Abstract: An embolic coil is formed from a continuous wire and has a primary shape formed by winding the wire on a tapered mandrel such that the primary shape of the coil is a spiral having an outer diameter that increases from a first outer diameter at the proximal end to a second outer diameter at the distal end that is larger than the first outer diameter. The coil has the primary shape when constrained within a delivery catheter. The coil has a gradient stiffness profile transitioning from a first stiffness at the proximal end to a second stiffness at the distal end that is less than the first stiffness. The coil has a secondary shape after exiting the delivery catheter that includes at least one loop or fold formed from the spiral of the primary shape.

Abstract: Embodiments herein relate to devices for delivering fluid-based therapies into a target vessel of a patient. In an embodiment, an apparatus is included having a microcatheter. The microcatheter can include a catheter shaft having a lumen therein. The microcatheter can have an open end that is at a distal end of the catheter shaft. The microcatheter can have a plurality of side apertures disposed within a side wall of the catheter shaft. The plurality of side apertures allow for a fluid to pass from the lumen to the outside of the catheter shaft. The apparatus further includes a seal element configured to pass through the lumen of the microcatheter. The seal element can include a shaft and an occlusion member configured to at least partially occlude the open end of the microcatheter directing fluid flow through the plurality of side apertures. Other embodiments are also included herein.

Abstract: An apparatus is configured to operate one of a pretrained or a pretrained and fine-tuned generative artificial intelligence (AI) foundation model (the generative AI foundation model), pretrained or pretrained and fine-tuned using at least a wireless language that models a wireless protocol, to receive a wireless input according to the wireless protocol, convert the wireless input into the wireless language, convert the wireless language into tokens, map each of the tokens to the generative AI foundation model as embeddings, capture patterns and relationships between the embeddings, expressed implicitly in statistics, using the generative AI foundation model, and apply the statistics, an output of the generative AI foundation model, or both to a dynamic memory management controller. The dynamic memory management controller adapts an amount of hybrid automatic repeat request (HARQ) buffer memory and/or logical channel buffer memory to allocate or release in the one or more memories.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a first network node in a radio access network (RAN) may transmit mobility history data for a user equipment (UE) to a second network node in a core network associated with the RAN. The first network node may receive a UE mobility prediction model that is based at least in part on the mobility history data from the second network node. Numerous other aspects are described.

Abstract: A medical assembly includes an implantable medical device and an elongate delivery member that is adapted to deliver the implantable medical device. The implantable medical device is releasably secured to the elongate delivery member. An outer sheath is adapted to fit over the elongate delivery member. A removable coupler is adapted to secure the elongate delivery member in position relative to the outer sheath when the removable coupler is disposed between the elongate delivery method and the outer sheath.

Abstract: A chemotherapy agent comprising a chemotherapy group and a ligand secured to the chemotherapy group is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing chemotherapy agents from a patient is disclosed, the method comprising providing a chemotherapy agent containing a reactive group; providing a capture substrate in contact with a patient's bloodstream; administering the chemotherapy agent to the patient; and sequestering the chemotherapy agent on the capture substrate. A system for removing chemotherapy agents is also disclosed.

Abstract: Embodiments herein relate to dispersion catheter systems and related methods. In an embodiment, a dispersion catheter system for delivering injectates to small diameter vessels of a patient is included having a dispersion catheter shaft defining a lumen and a dispersion catheter tip in fluid communication with the lumen of the dispersion catheter shaft. The dispersion catheter system can also include a fluid dispersal cap, wherein the fluid dispersal cap is configured to be disposed within a path of fluid flow coming from the dispersion catheter tip. The fluid dispersal cap can have one or more internal flow conduits, side flow ports, side flow channels, and/or outflow ports. Other embodiments are also included herein.

Abstract: A medical device includes an end effector assembly at a distal end of the medical device. The assembly comprises a pair of jaw members, a pair of electrodes including first and second electrodes, and first and second conductive wires attached to the first and second electrodes, respectively. Each jaw member includes a jaw and a tang, the jaw being transitionable between open and closed configurations for respectively receiving and collecting a tissue portion as a sample. The first and second conductive wires extend to a proximal end of the medical device and are removably connectable to a computing device configured to generate and provide electrical signals to, and determine an impedance measurement of the tissue portion based on response signals received from, the pair of electrodes contacting the tissue portion, and generate and provide a user interface indicating whether to collect the tissue portion based on the impedance measurement.

Abstract: An artery can be occluded by implanting an occlusion implant within a subintimal space within a wall of the artery. As an example, a catheter having a side port just proximal of an inflatable balloon disposed near a distal end of the catheter can be advanced through the artery to a site at which an occlusion is desired. The inflatable balloon can be inflated and a guidewire can be advanced through a lumen of the catheter, out of the side port and into a subintimal space of the artery, with the inflated inflatable balloon guiding the guidewire towards the artery wall. An occlusion implant can be advanced over the guidewire into the subintimal space and the guidewire can be withdrawn, leaving the occlusion implant positioned within the subintimal space.

Abstract: A pharmaceutical composition is provided which contains a phospholipid-containing composition which antagonizes toll-like receptors 1, 2, 3, 6, 7, 8 and 10. The phospholipid-containing composition consists of regioisomers and stereoisomers of palmitoyloleoylphosphatidylglycerol (POPG) consisting of at least 80% of 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1?-rac-glycerol) or a salt thereof, and no more than 20% of its regioisomer 1-oleoyl-2-palmitoyl-sn-glycero-3-phospho-(1?-rac-glycerol) or a salt thereof. The phospholipid-containing composition also has enantiomeric enrichment with at least 51% of the dextro rotatory isomer at the sn-2 position of the terminal glycerol moiety.

