Patents by Inventor Ainara González Cabodevilla

Ainara González Cabodevilla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APOLIPOPROTEIN B (APOB) POLYPEPTIDES FOR BLOCKING ENDOTHELIAL CELL UPTAKE OF APOLIPOPROTEIN B-CONTAINING LIPOPROTEINS
    Publication number: 20240109953
    Abstract: The present disclosure provides polypeptides comprising an N-terminal portion(s) of Apolipoprotein B100 (ApoB100), or functional derivatives thereof, particularly polypeptides may be capable of, e.g., inhibiting scavenger receptor-B1 (SR-B1) and/or activin receptor-like kinase 1 (ALK1). Further provided are related polynucleotides, vectors, and pharmaceutical compositions. Methods for blocking endothelial cell uptake and/or transcytosis of lipoproteins comprising chylomicrons, low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and/or lipoprotein (a) (Lp(a)) and treating atherosclerosis using the polypeptides and/or pharmaceutical compositions are also provided.
    Type: Application
    Filed: May 10, 2023
    Publication date: April 4, 2024
    Applicant: New York University
    Inventors: Ira J. Goldberg, Ainara González Cabodevilla, M. Mahmood Hussain