Patents by Inventor Ajay M. Shah

Ajay M. Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method for correcting patient index
    Patent number: 11964281
    Abstract: A system and/or method for determining an immune activation state of a subject can include: deforming leukocytes within a microfluidic channel, acquiring a plurality of images of the leukocytes, determining biophysical parameters of the leukocyte, adjusting the biophysical parameters, and determining the immune activation state of the subject based on the biophysical parameters.
    Type: Grant
    Filed: February 3, 2022
    Date of Patent: April 23, 2024
    Assignee: CytoVale Inc.
    Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Roya Sheybani, Audun Johnson, Peter Landwehr, Hunter Stevenson
  • SYSTEM AND METHOD FOR CORRECTING PATIENT INDEX
    Publication number: 20230241612
    Abstract: A system and/or method for determining an immune activation state of a subject can include: deforming leukocytes within a microfluidic channel, acquiring a plurality of images of the leukocytes, determining biophysical parameters of the leukocyte, adjusting the biophysical parameters, and determining the immune activation state of the subject based on the biophysical parameters.
    Type: Application
    Filed: February 3, 2022
    Publication date: August 3, 2023
    Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Roya Sheybani, Audun Johnson, Peter Landwehr, Hunter Stevenson
  • SYSTEM AND METHOD FOR CORRECTING PATIENT INDEX
    Publication number: 20230241613
    Abstract: A system and/or method for determining an immune activation state of a subject can include: deforming leukocytes within a microfluidic channel, acquiring a plurality of images of the leukocytes, determining biophysical parameters of the leukocyte, adjusting the biophysical parameters, and determining the immune activation state of the subject based on the biophysical parameters.
    Type: Application
    Filed: June 15, 2022
    Publication date: August 3, 2023
    Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Roya Sheybani, Audun Johnson, Peter Landwehr, Hunter Stevenson
  • SYSTEM AND METHOD FOR DETERMINING AN IMMUNE ACTIVATION STATE
    Publication number: 20230221224
    Abstract: A method and/or system can include processing a blood sample of a patient by degrading red blood cells of the blood sample using a lysing solution, quenching the degradation of the red blood cells after a threshold lysing time, centrifuging and aspirating the quenched solution to remove degraded red blood cell debris and concentrate white blood cells of the blood sample, and suspending the concentrated white blood cells in a buffer solution; within a threshold transfer time, deforming white blood cells, of the suspended white blood cells, within a microfluidic chip; and determining a probability that the patient is in an immune activation state based on images of the white blood cells acquired while deforming the white blood cells.
    Type: Application
    Filed: June 15, 2022
    Publication date: July 13, 2023
    Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Alexander Malkin, Anne E. Jensen, Nicholas Martinez, Carissa Colegrove, Laura Voyen
  • SYSTEM AND METHOD FOR DETERMINING AN IMMUNE ACTIVATION STATE
    Publication number: 20230219087
    Abstract: A system or method for detecting an immune system activation state in a patient can include a sample preparation system configured to isolate white blood cells from a sample of the patient, a cytometry module configured to determine biophysical properties of the white blood cells of the sample, and an analysis module configured to analyze the biophysical properties.
    Type: Application
    Filed: June 15, 2022
    Publication date: July 13, 2023
    Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Alexander Malkin, Anne E. Jensen, Nicholas Martinez, Carissa Colegrove, Laura Voyen
  • System and method for determining an immune activation state
    Patent number: 11592371
    Abstract: A method and/or system can include processing a blood sample of a patient by degrading red blood cells of the blood sample using a lysing solution, quenching the degradation of the red blood cells after a threshold lysing time, centrifuging and aspirating the quenched solution to remove degraded red blood cell debris and concentrate white blood cells of the blood sample, and suspending the concentrated white blood cells in a buffer solution; within a threshold transfer time, deforming white blood cells, of the suspended white blood cells, within a microfluidic chip; and determining a probability that the patient is in an immune activation state based on images of the white blood cells acquired while deforming the white blood cells.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: February 28, 2023
    Assignee: CytoVale Inc.
    Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Alexander Malkin, Anne E. Jensen, Nicholas Martinez, Carissa Colegrove, Laura Voyen
  • System and method for determining an immune activation state
    Patent number: 11548003
    Abstract: A system or method for detecting an immune system activation state in a patient can include a sample preparation system configured to isolate white blood cells from a sample of the patient, a cytometry module configured to determine biophysical properties of the white blood cells of the sample, and an analysis module configured to analyze the biophysical properties.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: January 10, 2023
    Assignee: CytoVale Inc.
    Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Alexander Malkin, Anne E. Jensen, Nicholas Martinez, Carissa Colegrove, Laura Voyen
  • SYSTEM AND METHOD FOR IMMUNE ACTIVITY DETERMINATION
    Publication number: 20210370301
    Abstract: A system and method for determining a trajectory parameter of particles, comprising receiving a plurality of particles at a microfluidic channel, applying a force to each particle of the microfluidic channel, acquiring a dataset of each particle, measuring a trajectory of the particle, and determining a trajectory parameter of the particles.
    Type: Application
    Filed: August 13, 2021
    Publication date: December 2, 2021
    Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Roya Sheybani, Christopher Dahlberg, Anne E. Jensen
  • System and method for immune activity determination
    Patent number: 11123734
    Abstract: A system and method for determining a trajectory parameter of particles, comprising receiving a plurality of particles at a microfluidic channel, applying a force to each particle of the microfluidic channel, acquiring a dataset of each particle, measuring a trajectory of the particle, and determining a trajectory parameter of the particles.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: September 21, 2021
    Assignee: CytoVale Inc.
    Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Roya Sheybani, Christopher Dahlberg, Anne E. Jensen
  • SYSTEM AND METHOD FOR IMMUNE ACTIVITY DETERMINATION
    Publication number: 20210031198
    Abstract: A system and method for determining a trajectory parameter of particles, comprising receiving a plurality of particles at a microfluidic channel, applying a force to each particle of the microfluidic channel, acquiring a dataset of each particle, measuring a trajectory of the particle, and determining a trajectory parameter of the particles.
    Type: Application
    Filed: July 30, 2020
    Publication date: February 4, 2021
    Inventors: Henry Tat Kwong Tse Kwong, Ajay M. Shah, Lionel Guillou, Roya Sheybani, Christopher Dahlberg, Anne E. Jensen