Abstract: Provided herein are compositions, methods, and systems, comprising a programmable nucleic acid-guided nuclease and sequence-diverged donor sequences. The compositions and methods described herein facilitate editing of a targeted locus using a diverged sequence encoding for a functional protein product.

Abstract: A computing device determines an optimal number of threads for a computer task. Execution of a computing task is controlled in a computing environment based on each task configuration included in a plurality of task configurations to determine an execution runtime value for each task configuration. An optimal number of threads value is determined for each set of task configurations having common values for a task parameter value, a dataset indicator, and a hardware indicator. The optimal number of threads value is an extremum value of an execution parameter value as a function of a number of threads value. A dataset parameter value is determined for a dataset. A hardware parameter value is determined as a characteristic of each distinct executing computing device in the computing environment. The optimal number of threads value for each set of task configurations is stored in a performance dataset in association with the common values.