Patents by Inventor Ajay Jaysingh Khopade
Ajay Jaysingh Khopade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190070176Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.Type: ApplicationFiled: November 5, 2018Publication date: March 7, 2019Applicant: Sun Pharma Advanced Research Company LimitedInventors: Ajay Jaysingh Khopade, Arindam Halder
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Publication number: 20190008772Abstract: The present invention relates to nano-resin particles that are suitable for pharmaceutical use and their use in the pharmaceutical field. The present invention provides nano-sized resin particles having a particle size distribution characterized in that D90 value is between 200 nanometers to 900 nanometer and D10 value is not less than 50 nanometers, wherein the nano-resin particles are in pure form and safe for pharmaceutical use. The present invention further relates to pharmaceutical compositions comprising these purified nano-resin particles and their use in the treatment of diseases.Type: ApplicationFiled: July 27, 2016Publication date: January 10, 2019Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Ajay Jaysingh Khopade, Arindam Halder, Shivam Umeshkumar Upadhyay
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Patent number: 10172852Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.Type: GrantFiled: July 24, 2015Date of Patent: January 8, 2019Assignee: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Ajay Jaysingh Khopade, Arindam Halder
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Publication number: 20180311159Abstract: The present invention provides a method of treatment of inflammatory disorder of the eye, said method comprising administering into the eye of a person in need thereof, an aqueous solution comprising difluprednate as the sole active ingredient at a concentration of 0.02% to 0.04% weight by volume in an aqueous vehicle, wherein the solution is free of oil and wherein the solution is administered twice-a-day. The present invention also provides an ophthalmic solution comprising a. therapeutically effective concentration of difluprednate, a crystal growth inhibitor and pharmaceutically acceptable amounts of a solubilizer comprising a mixture of i. quaternary ammonium compound and ii. polyethoxylated castor oil, b. in an aqueous vehicle. wherein the crystal growth inhibitor is polyvinyl alcohol or its derivatives.Type: ApplicationFiled: October 15, 2016Publication date: November 1, 2018Applicant: Sun Pharma Advanced Research Company LimitedInventors: Ajay Jaysingh Khopade, Arindam Halder, Ankit Shaileshkumar Shah
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Publication number: 20180296571Abstract: The present invention provides an ophthalmic solution comprising a. therapeutically effective concentration of difluprednate, a crystal growth inhibitor and pharmaceutically acceptable amounts of a solubilizer comprising a mixture of i. quaternary ammonium compound and ii. polyethoxylated castor oil, b. in an aqueous vehicle. wherein the crystal growth inhibitor is polyvinyl alcohol or its derivatives. Also, the present invention provides a method of treatment of inflammatory disorder of the eye, said method comprising administering into the eye of a person in need thereof, an aqueous solution comprising difluprednate as the sole active ingredient at a concentration of 0.02% to 0.04% weight by volume in an aqueous vehicle, wherein the solution is free of oil and wherein the solution is administered twice-a-day.Type: ApplicationFiled: October 15, 2016Publication date: October 18, 2018Applicant: Sun Pharma Advanced Research Company LimitedInventors: Ajay Jaysingh Khopade, Arindam Halder, Ankit Shaileshkumar Shah
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Publication number: 20180221451Abstract: The present invention relates to a composition comprising particles, wherein said particles comprise Poly(lactide-co-glycolide) polymer, therapeutically effective amount of liraglutide or a pharmaceutically acceptable salt thereof and a hydrophilic particle size modulating agent, wherein, the composition is free of added divalent metal ions. The composition provides effective blood glucose control for about 7 days when administered as once a week formulation to a period of about 30 days after single administration of a monthly dose to a patient in need thereof.Type: ApplicationFiled: August 12, 2016Publication date: August 9, 2018Applicant: Sun Pharma Advanced Research Company LimitedInventors: Ajay Jaysingh Khopade, Arindam Halder, Vivek Patel
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Publication number: 20180169010Abstract: The present invention relates to a long acting composition comprising, therapeutically effective amount of liraglutide, a block or a graft copolymer comprising hydrophilic and hydrophobic moieties or mixtures thereof, at least one amphipath, and an aqueous vehicle, wherein the composition is in the form of a gel which is rendered injectable when forced through a needle by means of a plunger. The composition provides effective blood glucose control for about 6 days to about 14 days after single administration to a subject in need thereof, in particularly for about a week.Type: ApplicationFiled: June 16, 2016Publication date: June 21, 2018Applicant: Sun Pharma Advanced Research Company LimitedInventors: Ajay Jaysingh Khopade, Arindam Halder, Vivek Patel
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Publication number: 20170239243Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.Type: ApplicationFiled: July 24, 2015Publication date: August 24, 2017Applicant: Sun Pharma Advanced Research Company LimitedInventors: Ajay Jaysingh Khopade, Arindam Halder
