Abstract: In some aspects the disclosure provides compositions and methods for promoting expression of functional Forkhead box G1 (FOXG1) protein in a subject. In some embodiments, the disclosure provides methods of treating a subject having FOXG1 deficiency.

Abstract: Systems, methods, and other embodiments associated with handling secure interrupts between security zones are described. According to one embodiment, an apparatus includes a memory divided between a secure zone and a non-secure zone and storing a plurality of applications. The secure zone provides exclusive access to secure assets of the apparatus. A processor with an interface module configured to, in response to receiving an interrupt request from a requesting application that executes on the processor in the non-secure zone, tunnel the interrupt request into the secure zone of the processor. The non-secure zone and the secure zone are configured as operating environments of the processor with separate security controls. The processor includes a monitor module configured to issue the secure interrupt to a trusted application that is one of the plurality of applications in the secure zone, wherein the trusted application is registered to handle the secure interrupt.