Abstract: Door and window frame, comprising a quadrangular frame formed by four section bars each having an outer side provided with a longitudinal groove, in which the longitudinal groove comprises a base, two parallel lateral walls and two edges oriented towards each other and defining an undercut engagement area at each of said lateral walls, and a drive assembly comprising a plurality of actuating members and a plurality of transmission rods that engage respective longitudinal grooves, and having each a single tenon. The tenons of the actuating members and of the transmission rods all engage the same undercut engagement area of the respective groove.