Patents by Inventor Aiming Zhang
Aiming Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11946049Abstract: Provided are hybrid tRNA/pre-miRNA molecules, e.g., comprising a single tRNA and one, two or more pre-miRNA molecules, useful for the production and therapeutic delivery of an inserted RNA sequence, e.g., one or more miRNAs. Also provided are liposomes and nanoparticles that include the hybrid tRNA/pre-miRNA molecules. Methods of treating cancer by administration of the hybrid tRNA/pre-miRNA molecules are also provided.Type: GrantFiled: May 21, 2019Date of Patent: April 2, 2024Assignee: The Regents of the University of CaliforniaInventors: Aiming Yu, Pui Yan Ho, Meijuan Tu, Joseph L. Jilek, Qianyu Zhang, Hannah E. Petrek
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Publication number: 20240101551Abstract: A crystal form and salt form of a bromine domain protein inhibitor represented by formula (I), a preparation method therefor, and a use of the crystal form and salt form in the preparation of a drug for treating diseases mediated by BET protein.Type: ApplicationFiled: January 19, 2021Publication date: March 28, 2024Applicants: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., SHOUYAO HOLDINGS (BEIJING) CO., LTD.Inventors: Wenwei XU, Zhenliang SHAN, Yingya ZHANG, Guoliang ZHANG, Yun GE, Aiming ZHANG, Xiquan ZHANG
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Publication number: 20240093841Abstract: A misuse warning module, including a detection circuit and a warning circuit is provided. The detection circuit is electrically connected to the power circuit of the LED lamp to detect the type of external power supply signal and the current level in the power loop and output the detection signal. The warning circuit is configured to generate a misuse warning based on the detection signal to prompt the user that the LED lamp is connected to an incompatible external power supply.Type: ApplicationFiled: July 10, 2023Publication date: March 21, 2024Inventors: Aiming XIONG, Junren CHEN, Lin ZHOU, Hechen HU, Haibo YOU, Hao ZHANG
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Patent number: 11702439Abstract: The present application relates to a method for preparing trifluridine, comprising reacting a compound of formula III with a compound of formula IV in a first solvent in the presence of an acid to obtain a compound of formula II, and performing further reaction to obtain trifluridine.Type: GrantFiled: July 24, 2019Date of Patent: July 18, 2023Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.Inventors: Lin Liu, Rui Zhao, Guangming Sang, Xingjian Zhou, Xiaopeng Guo, Aiming Zhang, Gang Wu, Chunguang Xia, Xiquan Zhang
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Patent number: 11466036Abstract: A borate compound of an azetidine derivative, relating in particular to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof or a geometric isomer thereof, as well as a use thereof in the preparation of a drug used for the treatment or prevention of multiple myeloma.Type: GrantFiled: August 2, 2019Date of Patent: October 11, 2022Assignee: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.Inventors: Jian Xiong, Cheng Xie, Xiongbin Xu, Kevin X Chen, Jian Li, Shuhui Chen, Aiming Zhang, Xiquan Zhang, Xin Tian
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Patent number: 11292809Abstract: This application belongs to the field of pharmaceutical technology, and relates to the crystals of glycyrrhizic acid derivatives, their crystalline and pharmaceutical compositions, and medical use thereof, and, in particular, to the crystalline form A, crystalline form B, crystalline form C, crystalline form D, and crystalline form E of magnesium isoglycyrrhizinate, the method of preparing the crystals, the crystalline and pharmaceutical compositions containing the crystals, and medical use thereof. The crystalline forms prepared according to this application have overcome the defects of the compound of Formula I prepared according to the prior art, such as solid caking, difficult filtration, hard drying, and poor clarity. They are also suitable for industrial production, and capable of improving product safety.Type: GrantFiled: April 12, 2019Date of Patent: April 5, 2022Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.Inventors: Zhou Zhou, Wenwei Xu, Aiming Zhang, Xiquan Zhang
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Patent number: 11254665Abstract: The present application relates to a crystalline sulfamide compound, and in particular relates to a crystalline (S)—N—((S)-1-(2-chlorphenyl)-2-((3,3-difluorocyclobutyl)amido)-2oxoethyl)-2-(4-cyanopyridin-2-base)-N-(3-fluorophenyl)-isothiazolidine-3-formamide 1,1-dioxide, and a preparation method therefor, a crystalline composition, a pharmaceutical composition and uses thereof. An X-ray powder diffraction spectrum of a crystalline hydrate of formula II of the present application has diffraction peaks at positions of about 14.40°, 20.28°, 20.94°, 22.02°, and 24.46°, represented by 2?. The crystalline hydrate of formula II of the present application has good IDH1 inhibitory activity and performs high stability, and therefore has advantages in physical property, safety and metabolic stability, and has high medicine value.Type: GrantFiled: September 21, 2018Date of Patent: February 22, 2022Assignees: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD., CENTAURUS BIOPHARMA CO., LTD.Inventors: Xiquan Zhang, Wenwei Xu, Mingming Li, Minmin Kong, Shufeng Wu, Aiming Zhang
