Patents by Inventor Aileen Bouffard

Aileen Bouffard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal agents
    Patent number: 7863465
    Abstract: The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-?-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: January 4, 2011
    Assignees: Merck Sharp & Dohme Corp., Scynexis, Inc.
    Inventors: James M. Balkovec, Frances Aileen Bouffard, Bruno Tse, James Dropinski, Dongfang Meng, Mark L. Greenlee, Michael Peel, Weiming Fan, Ahmed Mamai, Hao Liu, Keqaing Li
  • Therapeutic compounds for treating dyslipidemic conditions
    Patent number: 6908934
    Abstract: Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia ?and (b) Formula Ib are novel LXR agonists and are useful in the treatment of dyslipidemic conditions particularly depressed levels of HDL cholesterol.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: June 21, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Alan D. Adams, Aileen Bouffard, James F. Dropinski, Clare E. Gutteridge, A. Brian Jones, Weiguo Lui, John George Ondeyka, Ali Shiafee, Sheo Bux Singh
  • Therapeutic compounds for treating dyslipidemic conditions
    Publication number: 20030125357
    Abstract: Compounds of Formula I 1
    Type: Application
    Filed: May 30, 2002
    Publication date: July 3, 2003
    Inventors: Alan D. Adams, Aileen Bouffard, James F. Dropinski, Clare E. Gutteridge, A. Brian Jones, Weiguo Lui, John George Ondeyka, Ali Shiafee, Sheo Bux Singh
  • Cyclohexapeptidyl amine compounds
    Patent number: 6268338
    Abstract: Cyclohexapeptidyl amine compounds are disclosed of the formula: or its acid addition salt, wherein: R1 is H or OH; R2 is H or OH; R3 is QCnH2nNRVRVI, QCnH2nNRVRVIRVII+Y−, or Q(CH2)1-3CRVIIIRIXNHRX.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: July 31, 2001
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Frances Aileen Bouffard, James F. Dropinski, Robert A. Zambias
  • Cyclohexapeptidyl bisamine compounds
    Patent number: 6030944
    Abstract: Certain bisamine compounds which have a cyclohexapeptidyl nucleus and which are found to have antibiotic activity with physical properties suitable for direct use in therapeutic compositions are described. A novel process for their preparation is also described.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: February 29, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Frances Aileen Bouffard, James F. Dropinski, Robert A. Zambias
  • 1-?4-hydroxy-5-aminoethyloxy-N.sup.2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3- hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof
    Patent number: 5914313
    Abstract: A compound having the formula ##STR1## in which R.sub.1 is an aminoalkyl group and ##STR2## is an acyl group and salts thereof having high antibiotic activity and being substantially free of lytic activity are described.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: June 22, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Frances Aileen Bouffard, James F. Dropinski
  • Aza cyclohexapeptide compounds
    Patent number: 5792746
    Abstract: Ceretain aza cyclohexapeptide compounds have been found to have superior antibiotic properties. Novel processes for their preparation are also described.
    Type: Grant
    Filed: October 28, 1996
    Date of Patent: August 11, 1998
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Frances Aileen Bouffard, Regina M. Black
  • Cyclohexapeptidyl aminoalkyl ethers
    Patent number: 5741775
    Abstract: There are disclosed compounds of the general formula ##STR1## wherein all substituents are defined herein. The compounds are useful as antibiotic and antifungal agents.
    Type: Grant
    Filed: June 13, 1995
    Date of Patent: April 21, 1998
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, James F. Dropinski, Frances Aileen Bouffard
  • Process for the stereocontrolled silyloxyethylation of azetidinones
    Patent number: 4816578
    Abstract: A stereospecific process for preparing 3-trans-R-trisubstituted silyloxyethyl substituted azetidinones useful as intermediates for preparing penems and carbapenems is provided wherein a 3-unsubstituted azetidinone is treated with a strong base and a trisubstituted silylmethyl ketone to form 3-trans-S-[1-trisubstituted silyl-1-hydroxy]ethylazetidinone followed by rearrangement of this resulting carbinol by treatment with an alkali metal alkoxide and a proton source.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: March 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: F. Aileen Bouffard, Thomas N. Salzmann
  • Substituted azetidiones
    Patent number: 4348320
    Abstract: Disclosed are substituted azetidinones (1) which are useful in the preparation of 1-carba-2-penem-3-carboxylic acids (I): ##STR1## wherein R is hydrogen or a blocking group and R.sup.1, R.sup.2 and R.sup.3 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. Such 1-carba-2-penem-3-carboxylic acids and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics.
    Type: Grant
    Filed: August 20, 1980
    Date of Patent: September 7, 1982
    Assignee: Merck & Co., Inc.
    Inventors: F. Aileen Bouffard, Burton G. Christensen, David B. R. Johnston
  • Schiff's base derivatives of thienamycin
    Patent number: 4172144
    Abstract: Disclosed are Schiff's base derivatives of the antibiotic thienamycin, which has the following structure: ##STR1## Such compounds and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives, and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: May 19, 1978
    Date of Patent: October 23, 1979
    Assignee: Merck & Co., Inc.
    Inventors: F. Aileen Bouffard, Burton G. Christensen, Nathan G. Steinberg