Patents by Inventor Aiming YU

Aiming YU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • tRNA/pre-miRNA compositions and use in treating cancer
    Patent number: 11946049
    Abstract: Provided are hybrid tRNA/pre-miRNA molecules, e.g., comprising a single tRNA and one, two or more pre-miRNA molecules, useful for the production and therapeutic delivery of an inserted RNA sequence, e.g., one or more miRNAs. Also provided are liposomes and nanoparticles that include the hybrid tRNA/pre-miRNA molecules. Methods of treating cancer by administration of the hybrid tRNA/pre-miRNA molecules are also provided.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: April 2, 2024
    Assignee: The Regents of the University of California
    Inventors: Aiming Yu, Pui Yan Ho, Meijuan Tu, Joseph L. Jilek, Qianyu Zhang, Hannah E. Petrek
  • BIOENGINEERED WNT5A THERAPEUTICS FOR ADVANCED CANCERS
    Publication number: 20230407297
    Abstract: The present disclosure provides methods and compositions for inhibiting Wnt5a expression in cells such as prostate cancer cells.
    Type: Application
    Filed: November 3, 2021
    Publication date: December 21, 2023
    Applicants: The Regents of the University of California, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Allen C. Gao, Aiming Yu
  • TRNA/pre-miRNA compositions and methods for treating hepatocellular carcinoma
    Patent number: 11702657
    Abstract: Provided are hybrid tRNA/pre-microRNA and tRNA molecules and their use in methods of preventing and treating hepatocellular carcinoma (HCC). In some embodiments, provided are polynucleotides that include a tRNA operably linked to one or more pre-microRNA (pre-miRNA), where the tRNA and/or pre-miRNA are operably linked to one or more inserted RNA molecules that inhibit the growth or proliferation of a hepatocellular carcinoma (HCC) cell.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: July 18, 2023
    Assignee: The Regents of the University of California
    Inventors: Aiming Yu, Joseph L Jilek, Qianyu Zhang, Pui Yan Ho, Meijuan Tu
  • tRNA/pre-miRNA Compositions and Use in Treating Cancer
    Publication number: 20210246446
    Abstract: Provided are hybrid tRNA/pre-miRNA molecules, e.g., comprising a single tRNA and one, two or more pre-miRNA molecules, useful for the production and therapeutic delivery of an inserted RNA sequence, e.g., one or more miRNAs. Also provided are liposomes and nanoparticles that include the hybrid tRNA/pre-miRNA molecules. Methods of treating cancer by administration of the hybrid tRNA/pre-miRNA molecules are also provided.
    Type: Application
    Filed: May 21, 2019
    Publication date: August 12, 2021
    Inventors: Aiming YU, Pui Yan HO, Meijuan TU, Joseph L. JILEK, Qianyu ZHANG, Hannah E. PETREK
  • Methods for detection of RNase activity
    Patent number: 11041201
    Abstract: Provided are polynucleotides that find use, e.g., for detecting RNase activity. In certain embodiments, the polynucleotide comprises a tRNA operably linked to a pre-microRNA (pre-miRNA), and an aptamer that binds to a detectable label. According to some embodiments, the detectable label is a fluorescent dye, non-limiting examples of which include malachite green, tetramethylrosamine, sulforhodamine B, and a triphenylmethane dye. Also provided are compositions that include the polynucleotides of the present disclosure. Also provided are kits that include a polynucleotide of the present disclosure and a detectable label to which the aptamer of the polynucleotide binds.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: June 22, 2021
    Assignee: The Regents of the University of California
    Inventor: Aiming Yu
  • tRNA/pre-miRNA Compositions and Methods For Treating Hepatocellular Carcinoma
    Publication number: 20210087564
    Abstract: Provided are hybrid tRNA/pre-microRNA and tRNA molecules and their use in methods of preventing and treating hepatocellular carcinoma (HCC). In some embodiments, provided are polynucleotides that include a tRNA operably linked to one or more pre-microRNA (pre-miRNA), where the tRNA and/or pre-miRNA are operably linked to one or more inserted RNA molecules that inhibit the growth or proliferation of a hepatocellular carcinoma (HCC) cell.
    Type: Application
    Filed: April 19, 2019
    Publication date: March 25, 2021
    Inventors: Aiming YU, Joseph L JILEK, Qianyu ZHANG, Pui Yan HO, Meijuan TU
  • Hybrid tRNA/pre-miRNA molecules and methods of use
    Patent number: 10619156
    Abstract: Provided are hybrid tRNA/pre-microRNA and tRNA/shRNA molecules and methods of making and using.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: April 14, 2020
    Assignee: The Regents of the University of California
    Inventors: Aiming Yu, Weipeng Wang, Qiuxia Chen, Meimei Li
  • METHODS FOR DETECTION OF RNASE ACTIVITY
    Publication number: 20200056236
    Abstract: Provided are polynucleotides that find use, e.g., for detecting RNase activity. In certain embodiments, the polynucleotide comprises a tRNA operably linked to a pre-microRNA (pre-miRNA), and an aptamer that binds to a detectable label. According to some embodiments, the detectable label is a fluorescent dye, non-limiting examples of which include malachite green, tetramethylrosamine, sulforhodamine B, and a triphenylmethane dye. Also provided are compositions that include the polynucleotides of the present disclosure. Also provided are kits that include a polynucleotide of the present disclosure and a detectable label to which the aptamer of the polynucleotide binds.
    Type: Application
    Filed: September 20, 2019
    Publication date: February 20, 2020
    Inventor: Aiming YU
  • Methods for detection of RNase activity
    Patent number: 10422003
    Abstract: Provided are compositions and methods for detecting RNase activity.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: September 24, 2019
    Assignee: The Regents of the University of California
    Inventor: Aiming Yu
  • METHODS FOR DETECTION OF RNASE ACTIVITY
    Publication number: 20180245152
    Abstract: Provided are compositions and methods for detecting RNase activity.
    Type: Application
    Filed: March 16, 2016
    Publication date: August 30, 2018
    Applicant: The Regents of the University of California
    Inventor: Aiming YU
  • HYBRID tRNA/pre-miRNA MOLECULES AND METHODS OF USE
    Publication number: 20180237772
    Abstract: Provided are hybrid tRNA/pre-microRNA and tRNA/shRNA molecules and methods of making and using.
    Type: Application
    Filed: May 21, 2015
    Publication date: August 23, 2018
    Applicant: The Regents of the University of California
    Inventors: Aiming YU, Weipeng WANG, Qiuxia CHEN, Meimei LI