Patents by Inventor Ailen Sanchez

Ailen Sanchez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Refolding of recombinant proteins
    Patent number: 9994612
    Abstract: Processes are provided for recovering and purifying refolded recombinant proteins produced in heterologous host cells, which includes the step of refolding the protein in a high pH buffer.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: June 12, 2018
    Assignee: Genentech, Inc.
    Inventors: Shelly Pizarro, Ailen Sanchez, Charles H. Schmelzer
  • REFOLDING OF RECOMBINANT PROTEINS
    Publication number: 20160137690
    Abstract: Processes are provided for recovering and purifying refolded recombinant proteins produced in heterologous host cells, which includes the step of refolding the protein in a high pH buffer.
    Type: Application
    Filed: October 26, 2015
    Publication date: May 19, 2016
    Inventors: Shelly PIZARRO, Ailen SANCHEZ, Charles H. SCHMELZER
  • Refolding of recombinant proteins
    Patent number: 9200030
    Abstract: Processes are provided for recovering and purifying refolded recombinant proteins produced in heterologous host cells, which includes the step of refolding the protein in a high pH buffer.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: December 1, 2015
    Assignee: Genentech, Inc.
    Inventors: Shelly Pizarro, Ailen Sanchez, Charles H. Schmelzer
  • Increasing bacterial succinate productivity
    Patent number: 8795991
    Abstract: Improved bacteria for making succinate and other 4 carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and overexpress In one embodiment, the bacteria are ?adhE?ldhA?iclR?ack-pta plus PYC+ and NAD+-dependant FDH+.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: August 5, 2014
    Assignee: William Marsh Rice University
    Inventors: Ka-Yiu San, George Bennett, Grant Balzer, Jiangfeng Zhu, Chandresh Thakker, Ailen Sanchez
  • Refolding of Recombinant Proteins
    Publication number: 20110294990
    Abstract: Processes are provided for recovering and purifying refolded recombinant proteins produced in heterologous host cells, which includes the step of refolding the protein in a high pH buffer.
    Type: Application
    Filed: August 2, 2011
    Publication date: December 1, 2011
    Applicant: GENENTECH, INC.
    Inventors: SHELLY PIZARRO, AILEN SANCHEZ, CHARLES H. SCHMELZER
  • High molar succinate yield bacteria by increasing the intracellular NADH availability
    Patent number: 7927859
    Abstract: The invention relates to increasing the yield of succinate in bacteria by increasing the intracellular availability of cofactors such as NADH.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: April 19, 2011
    Assignee: Rice University
    Inventors: Ka-Yiu San, George N. Bennett, Ailen Sánchez
  • Mutant strain with increased succinic acid production
    Patent number: 7790416
    Abstract: The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: September 7, 2010
    Assignee: Rice University
    Inventors: Ka-Yiu San, George N. Bennett, Ailen Sanchez
  • Simultaneous anaerobic production of isoamyl acetate and succinic acid
    Patent number: 7569380
    Abstract: In vivo method of producing esters from acetyle coA, such as isoamyl acetate and succinate, has been developed by producing null mutants in pathways that use acetyl coA and by overexpressing products that use NADH and in order to maintain the proper redox balance between NADH and NAD+. The method is exemplified with null mutations in ldhA, adhE, ackA-pta and overexpression of pyruvate carboxylase and alcohol acetyltransferase. This strain produces higher levels of both isoamyl acetate and succinate.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: August 4, 2009
    Assignee: Rice University
    Inventors: Ka-Yiu San, Ailen Sanchez, George N. Bennett, Cheryl Renee Dittrich
  • Refolding of Recombinant Proteins
    Publication number: 20080125580
    Abstract: Processes are provided for recovering and purifying refolded recombinant proteins produced in heterologous host cells, which includes the step of refolding the protein in a high pH buffer.
    Type: Application
    Filed: July 13, 2007
    Publication date: May 29, 2008
    Applicant: Genentech, Inc.
    Inventors: Shelly Pizarro, Ailen Sanchez, Charles H. Schmelzer
  • Increasing intracellular NADPH availability in
    Patent number: 7326557
    Abstract: A method of increasing cellular NADPH levels by expressing one or more genes that encode a enzyme that causes the production of NADPH. The system can be combined with other enzymes that require NADPH, thus improving the overall production of the desired protein.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: February 5, 2008
    Assignee: Rice University
    Inventors: Ka-Yiu San, George N. Bennett, Ailen Sanchez
  • Mutant strain with increased succinic acid production
    Patent number: 7223567
    Abstract: The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions.
    Type: Grant
    Filed: August 29, 2005
    Date of Patent: May 29, 2007
    Assignee: Rice University
    Inventors: San Ka-Yiu, George N. Bennett, Ailen Sanchez
  • Simultaneous anaerobic production of isoamyl acetate and succinic acid
    Publication number: 20060141594
    Abstract: In vivo method of producing esters from acetyle coA, such as isoamyl acetate and succinate, has been developed by producing null mutants in pathways that use acetyl coA and by overexpressing products that use NADH and in order to maintain the proper redox balance between NADH and NAD+. The method is exemplified with null mutations in ldhA, adhE, ackA-pta and overexpression of pyruvate carboxylase and alcohol acetyltransferase. This strain produces higher levels of both isoamyl acetate and succinate.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 29, 2006
    Inventors: Ka-Yiu San, Ailen Sanchez, George Bennett, Cheryl Dittrich
  • High succinate producing bacteria
    Publication number: 20060073577
    Abstract: The invention relates to a hybrid succinate production system that has a high capacity to produce succinate under aerobic and anaerobic conditions. The metabolic engineering of a hybrid bacterial succinate production system that can function under both aerobic and anaerobic conditions makes the production process more efficient, and the process control and optimization less difficult.
    Type: Application
    Filed: September 16, 2005
    Publication date: April 6, 2006
    Inventors: San Ka-Yiu, George Bennett, Lin Henry, Ailen Sanchez
  • Mutant E. coli strain with increased succinic acid production
    Publication number: 20060046288
    Abstract: The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions.
    Type: Application
    Filed: August 29, 2005
    Publication date: March 2, 2006
    Inventors: San Ka-Yiu, George Bennett, Ailen Sanchez
  • Increasing intracellular NADPH availability in E. coli
    Publication number: 20050196866
    Abstract: A method of increasing cellular NADPH levels by expressing one or more genes that encode a enzyme that causes the production of NADPH. The system can be combined with other enzymes that require NADPH, thus improving the overall production of the desired protein.
    Type: Application
    Filed: November 12, 2004
    Publication date: September 8, 2005
    Applicant: Rice University
    Inventors: Ka-Yiu San, George Bennett, Ailen Sanchez
  • High molar succinate yield bacteria by increasing the intracellular NADH availability
    Publication number: 20050042736
    Abstract: The invention relates to increasing the yield of succinate in bacteria by increasing the intracellular availability of cofactors such as NADH.
    Type: Application
    Filed: August 20, 2004
    Publication date: February 24, 2005
    Inventors: Ka-Yiu San, George Bennett, Ailen Sanchez