Patents by Inventor Aileen Zhou
Aileen Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220348657Abstract: Provided herein are components (e.g., cells and soluble proteins), systems, and methods for assessing the biological activity of soluble proteins comprising an Fc domain and a CD28-binding domain (e.g., CD80 extracellular domain Fc fusion proteins).Type: ApplicationFiled: April 17, 2020Publication date: November 3, 2022Inventors: Luis BORGES, Artur KARASYOV, Zheng MENG, Shawn RUSSELL, Nathan SALLEE, Hongbing ZHANG, Aileen ZHOU
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Publication number: 20140170145Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.Type: ApplicationFiled: October 8, 2013Publication date: June 19, 2014Applicant: FIVE PRIME THERAPEUTICS, INC.Inventors: Dirk Behrens, Elizabeth Bosch, Stephen K. Doberstein, Robert Forgan Halenbeck, Kevin Hestir, Min Mei Huang, Ernestine Lee, Haishan Lin, Thomas Linnemann, Shannon Marshall, Justin Wong, Ge Wu, Aileen Zhou, Cindy Leo, Lewis T. Williams
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Patent number: 8575312Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.Type: GrantFiled: April 13, 2012Date of Patent: November 5, 2013Assignee: Five Prime Therapeutics, Inc.Inventors: Dirk Behrens, Elizabeth Bosch, Stephen K. Doberstein, Robert Forgan Halenbeck, Kevin Hestir, Min Mei Huang, Ernestine Lee, Haishan Lin, Thomas Linnemann, Shannon Marshall, Justin G. P. Wong, Ge Wu, Aileen Zhou, Cindy Leo, Lewis T. Williams
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Patent number: 8327351Abstract: Methods and apparatus for an application modification framework used in an integrated technology platform are shown, which allows hot deployment of modifications, including a modification component, a hot deployment component, and a package manager component. The framework provides various editors to allow a developer of the base application or a custom client application to edit files and features associated with the application. Managers are provided to control each of the editors and for maintenance of historical information to allow auditing and modification monitoring. Hot deployment controls the ability of the user to implement modifications and changes, wherein changes are identified as to origin and purpose, allowing smart debug to identify if error(s) occurred during custom modification, base modification or otherwise.Type: GrantFiled: April 30, 2009Date of Patent: December 4, 2012Assignee: SAP AGInventors: Gaetano Paladino, Al J. Marcella, Kamal Nash, Aileen Zhou
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Publication number: 20120258071Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.Type: ApplicationFiled: April 13, 2012Publication date: October 11, 2012Inventors: Dirk Behrens, Elizabeth Bosch, Stephen K. Doberstein, Robert Forgan Halenbeck, Kevin Hestir, Min Mei Huang, Ernestine Lee, Haishan Lin, Thomas Linnemann, Shannon Marshall, Justin G. P. Wong, Ge Wu, Aileen Zhou, Cindy Leo, Lewis T. Williams
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Patent number: 8178109Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.Type: GrantFiled: February 12, 2009Date of Patent: May 15, 2012Assignee: Five Prime Therapeutics, Inc.Inventors: Dirk Behrens, Elizabeth Bosch, Stephen K. Doberstein, Robert Forgan Halenbeck, Kevin Hestir, Min Mei Huang, Ernestine Lee, Haishan Lin, Thomas Linnemann, Shannon Marshall, Justin G. P. Wong, Ge Wu, Aileen Zhou, Cindy Leo, Lewis T. Williams
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Patent number: 7901621Abstract: Methods for removing a residue of one or more biological materials deposited on the walls of a microfluidic conduit in microscale devices are provided. In an example of the methods, one or more colloidal-size particles, such as colloidal silica particles, are flowed in a fluid within the microfluidic conduit having residues of materials previously deposited on the walls thereof to adsorb to the materials and to remove such deposits from the walls of the microfluidic conduit.Type: GrantFiled: July 2, 2007Date of Patent: March 8, 2011Assignee: Caliper Life Sciences, Inc.Inventors: Dean G. Hafeman, Aileen Zhou
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Publication number: 20110003384Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.Type: ApplicationFiled: February 12, 2009Publication date: January 6, 2011Inventors: Dirk BEHRENS, Elizabeth Bosch, Stephen K. Doberstein, Robert Forgan Halenbeck, Kevin Hestir, Min Mei Huang, Ernestine Lee, Haishan Lin, Thomas Linnemann, Shannon Marshall, Justin G. P. Wong, Ge Wu, Aileen Zhou, Cindy Leo, Lewis T. Williams
