventors: Keun Ho Lee, Leo Yen-Cheng Lin, Aikun Wang
  • Intracellular protein delivery
    Patent number: 9994829
    Abstract: A secretion signal peptide sequence (SP) in combination with a cleavage inhibition sequence (CIS) fused to a structural gene sequence in a recombinant expression system can be used to express a full length protein with an SP in a cell. Such a fusion protein may be purified to homogeneity from a membrane fraction of the cell. The SP in combination with the CIS is a protein transduction domain that exhibits superior intracellular protein transduction efficiency when the SP precedes the CIS in a N to C-terminus direction.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: June 12, 2018
    Assignee: IPROGEN BIOTECH, INC.
    Inventors: Keun Ho Lee, Leo Yen-Cheng Lin, Aikun Wang
  • INTRACELLULAR PROTEIN DELIVERY
    Publication number: 20150191710
    Abstract: A secretion signal peptide sequence (SP) in combination with a cleavage inhibition sequence (CIS) fused to a structural gene sequence in a recombinant expression system can be used to express a full length protein with an SP in a cell. Such a fusion protein may be purified to homogeneity from a membrane fraction of the cell. The SP in combination with the CIS is a protein transduction domain that exhibits superior intracellular protein transduction efficiency when the SP precedes the CIS in a N to C-terminus direction.
    Type: Application
    Filed: July 2, 2013
    Publication date: July 9, 2015
    Inventors: Keun Ho Lee, Leo Yen-Cheng Lin, Aikun Wang