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Publication number: 20210317155Abstract: This application belongs to the field of pharmaceutical technology, and relates to the crystals of glycyrrhizic acid derivatives, their crystalline and pharmaceutical compositions, and medical use thereof, and, in particular, to the crystalline form A, crystalline form B, crystalline form C, crystalline form D, and crystalline form E of magnesium isoglycyrrhizinate, the method of preparing the crystals, the crystalline and pharmaceutical compositions containing the crystals, and medical use thereof. The crystalline forms prepared according to this application have overcome the defects of the compound of Formula I prepared according to the prior art, such as solid caking, difficult filtration, hard drying, and poor clarity. They are also suitable for industrial production, and capable of improving product safety.Type: ApplicationFiled: April 12, 2019Publication date: October 14, 2021Inventors: Zhou ZHOU, Wenwei XU, Aiming ZHANG, Xiquan ZHANG
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Publication number: 20210292356Abstract: The present application relates to a method for preparing trifluridine, comprising reacting a compound of formula III with a compound of formula IV in a first solvent in the presence of an acid to obtain a compound of formula II, and performing further reaction to obtain trifluridine.Type: ApplicationFiled: July 24, 2019Publication date: September 23, 2021Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.Inventors: Lin LIU, Rui ZHAO, Guangming SANG, Xingjian ZHOU, Xiaopeng GUO, Aiming ZHANG, Gang WU, Chunguang XIA, Xiquan ZHANG
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Patent number: 11111265Abstract: The present application relates to a method for preparing a cholic acid compound. Specifically, the method prepares a compound as shown in formula I, including subjecting a compound of formula 2 to an oxidization reaction to obtain a compound of formula 3; attaching a trimethylsilyl group to the compound of formula 3 to obtain a compound of formula 4; reacting the compound of formula 4 with acetaldehyde to obtain a compound of formula 5; subjecting the compound of formula 5 to a catalytic hydrogenation reaction to obtain a compound of formula 6; and converting a cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I.Type: GrantFiled: November 1, 2018Date of Patent: September 7, 2021Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.Inventors: Xiquan Zhang, Xingdong Cheng, Aiming Zhang, Chunguang Xia, Lang Chen, Ce Gao
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Publication number: 20210163507Abstract: A borate compound of an azetidine derivative, relating in particular to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof or a geometric isomer thereof, as well as a use thereof in the preparation of a drug used for the treatment or prevention of multiple myeloma.Type: ApplicationFiled: August 2, 2019Publication date: June 3, 2021Inventors: Jian Xiong, Cheng Xie, Xiongbin Xu, Kevin X Chen, Jian Li, Shuhui Chen, Aiming Zhang, Xiquan Zhang, Xin Tian
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Patent number: 11014943Abstract: Disclosed in the present application are a compound represented by formula (I), or a pharmaceutically acceptable salt, a tautomer thereof, a stereoisomer thereof, or a geometrical isomer thereof, and uses thereof in the preparation of drugs for treating or preventing multiple myeloma.Type: GrantFiled: February 28, 2018Date of Patent: May 25, 2021Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP GO., LTD.Inventors: Jian Xiong, Cheng Xie, Kevin X Chen, Xiongbin Xu, Xuejin Zhang, Zhen Gong, Jian Li, Shuhui Chen, Aiming Zhang, Zhulian Jiang, Xiquan Zhang, Xin Tian
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Publication number: 20200347091Abstract: The present application belongs to the field of pharmaceutical chemistry, and relates to a method for preparing a cholic acid compound. Specifically, the present application provides a process for preparing a compound as shown in formula I, comprising subjecting a compound of formula 2 to an oxidization reaction to obtain a compound of formula 3; attaching a trimethylsilyl group to the compound of formula 3 to obtain a compound of formula 4; reacting the compound of formula 4 with acetaldehyde to obtain a compound of formula 5; subjecting the compound of formula 5 to a catalytic hydrogenation reaction to obtain a compound of formula 6; and converting a cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I. The preparation method has high yield, requires less purification operations, and is suitable for industrial application.Type: ApplicationFiled: November 1, 2018Publication date: November 5, 2020Inventors: Xiquan ZHANG, Xingdong CHENG, Aiming ZHANG, Chunguang XIA, Lang CHEN, Ce GAO
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Patent number: 10822319Abstract: The present application relates to a crystal of a compound represented by Formula (I), a salt thereof, and a crystal of the salt thereof, a method for preparing the crystal of the compound represented by Formula (I), the salt thereof, and the crystal of the salt thereof, a crystal comprising the compound represented by Formula (I), a crystal composition comprising the crystal of the salt thereof, a pharmaceutical composition thereof, and medical uses thereof.Type: GrantFiled: August 11, 2017Date of Patent: November 3, 2020Assignees: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD., CENTAURUS BIOPHARMA CO., LTD.Inventors: Guangming Sang, Lin Liu, Aiming Zhang, Jiabin Qiao, Xiaopeng Guo, Xiquan Zhang, Chunguang Xia