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Publication number: 20100281458Abstract: Methods and apparatus for an application modification framework used in an integrated technology platform are shown, which allows hot deployment of modifications, including a modification component, a hot deployment component, and a package manager component. The framework provides various editors to allow a developer of the base application or a custom client application to edit files and features associated with the application. Managers are provided to control each of the editors and for maintenance of historical information to allow auditing and modification monitoring. Hot deployment controls the ability of the user to implement modifications and changes, wherein changes are identified as to origin and purpose, allowing smart debug to identify if error(s) occurred during custom modification, base modification or otherwise.Type: ApplicationFiled: April 30, 2009Publication date: November 4, 2010Applicant: Business Objects, S.A.Inventors: Gaetano Paladino, Al J. Marcella, Kamal Nash, Aileen Zhou
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Publication number: 20070264277Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.Type: ApplicationFiled: July 21, 2005Publication date: November 15, 2007Inventors: Dirk Behrens, Elizabeth Bosch, Stephen Doberstein, Robert Halenbeck, Kevin Hestir, Min Huang, Ernestine Lee, Haishan Lin, Thomas Linnemann, Shannon Marshall, Justin Wong, Ge Wu, Aileen Zhou
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Publication number: 20070246076Abstract: Methods for reducing surface adsorption of biological materials to the walls of microfluidic conduits in microscale devices are provided. In an example of the methods, one or more colloidal-size particles, such as colloidal silica particles, are flowed in a fluid within the microfluidic conduit in the presence of one or more adherent biological materials (such as one or more proteins, cells, carbohydrates, nucleic acids, lipids and the like) to adsorb to the materials and prevent them from binding to the capillary walls of the microfluidic conduit. Other adsorption inhibition agents such as detergents and nonaqueous solvents can be used alone or in combination with colloidal particles to reduce surface adsorption in microfluidic conduits.Type: ApplicationFiled: July 2, 2007Publication date: October 25, 2007Applicant: Caliper Life Sciences, Inc.Inventors: Dean Hafeman, Aileen Zhou
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Patent number: 7252928Abstract: Methods for reducing surface adsorption of biological materials to the walls of microfluidic conduits in microscale devices are provided. In an example of the methods, one or more colloidal-size particles, such as colloidal silica particles, are flowed in a fluid within the microfluidic conduit in the presence of one or more adherent biological materials (such as one or more proteins, cells, carbohydrates, nucleic acids, lipids and the like) to adsorb to the materials and prevent them from binding to the capillary walls of the microfluidic conduit. Other adsorption inhibition agents such as detergents and nonaqueous solvents can be used alone or in combination with colloidal particles to reduce surface adsorption in microfluidic conduits.Type: GrantFiled: February 25, 2003Date of Patent: August 7, 2007Assignee: Caliper Life Sciences, Inc.Inventors: Dean G. Hafeman, Aileen Zhou
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Publication number: 20060219557Abstract: Methods and systems of monitoring reactions, e.g., assays, that filter out background signal from substrate, in detecting the product. The methods and systems controllably move detectable reaction product from a first location to a second location at which the product is detected while controllably moving potentially interfering substrate materials away from or not toward the second location. Controllable movement of the different species is accomplished through the controlled combination of bulk fluid flow and differential electrophoresis of substrate and product to move the product, but not the substrate past the detection region.Type: ApplicationFiled: April 25, 2006Publication date: October 5, 2006Applicant: Caliper Life Sciences, Inc.Inventors: Theo Nikiforov, Aileen Zhou
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Patent number: 7060171Abstract: Methods and systems of monitoring reactions, e.g., assays, that filter out background signal from substrate, in detecting the product. The methods and systems controllably move detectable reaction product from a first location to a second location at which the product is detected while controllably moving potentially interfering substrate materials away from or not toward the second location. Controllable movement of the different species is accomplished through the controlled combination of bulk fluid flow and differential electrophoresis of substrate and product to move the product, but not the substrate past the detection region.Type: GrantFiled: July 24, 2002Date of Patent: June 13, 2006Assignee: Caliper Life Sciences, Inc.Inventors: Theo T. Nikiforov, Aileen Zhou