Abstract: In some aspects the disclosure provides compositions and methods for promoting expression of functional Forkhead box G1 (FOXG1) protein in a subject. In some embodiments, the disclosure provides methods of treating a subject having FOXG1 deficiency.

Abstract: In some aspects the disclosure provides compositions and methods for promoting expression of functional Forkhead box G1 (FOXG1) protein in a subject. In some embodiments, the disclosure provides methods of treating a subject having FOXG1 deficiency.

Abstract: Aspects of the disclosure relate to compositions and methods for delivering a transgene (e.g., a transgene encoding one or more gene products) to a target cell. The disclosure is based, in part, on adeno-associated virus (AAV) capsid protein variants characterized by tropisms for certain cell types (e.g., neurons, lung cells muscle cells, bone cells, heart cells, etc.). In some embodiments, recombinant AAVs (rAAVs) comprising the capsid protein variants described herein exhibit enhanced lung tropism when compared to rAAVs having certain wild-type AAV capsid proteins (e.g., AAV5). Methods of delivering an rAAV comprising the AAV capsid protein variants are also described by the disclosure.

Abstract: In some aspects the disclosure provides compositions and methods for promoting expression of functional Forkhead box G1 (FOXG1) protein in a subject. In some embodiments, the disclosure provides methods of treating a subject having FOXG1 deficiency.

Abstract: Systems, methods, and other embodiments associated with handling secure interrupts between security zones are described. According to one embodiment, an apparatus includes a memory divided between a secure zone and a non-secure zone and storing a plurality of applications. The secure zone provides exclusive access to secure assets of the apparatus. A processor with an interface module configured to, in response to receiving an interrupt request from a requesting application that executes on the processor in the non-secure zone, tunnel the interrupt request into the secure zone of the processor. The non-secure zone and the secure zone are configured as operating environments of the processor with separate security controls. The processor includes a monitor module configured to issue the secure interrupt to a trusted application that is one of the plurality of applications in the secure zone, wherein the trusted application is registered to handle the secure interrupt.