Patents by Inventor Ajay Vaghasia

Ajay Vaghasia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDUCTION OF SYNTHETIC LETHALITY WITH EPIGENETIC THERAPY
    Publication number: 20230100402
    Abstract: The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed herein are screening methods for identifying compounds that induce killing of cancer cells when combined with at least one epigenetic compound. Further disclosed herein are methods of potentiating a therapeutic effect of a chemotherapeutic agent against a cancer, comprising administering to a subject having the cancer an epigenetic compound in an amount effective to potentiate the therapeutic effect of the chemotherapeutic agent against the cancer.
    Type: Application
    Filed: September 16, 2022
    Publication date: March 30, 2023
    Inventors: Srinivasan Yegnasubramanian, William G. Nelson, Ajay Vaghasia, Philipp Nuhn
  • Induction of synthetic lethality with epigenetic therapy
    Patent number: 11491174
    Abstract: The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed herein are screening methods for identifying compounds that induce killing of cancer cells when combined with at least one epigenetic compound. Further disclosed herein are methods of potentiating a therapeutic effect of a chemotherapeutic agent against a cancer, comprising administering to a subject having the cancer an epigenetic compound in an amount effective to potentiate the therapeutic effect of the chemotherapeutic agent against the cancer.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: November 8, 2022
    Assignee: The Johns Hopkins University
    Inventors: Srinivasan Yegnasubramanian, William G. Nelson, Ajay Vaghasia, Philipp Nuhn
  • INDUCTION OF SYNTHETIC LETHALITY WITH EPIGENETIC THERAPY
    Publication number: 20210106603
    Abstract: The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed herein are screening methods for identifying compounds that induce killing of cancer cells when combined with at least one epigenetic compound. Further disclosed herein are methods of potentiating a therapeutic effect of a chemotherapeutic agent against a cancer, comprising administering to a subject having the cancer an epigenetic compound in an amount effective to potentiate the therapeutic effect of the chemotherapeutic agent against the cancer.
    Type: Application
    Filed: June 6, 2018
    Publication date: April 15, 2021
    Inventors: Srinivasan Yegnasubramanian, William G. Nelson, Ajay Vaghasia, Philipp Nuhn