Abstract: The present invention provides an A-FABP neutralizing monoclonal antibody or antigen-binding fragment thereof and a preparation method and use thereof, which comprises: complementarity determining regions 1 to 3 of a heavy chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:1-3, respectively, and/or complementarity determining regions 1-3 of the light chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:4-6. This monoclonal antibody is highly specific for A-FABP and has no cross-reactivity with human and mouse epidermal FABP and heart FABP; it has a good binding affinity for human A-FABP and mouse A-FABP; and its treatment alleviates MCAO-induced ischemic stroke injury in mice, which is associated with alleviated BBB disruption and reduced activation of pro-inflammatory JNK signaling; treatment of healthy mice for 21 days does not change physiological parameters, indicating its safety.

Abstract: A method for preparing perovskite nanopowder through a rheological phase reaction at low-temperature that can include: taking hydroxide and metallorganic compound as initial reactants; mixing and stirring the reaction raw materials to form a solid-liquid rheological phase mixture; and controlling the reaction temperature and period, under a low-temperature condition, to prepare perovskite nanopowder in nearly spherical shape and a size of 20-100 nm. This allows for advantages such as controllable product size, low cost, high yield per unit volume, environmental friendliness, high yield per unit volume, and high repeatability. The perovskite nanopowder obtained by this way is nearly spherical, are uniform in size distribution and have controllable granularity. This can be used as the ceramic substrate for electronic components such as high-end chip capacitors and PTC thermistors, etc., as well as the raw material for manufacturing ceramic 3D printing additives and electronic ceramic ink.