Patents by Inventor Ajay A. Rege

Ajay A. Rege has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mitomycin oligonucleotide conjugates
    Patent number: 5776907
    Abstract: The present invention provides conjugates of mitomycin C or derivatives thereof and oligonucleotides. A conjugate of the present invention corresponds to formula I, below: ##STR1## where R is H, CH.sub.3, or C(O)SCH.sub.3, R' is O or NH, m is an integer from 1 to 10 and Ogn is an oligonucleotide. Pharmaceutical compositions and methods of using such conjugates to inhibit gene product expression are also provided.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: July 7, 1998
    Assignee: Texas Biotechnology Corporation
    Inventors: Harold L. Kohn, Nam Huh, Timothy P. Kogan, Ajay A. Rege