Abstract: Devices and/or adapters for use with a syringe are disclosed. An example device for use with a syringe may include a first member having a holding region configured to engage a flange of a syringe barrel. The device may also include a second member coupled to the first member. The second member may have an end surface configured to engage a syringe plunger. Relative movement between the first member and the second member may shift the syringe plunger within the syringe barrel.

Abstract: A circuit arrangement includes a preprocessing circuit configured to obtain context information related to a user location, a learning circuit configured to determine a predicted user movement based on context information related to a user location to obtain a predicted route and to determine predicted radio conditions along the predicted route, and a decision circuit configured to, based on the predicted radio conditions, identify one or more first areas expected to have a first type of radio conditions and one or more second areas expected to have a second type of radio conditions different from the first type of radio conditions and to control radio activity while traveling on the predicted route according to the one or more first areas and the one or more second areas.

Abstract: A lipid nanoparticle based composition and method for making the same is provided. The lipid nanoparticle based composition includes an in-vitro transcribed (IVT) mRNA molecule containing (a) a 5? cap structure, (b) a coding region encoding an antigen polypeptide, (c) an immunostimulatory RNA sequence that activates RIG-I, (d) a poly (A) tail, and (e) a TLR antagonist based on a phospholipid.

Abstract: Methods, systems, and devices for wireless communications are described. The described techniques provide for detecting when a control link between a user equipment (UE) and a base station is lost and recovering the control link. In one example, a UE may detect that a control link with a base station is lost based on a timer or counter expiring or based on failing to receive signaling from the base station. In another example, a UE may be configured to transmit uplink transmissions to a base station to maintain a control link with the base station, and the base station may detect that a control link with the UE is lost if the base station fails to receive one or more uplink transmissions from the UE. If the control link is lost, the base station and the UE may communicate to re-establish the control link.

Abstract: Systems and methods are described herein for updating links between keywords associated with a trending topic. Control circuitry may identify a plurality of communications associated with a plurality of users, the plurality of communications being related to a topic. The communications may comprise, for example, emails, text messages, online social media posts, websites or portions of a website, or any other online communication. The control circuitry may determine whether the topic is trending and increase a strength of association between a first symbol associated with the topic and a second symbol associated with the topic such that when a search query is received that includes the first symbol, search results related to the second symbol have a higher probability of being returned.

Abstract: Embodiments herein relate to flow control devices for cancer treatment systems and related methods. In an embodiment, a fluid flow control device for a cancer therapy system is included having a receiver housing, wherein the receiver housing can be configured to interface with a fluid delivery device. The fluid flow control device can also include a rotational plunger. The rotational plunger can include indicia, such as markings, on an end of the rotational plunger. The rotational plunger can be configured to engage with the receiver housing and rotation of the rotational plunger causes a plunger of the syringe to be depressed. Other embodiments are also included herein.

Abstract: Locking catheters including a fluid-tight hub and mechanism to secure a flexible member. An illustrative locking catheter may comprise an elongate shaft defining a lumen, a first connection member coupled to the elongate shaft, a second connection member configured to be releasably coupled to the first connection member, and a flexible member extending through at least a portion of a lumen of the elongate shaft and a portion of a lumen of the first connection member. The proximal end of the flexible member may extend through the aperture of the first connection member such that the proximal end of the flexible member is exterior to the first connection member. When the second connection member is coupled with the first connection member, the flexible member may be secured between an inner surface of the first connection member and an outer surface of the inner tubular member of the second connection member.

Abstract: Methods, systems, and devices for wireless communications are described. The described techniques provide for detecting when a control link between a user equipment (UE) and a base station is lost and recovering the control link. In one example, a UE may detect that a control link with a base station is lost based on a timer or counter expiring or based on failing to receive signaling from the base station. In another example, a UE may be configured to transmit uplink transmissions to a base station to maintain a control link with the base station, and the base station may detect that a control link with the UE is lost if the base station fails to receive one or more uplink transmissions from the UE. If the control link is lost, the base station and the UE may communicate to re-establish the control link.

Abstract: A balloon for renal nerve modulation is disclosed. The balloon may include a polymer material forming a balloon wall having an outer surface and flexible circuits comprising a base selectively adhered to the exterior surface of the balloon wall. Adhesive is selectively applied to the outer surface of the balloon, to the flexible circuit or to both such that the adhesive is selectively deposited on the at least a portion of the at least two pads or on the at least a portion of the at least two pads and to a portion of the distal spline. The portion of the at least two pads or the portion of the at least two pads and a portion of the distal spline are adhered to the outer surface of the balloon and a remainder of the flexible circuit moves freely with respect to the outer surface of the balloon.

Abstract: Systems and methods are described herein for updating links between keywords associated with a trending topic. Control circuitry may identify a plurality of communications associated with a plurality of users, the plurality of communications being related to a topic. The communications may comprise, for example, emails, text messages, online social media posts, websites or portions of a website, or any other online communication. The control circuitry may determine whether the topic is trending and increase a strength of association between a first symbol associated with the topic and a second symbol associated with the topic such that when a search query is received that includes the first symbol, search results related to the second symbol have a higher probability of being returned.