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Publication number: 20200291012Abstract: The present application relates to a crystalline sulfamide compound, and in particular relates to a crystalline (S)-N-((S)-1-(2-chlorphenyl)-2-((3,3-difluorocyclobutyl)amido)-2oxoethyl)-2-(4-cyanopyridin-2-base)-N-(3-fluorophenyl)-isothiazolidine-3-formamide 1,1-dioxide, and a preparation method therefor, a crystalline composition, a pharmaceutical composition and uses thereof. An X-ray powder diffraction spectrum of a crystalline hydrate of formula II of the present application has diffraction peaks at positions of about 14.40°, 20.28°, 20.94°, 22.02°, and 24.46°, represented by 2?. The crystalline hydrate of formula II of the present application has good IDH1 inhibitory activity and performs high stability, and therefore has advantages in physical property, safety and metabolic stability, and has high medicine value.Type: ApplicationFiled: September 21, 2018Publication date: September 17, 2020Applicants: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD., CENTAURUS BIOPHARMA CO., LTD.Inventors: Xiquan ZHANG, Wenwei XU, Mingming LI, Minmin KONG, Shufeng WU, Aiming ZHANG
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Patent number: 10766901Abstract: Provided are a preparation method for a chiral pyrrolopyrimidine compound and a related intermediate. In the method, a compound of formula A and a compound of formula 6 or a salt thereof are reacted to obtain a compound of formula 7 or a compound of formula 14, and a compound of formula I is prepared from the compound of formula 7 or the compound of formula 14. Also provided are the intermediate used, a preparation method for the intermediate and a use of the intermediate in the preparation of the compound of formula I. The preparation method has characteristics such as brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and a convenient post-treatment. The method avoids using an expensive asymmetric reaction catalyst, and is suitable for industrial production.Type: GrantFiled: June 15, 2017Date of Patent: September 8, 2020Assignees: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD., CENTAURUS BIOPHARMA CO., LTD.Inventors: Xiquan Zhang, Aiming Zhang, Zhou Zhou, Huadong Yao, Jie Xie
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Patent number: 10626118Abstract: The present application relates to the field of pharmaceutical chemistry. The application specifically relates to a crystal form A and crystal form B of a pyrrolopyrimidine (formula I) for preparing a JAK inhibitor. The application further relates to a method for preparing the crystal form A and crystal form B, a crystalline composition comprising the crystal form A or crystal form B, a pharmaceutical composition comprising the crystal form A, crystal form B, or crystalline composition, and a pharmaceutical application of the pharmaceutical composition, the crystal form A, and the crystal form B. The crystal form A and crystal form B of the application has the advantages of high purity, high crystallinity, and good stability.Type: GrantFiled: June 15, 2017Date of Patent: April 21, 2020Assignees: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD., CENTAURUS BIOPHARMA CO., LTD.Inventors: Zhou Zhou, Aiming Zhang, Xiquan Zhang, Huadong Yao
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Publication number: 20200115392Abstract: Disclosed in the present application are a compound represented by formula (I), or a pharmaceutically acceptable salt, a tautomer thereof, a stereoisomer thereof, or a geometrical isomer thereof, and uses thereof in the preparation of drugs for treating or preventing multiple myeloma.Type: ApplicationFiled: February 28, 2018Publication date: April 16, 2020Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.Inventors: Jian XIONG, Cheng XIE, Kevin X CHEN, Xiongbin XU, Xuejin ZHANG, Zhen GONG, Jian LI, Shuhui CHEN, Aiming ZHANG, Zhulian JIANG, Xiquan ZHANG, Xin TIAN
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Patent number: 10562904Abstract: The present application falls within the field of drug synthesis, and in particular, the present application relates to a method for preparing ruxolitinib, and a method for preparing the intermediate and relevant intermediates used. The method comprises reacting a compound of formula II with a compound of formula IV or a salt thereof to obtain a compound of formula III, and then subjecting the compound of formula III to an acyl halogenation reaction, an amidation reaction, and a reaction dehydrating an amide to form a cyano group or removing the protecting group to prepare ruxolitinib. The method has the characteristics of brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and convenient post treatment. The method avoids using expensive asymmetric reaction catalysts, and is suitable for industrial production.Type: GrantFiled: December 29, 2016Date of Patent: February 18, 2020Assignee: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.Inventors: Xiquan Zhang, Aiming Zhang, Zhou Zhou, Leilei Yang, Huadong Yao, Xueyan Zhu, Hubo Wang
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Publication number: 20190330215Abstract: The present application relates to the field of pharmaceutical chemistry. The application specifically relates to a crystal form A and crystal form B of a pyrrolopyrimidine (formula I) for preparing a JAK inhibitor. The application further relates to a method for preparing the crystal form A and crystal form B, a crystalline composition comprising the crystal form A or crystal form B, a pharmaceutical composition comprising the crystal form A, crystal form B, or crystalline composition, and a pharmaceutical application of the pharmaceutical composition, the crystal form A, and the crystal form B. The crystal form A and crystal form B of the application has the advantages of high purity, high crystallinity, and good stability.Type: ApplicationFiled: June 15, 2017Publication date: October 31, 2019Inventors: Zhou Zhou, Aiming Zhang, Xiquan Zhang, Huadong Yao