Abstract: Aspects of the present disclosure relate to projecting control parameters of equipment associated with forming a wellbore, stimulating the wellbore, or producing fluid from the wellbore. A system includes the equipment and a computing device. The computing device is operable to project a control parameter value of the equipment using an equipment control process, and to receive confirmation that the projected control parameter value is within an allowable operating range. The computing device is also operable to adjust the equipment control process based on the confirmation, and to control the equipment to operate at the projected control parameter value. Further, the computing device is operable to receive real-time data associated with the forming of the wellbore, the stimulating of the wellbore, or the producing fluid from the wellbore. Furthermore, the computing device is operable to adjust the equipment control process based on the real-time data.

Abstract: The use of a modified reduced indium tin oxide to provide a security image wherein the modified reduced indium tin oxide is obtained by heating indium tin oxide in a reducing atmosphere at a temperature of from 300 to 500° C.; and contacting the reduced indium tin oxide with an organophosphorus compound.

Abstract: A drill bit subsystem can include a drill bit, a processor, and a non-transitory computer-readable medium for storing instructions and for being positioned downhole with the drill bit. The instructions of the non-transitory computer-readable medium can include a machine-teachable module and a control module that are executable by the processor. The machine-teachable module can receive depth data and rate of drill bit penetration from one or more sensors in a drilling operation, and determine an estimated lithology of a formation at which the drill bit subsystem is located. The control module can use the estimated lithology to determine an updated location of the drill bit subsystem, and control a direction of the drill bit using the updated location and a drill plan.

Abstract: Aspects of the present disclosure relate to projecting control parameters of equipment associated with forming a wellbore, stimulating the wellbore, or producing fluid from the wellbore. A system includes the equipment and a computing device. The computing device is operable to project a control parameter value of the equipment using an equipment control process, and to receive confirmation that the projected control parameter value is within an allowable operating range. The computing device is also operable to adjust the equipment control process based on the confirmation, and to control the equipment to operate at the projected control parameter value. Further, the computing device is operable to receive real-time data associated with the forming of the wellbore, the stimulating of the wellbore, or the producing fluid from the wellbore. Furthermore, the computing device is operable to adjust the equipment control process based on the real-time data.

Abstract: A drill bit subsystem can include a drill bit, a processor, and a non-transitory computer-readable medium for storing instructions and for being positioned downhole with the drill bit. The instructions of the non-transitory computer-readable medium can include a machine-teachable module and a control module that are executable by the processor. The machine-teachable module can receive depth data and rate of drill bit penetration from one or more sensors in a drilling operation, and determine an estimated lithology of a formation at which the drill bit subsystem is located. The control module can use the estimated lithology to determine an updated location of the drill bit subsystem, and control a direction of the drill bit using the updated location and a drill plan.

Abstract: Provided herein are double-stranded, chemically-modified oligonucleotide mimetics of miR-29 for use in treating ocular diseases or disorders associated with ocular fibrosis, and ocular fibrotic conditions.

Abstract: The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such as a T cell lymphoma in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for reducing or inhibiting the proliferation of malignant T cells by administering an oligonucleotide inhibitor of miR-155.

Abstract: The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates miR-92 function and/or activity.

Abstract: The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such as a T cell lymphoma in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for reducing or inhibiting the proliferation of malignant T cells by administering an oligonucleotide inhibitor of miR-155.

Abstract: The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates miR-92 function and/or activity.

Abstract: The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such as a T cell lymphoma in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for reducing or inhibiting the proliferation of malignant T cells by administering an oligonucleotide inhibitor of miR-155.

Abstract: The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates miR-92 function and/or activity.

Abstract: The present invention provides methods for treating a neurological disease such as ALS in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for treating neuroinflammation by administering an oligonucleotide inhibitor of miR-155.

Abstract: The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such as a T cell lymphoma in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for reducing or inhibiting the proliferation of malignant T cells by administering an oligonucleotide inhibitor of miR-155.

Abstract: The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such as a T cell lymphoma in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for reducing or inhibiting the proliferation of malignant T cells by administering an oligonucleotide inhibitor of miR-155.

Abstract: The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such as a T cell lymphoma in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for reducing or inhibiting the proliferation of malignant T cells by administering an oligonucleotide inhibitor of miR-155.

Abstract: The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates miR-92 function and/or activity.

Abstract: The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such as a T cell lymphoma in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for reducing or inhibiting the proliferation of malignant T cells by administering an oligonucleotide inhibitor of miR-155.

Abstract: The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such as a T cell lymphoma in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for reducing or inhibiting the proliferation of malignant T cells by administering an oligonucleotide inhibitor of miR-155.

Abstract: The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates miR-92 function and/or activity.