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Patent number: 9629852Abstract: The present invention relates to a pharmaceutical composition suitable for ophthalmic use comprising one or more prostaglandin derivatives or salts, a stabilizing amount of polyethylene glycol hydroxystearate and pharmaceutically acceptable vehicle.Type: GrantFiled: October 15, 2008Date of Patent: April 25, 2017Assignee: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Ajay Jaysingh Khopade, Arindam Halder, Subhas Balaram Bhowmick
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Patent number: 9539262Abstract: The present invention relates to a pharmaceutical composition suitable for ophthalmic use comprising one or more prostaglandin derivatives or salts, a stabilizing amount of polyethylene glycol hydroxystearate and pharmaceutically acceptable vehicle.Type: GrantFiled: April 20, 2015Date of Patent: January 10, 2017Assignee: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Ajay Jaysingh Khopade, Arindam Halder, Subhas Balaram Bhowmick
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Publication number: 20150290216Abstract: The present invention relates to a pharmaceutical composition suitable for ophthalmic use comprising one or more prostaglandin derivatives or salts, a stabilizing amount of polyethylene glycol hydroxystearate and pharmaceutically acceptable vehicle.Type: ApplicationFiled: April 20, 2015Publication date: October 15, 2015Inventors: Ajay Jaysingh KHOPADE, Arindam HALDER, Subhas Balaram BHOWMICK
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Patent number: 8778364Abstract: A nanodispersion containing nanoparticles having a mean size less than 300 nm dispersed in a vehicle that includes a water miscible solvent and water. The nanoparticles contain one or more drugs, a polymer and a surfactant, and the surfactant includes a mixture of fatty acids or its salts and sterol or its derivatives or its salts.Type: GrantFiled: June 18, 2010Date of Patent: July 15, 2014Assignee: Sun Pharma Advanced Research Company Ltd.Inventors: Ajay Jaysingh Khopade, Natarajan Arulsudar, Subhas Balaram Bhowmick
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Publication number: 20140030352Abstract: The present invention provides a nanodispersion comprising nanoparticles having a mean size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said nanoparticles comprising one or more taxane derivative, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts.Type: ApplicationFiled: October 3, 2013Publication date: January 30, 2014Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Ajay Jaysingh KHOPADE, Subhas Balaram BHOWMICK, Natarajan ARULSUDAR
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Patent number: 8586062Abstract: The present invention provides a nanodispersion comprising nanoparticles having a mean size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said nanoparticles comprising one or more taxane derivative, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts.Type: GrantFiled: December 23, 2008Date of Patent: November 19, 2013Assignee: Sun Pharma Advanced Research Company Ltd.Inventors: Ajay Jaysingh Khopade, Subhas Balaram Bhowmick, Natarajan Arulsudar
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Publication number: 20130267591Abstract: An ophthalmic solution comprising therapeutically effective amount of a prostaglandin or its analog and water soluble excipient(s) dissolved in a pharmaceutically acceptable vehicle, wherein the solution is free of a surfactant.Type: ApplicationFiled: May 6, 2011Publication date: October 10, 2013Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Ajay Jaysingh Khopade, Arindam Halder, Subhas Balaram Bhowmick
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Publication number: 20120087959Abstract: The present invention provides a nanodispersion comprising nanoparticles having a mean size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said nanoparticles comprising one or more drugs, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts.Type: ApplicationFiled: June 18, 2010Publication date: April 12, 2012Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Ajay Jaysingh Khopade, N Arulsudar, Subhas Balaram Bhowmick
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Publication number: 20110003816Abstract: An ophthalmic composition comprising therapeutically effective amount of a beta-blocker and a polymeric vehicle consisting essentially of a water soluble cellulose derivative and polyvinylpyrrolidone; wherein the composition is a clear aqueous solution with a viscosity id 20 cps to 60 cps.Type: ApplicationFiled: March 9, 2009Publication date: January 6, 2011Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Arindam Halder, Ajay Jaysingh Khopade, Subhas Balaram Bowmick
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Publication number: 20100297244Abstract: The present invention provides a nanodispersion comprising nanoparticles having a mean size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said nanoparticles comprising one or more taxane derivative, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts.Type: ApplicationFiled: December 23, 2008Publication date: November 25, 2010Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Ajay Jaysingh Khopade, Subhas Balaram Bhowmick, Natarajan Arulsudar
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Publication number: 20100137432Abstract: The present invention relates to a pharmaceutical composition suitable for ophthalmic use comprising one or more prostaglandin derivatives or salts, a stabilizing amount of polyethylene glycol hydroxystearate and pharmaceutically acceptable vehicle.Type: ApplicationFiled: October 15, 2008Publication date: June 3, 2010Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Ajay Jaysingh Khopade, Arindam Halder, Subhas Balaram Bhowmick