Patents by Inventor Aimee B. Angel

Aimee B. Angel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8246582
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and a needle with a bore extending along the length of the needle from a first end of the needle to a second end of the needle. The second end is substantially aligned to a plane parallel to a body surface of a biological body when the device is placed on the body surface. The device also includes an actuator which pumps the formulation through the bore of the needle between a target area of the body and the reservoir.
    Type: Grant
    Filed: April 29, 2008
    Date of Patent: August 21, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Patent number: 7651475
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and an array of needles which have bores in fluid communication with the reservoir to facilitate transporting the formulation to and from the reservoir through the needles. The device also includes a first actuator which drives the array of needles into the body, and a second actuator which pumps the formulation between the reservoir and the body through the needles. The first actuator is reversible to withdraw the needles from the body.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: January 26, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Patent number: 7645263
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, a needle with a bore through which the formulation is transported between the reservoir and a target area of a biological body, and an impedance sensor. The impedance sensor has an electrode positioned to measure the impedance of a portion of the target area between the needle and the electrode to indicate the depth of penetration of the needle into the target area.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: January 12, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter, Laura L. Proctor, James Tangorra
  • Publication number: 20080319392
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and an array of needles which have bores in fluid communication with the reservoir to facilitate transporting the formulation to and from the reservoir through the needles. The device also includes a first actuator which drives the array of needles into the body, and a second actuator which pumps the formulation between the reservoir and the body through the needles. The first actuator is reversible to withdraw the needles from the body.
    Type: Application
    Filed: January 11, 2008
    Publication date: December 25, 2008
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Publication number: 20080281273
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and a needle with a bore extending along the length of the needle from a first end of the needle to a second end of the needle. The second end is substantially aligned to a plane parallel to a body surface of a biological body when the device is placed on the body surface. The device also includes an actuator which pumps the formulation through the bore of the needle between a target area of the body and the reservoir.
    Type: Application
    Filed: April 29, 2008
    Publication date: November 13, 2008
    Applicant: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Patent number: 7429258
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and an array of needles which have bores in fluid communication with the reservoir to facilitate transporting the formulation to and from the reservoir through the needles. The device also includes a first actuator which drives the array of needles into the body, and a second actuator which pumps the formulation between the reservoir and the body through the needles. The first actuator is reversible to withdraw the needles from the body.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: September 30, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Patent number: 7425204
    Abstract: An injector includes a housing having a chamber for holding a liquid formulation of an active principle to be injected into a biological body and an output port in fluid communication with the chamber through which the liquid formulation is injected. A piston is positioned within the housing, and includes an end portion with substantially the same shape as the chamber. A magnetic force draws the piston and housing together to expel the liquid formulation out of the chamber through the output port.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: September 16, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Patent number: 7364568
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and a needle with a bore extending along the length of the needle from a first end of the needle to a second end of the needle. The second end is substantially aligned to a plane parallel to a body surface of a biological body when the device is placed on the body surface. The device also includes an actuator which pumps the formulation through the bore of the needle between a target area of the body and the reservoir.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: April 29, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Patent number: 7066922
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and one or more needles. Each needle has a bore through which the formulation is transported between the reservoir and a biological body, and has an end portion that is substantially aligned in a plane parallel to a surface of the biological body when the device is placed on the surface. The device also includes a vacuum generator which creates a suction to draw a portion of the surface beyond the plane of the end portions to enable the end portions to penetrate the portion of the surface as the needles are translated along an axis that is substantially parallel to the plane.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: June 27, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter, Peter Hansen
  • Patent number: 6939323
    Abstract: An injector includes a housing having a chamber for holding a liquid formulation of an active principle to be injected into a biological body and an output port in fluid communication with the chamber through which the liquid formulation is injected. A piston is positioned within the housing, and includes an end portion with substantially the same shape as the chamber. A magnetic force draws the piston and housing together to expel the liquid formulation out of the chamber through the output port.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: September 6, 2005
    Assignee: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Publication number: 20030139727
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and one or more needles. Each needle has a bore through which the formulation is transported between the reservoir and a biological body, and has an end portion that is substantially aligned in a plane parallel to a surface of the biological body when the device is placed on the surface. The device also includes a vacuum generator which creates a suction to draw a portion of the surface beyond the plane of the end portions to enable the end portions to penetrate the portion of the surface as the needles are translated along an axis that is substantially parallel to the plane.
    Type: Application
    Filed: October 21, 2002
    Publication date: July 24, 2003
    Applicant: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter, Peter Hansen
  • Publication number: 20030083641
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, a needle with a bore through which the formulation is transported between the reservoir and a target area of a biological body, and an impedance sensor. The impedance sensor has an electrode positioned to measure the impedance of a portion of the target area between the needle and the electrode to indicate the depth of penetration of the needle into the target area.
    Type: Application
    Filed: October 21, 2002
    Publication date: May 1, 2003
    Applicant: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter, Laura L. Proctor, James Tangorra
  • Publication number: 20030083611
    Abstract: An injector includes a housing having a chamber for holding a liquid formulation of an active principle to be injected into a biological body and an output port in fluid communication with the chamber through which the liquid formulation is injected. A piston is positioned within the housing, and includes an end portion with substantially the same shape as the chamber. A magnetic force draws the piston and housing together to expel the liquid formulation out of the chamber through the output port.
    Type: Application
    Filed: July 19, 2002
    Publication date: May 1, 2003
    Applicant: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Publication number: 20030083619
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and a needle with a bore extending along the length of the needle from a first end of the needle to a second end of the needle. The second end is substantially aligned to a plane parallel to a body surface of a biological body when the device is placed on the body surface. The device also includes an actuator which pumps the formulation through the bore of the needle between a target area of the body and the reservoir.
    Type: Application
    Filed: October 21, 2002
    Publication date: May 1, 2003
    Applicant: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Publication number: 20030083645
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and an array of needles which have bores in fluid communication with the reservoir to facilitate transporting the formulation to and from the reservoir through the needles. The device also includes a first actuator which drives the array of needles into the body, and a second actuator which pumps the formulation between the reservoir and the body through the needles. The first actuator is reversible to withdraw the needles from the body.
    Type: Application
    Filed: September 9, 2002
    Publication date: May 1, 2003
    Applicant: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter
  • Publication number: 20030083618
    Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, a needle with a bore through which the formulation is transported between the reservoir and a target area of a biological body, and an electrolytic actuator which pumps the formulation through the bore.
    Type: Application
    Filed: October 21, 2002
    Publication date: May 1, 2003
    Applicant: Massachusetts Institute of Technology
    Inventors: Aimee B. Angel, Ian W. Hunter, Peter Madden