Abstract: This invention relates to an improved and scalable process for the preparation of substantially pure palonosetron and its acid addition salts, in particular hydrochloride (I) which comprises of, (a) converting intermediate (IIa) as such or as its freebase (II) to a crude mixture of diastereomeric palonosetrons (VIII) or (VIIIa) contaminated with varying amounts of unconverted intermediate (II) or (IIa) via hydrogenation under pressure with an appropriately chosen hydrogenation catalyst in an suitable organic solvent. (b) making the resulting crude mixture of diastereomeric palonosetrons (VIII) or (VIIIa) contaminated with varying amounts of unconverted intermediate (II) or (IIa) substantially free from (II) or (IIa) via halogenation reaction.

Abstract: The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

Abstract: A network comprising a component configured to update an active set (AS) of cells based on a collective consideration of a plurality of cell measurement reports received during radio reconfiguration. Also included is a user equipment (UE), comprising a component configured such that the UE combines a plurality of cell measurement reports triggered briefly before and/or during radio reconfiguration, the combined measurement report used to update an AS of cells. Also included is a method comprising transmitting a radio bearer reconfiguration message, receiving a plurality of cell measurement reports, receiving a radio bearer reconfiguration complete message, and updating a plurality of AS cells using the combined cell measurement reports. Also included is a method comprising receiving a radio bearer reconfiguration message, obtaining a plurality of cell measurement reports, and sending a combined cell measurement report based on the cell measurement reports.

Abstract: Sewage sludge is dewatered to a cake-like state. The viscosity of the sludge is lowered by admixing a quantity of urea, urea-ammonium-nitrate, or other nitrogen-containing material, in with the dewatered sludge. The treatment also removes pathogens, and renders the product suitable for use as a fertilizer.

Abstract: Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

Abstract: Already-treated sludge is fed back into incoming sewage, and is effective to supply nutrients needed for the microbiological breakdown of the sludge. The feedback sludge has a solids content of 10% or more, and has been sheared and heated to drive its viscosity down to 10,000 cP or less. In sludge done that way, nutrients are preserved and presented to the sewage to be treated in highly liquidized and solubilized form, whereby the nutrients are very bio-available to the microbes in the sewage. Large improvements in the elimination of biomass can result.

Abstract: Provided are compounds that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

Abstract: Provided are compounds having the Formula I or salts thereof, wherein R2, L, R3, R11, D2 and R13 are as defined herein, that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

Abstract: Already-treated sludge is fed back into incoming sewage, and is effective to supply nutrients needed for the microbiological breakdown of the sludge. The feedback sludge has a solids content of 10% or more, and has been sheared and heated to drive its viscosity down to 10,000 cP or less. In sludge done that way, nutrients are preserved and presented to the sewage to be treated in highly liquidised and solubilised form, whereby the nutrients are very bio-available to the microbes in the sewage. Large improvements in the elimination of biomass can result.

Abstract: An improved, scalable, and environmentally friendly manufacturing procedure for the preparation of E-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde, which is a key early intermediate used in the preparation of montelukast sodium, and the compound prepared by such a process.

Abstract: A network storage server receives multiple write requests from a set of clients via a network and internally buffers multiple data blocks written by the write requests. At a consistency point, the storage server commits the data blocks to a nonvolatile mass storage facility. The consistency point process includes using a storage operating system in the network storage server to compress the data blocks, encrypt selected data blocks, and store the compressed and (possibly) encrypted data blocks in the nonvolatile mass storage facility. Data blocks can also be fingerprinted in parallel with compression and/or encryption, to facilitate subsequent deduplication. Data blocks can be indexed and classified according to content or attributes of the data. Encryption can be applied at different levels of logical container granularity, where a separate, unique cryptographic key is used for each encrypted logical container.

Abstract: Provided are compounds of formula I wherein R2, L, Z, Y, G and R1 are as defined herein, that are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

Abstract: Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes meilitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

Abstract: When liquefying sludge, e.g as in U.S. Pat. No. 6,808,636, the combination of temperature, pH, and shearing, is synergistic. Described here is a system that provides for collating test sampling and full-scale data inputs, recording achieved results and the engineering parameters that achieved those particular results. The data is presented in e.g a table format, which assists design engineers to zero-in on the combinations of parameters that will likely give the desired results.

Abstract: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzoazepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is -C?C-R10, -O-R12, -S-R14, or -NR24R25; and other substituents are as defined in the specification.

Abstract: Sewage sludge that has been de-watered to 25% solids is subjected to a combination of shearing and heating that liquefies the sludge, and drops its viscosity to below 12,000 cP. The fact of liquefaction prepares the sludge such that subsequent drying can be done more cost-effectively than hitherto. After drying, the dried sludge can be incinerated.

Abstract: A mobile station is provided. The mobile station includes a processor programmed to promote sending a classmark change message responsive to receiving a command from a network, wherein the command requires a capability that the mobile station does not possess.

Abstract: The present invention relates to certain substituted phenyl oxazolidinones of formula I and H and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

Abstract: Method of preparing an itinerary for a customer traveling to a destination. The method includes the steps of providing on the itinerary reservation information identifying the customer's schedule in relation to at least one of an accommodation, means of transport, and event and providing on the itinerary a listing of merchants local to a destination related to the customer's reservation information. The listed merchants are determined based on their relevance to at least one of the customer's past spending habits and the past spending habits of a group of other customers deemed similar to the customer.

Abstract: Estimating bandwidth of a transport connection from higher layers. In an embodiment, the bandwidth is estimated as a function of the window size, the time taken to transfer a transport payload of window size from the sender system to the receiver system, and a conclusion indicating whether the window size is limited by the network or by the resources on the receiver system. All the factors used in the bandwidth computation are determined based on round-trip times of transport payloads of different sizes transferred between the sender system and the receiver system.