Patents by Inventor Ajay Verma
Ajay Verma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230270674Abstract: The present disclosure relates compartmental administration of modified extracellular vesicles, e.g., exosomes. In some aspects, the extracellular vesicle, e.g., exosome, comprises a biologically active molecule and a targeting moiety.Type: ApplicationFiled: March 15, 2021Publication date: August 31, 2023Applicant: Codiak BioSciences, Inc.Inventors: Ajay VERMA, Wei ZHANG, Ke XU, Shailendra PATEL
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Publication number: 20230241089Abstract: Abstract: Provided herein are compositions comprising EV, e.g., exosome, which comprises STING agonists and methods of using such compositions for the treatment of neuroimmunological disorders. Methods of producing the compositions (e.g., EVs comprising a STING agonist) described herein are also provided.Type: ApplicationFiled: September 24, 2020Publication date: August 3, 2023Applicant: Codiak BioSciences, Inc.Inventor: Ajay VERMA
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Publication number: 20230220068Abstract: The present disclosure relates extracellular vesicles, e.g., exosomes, comprising an antigen-binding moeity, e.g., a single-domain antigen-binding moeity, e.g., a vNAR, a VHH, or a fragment thereof, that specifically binds transferrin receptor, and methods of making and using the same.Type: ApplicationFiled: June 7, 2021Publication date: July 13, 2023Applicant: Codiak BioSciences, Inc.Inventors: Ajay VERMA, Leonid GAYDUKOV, Ke XU, Kevin P. DOOLEY, Jonathan FINN
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Patent number: 11660054Abstract: Embodiments related to methods and wearable medical detecting systems for detecting disease states and/or treatment states of a subject are described. In one embodiment, a wearable structure may include one or more radiation detectors use to detect a time varying radiation signal emitted from a labeled compound within a body portion of interest. The radiation signal may be analyzed to determine one or more signal characteristics that may be compared to one or more predetermined standard characteristics associated with known disease and/or treatment states to determine a current disease and/or treatment state of a subject.Type: GrantFiled: November 22, 2017Date of Patent: May 30, 2023Assignee: Biogen MA Inc.Inventors: Ajay Verma, Elliot Greenblatt, Ira Spool, Seth O. Newburg, Guy M. Danner, Ara N. Knaian, Rachel M. Chaney, John W. Hoppin
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Publication number: 20230132093Abstract: The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an NLRP3 antagonist. In some aspects, the NLRP3 antagonist comprises an antisense oligonucleotide (ASO). Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.Type: ApplicationFiled: August 14, 2020Publication date: April 27, 2023Applicant: Codiak BioSciences, Inc.Inventors: Joanne LIM, Katherine KIRWIN, Wendy BROOM, Sriram SATHYANARAYANAN, Ajay VERMA
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Publication number: 20230124136Abstract: Various embodiments described herein relate to a virtual network with a cloud-based server, cloud-based firewall and a cloud-based service. The cloud-based server is in communication with a client installed on a gateway to receive an encapsulated IP data packet from one or more applications installed on the gateway. The cloud-based configured to decapsulate the encapsulated IP data packet verify a security certificate based on a first information and configure a cloud-based firewall based on a second information. The cloud-based server is configured to route the one or more IP data packets to the cloud-based firewall for processing each IP data packet based on the second information. In response to the one or more IP data packets being compliant with the first information provided to authenticate the gateway and the second information provided to configure the cloud-based firewall, routing the one or more IP data packets to the cloud-based service.Type: ApplicationFiled: October 7, 2022Publication date: April 20, 2023Applicant: Honeywell International Inc.Inventors: Ajay VERMA, Amod KAMAT, William B. SMITH, IV, Daniel P. GIORGIS, Hugh L. EAVES, Michael P. SMITH, Patrick SAGER, Upender PARAVASTU
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Publication number: 20230114434Abstract: The present disclosure relates to extracellular vesicles (EVs) that are capable of targeting a cell in the CNS of a subject. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders of the CNS (e.g., neurological disorders).Type: ApplicationFiled: March 15, 2021Publication date: April 13, 2023Applicant: Codiak BioSciences, Inc.Inventors: Ajay VERMA, Tim SOOS, Nikki ROSS, Christine MCCOY, Jonathan FINN, Sriram SATHYANARAYANAN, Shailendra PATEL, Ke XU, Russell E. MCCONNELL, Kevin P. DOOLEY
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Publication number: 20230002764Abstract: The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), wherein the ASO comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length that is complementary to a nucleic acid sequence within a CEBP/transcript. Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.Type: ApplicationFiled: August 14, 2020Publication date: January 5, 2023Applicant: Codiak BioSciences, Inc.Inventors: Dalia BURZYN, Sushrut KAMERKAR, Adam T. BOUTIN, Wendy BROOM, Sriram SATHYANARAYANAN, Ajay VERMA
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Patent number: 11517743Abstract: Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.Type: GrantFiled: September 29, 2020Date of Patent: December 6, 2022Assignee: Apex Neuro Holdings, Inc.Inventors: Zen Chu, Miles Thibault, Kelsey Fafara, Francois Kress, Rohan Ajay Verma, Alyssa Boasso, Sean Hagberg, Julia Brock
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Patent number: 11504521Abstract: Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.Type: GrantFiled: January 7, 2019Date of Patent: November 22, 2022Assignee: Apex Neuro Holdings, Inc.Inventors: Zen Chu, Miles Thibault, Kelsey Fafara, Francois Kress, Rohan Ajay Verma, Alyssa Boasso, Sean Hagberg, Julia Brock
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Patent number: 11484278Abstract: Wearable apparatus and method of using same for tracking a labeled probe in a subject are disclosed.Type: GrantFiled: March 12, 2014Date of Patent: November 1, 2022Assignee: Biogen MA Inc.Inventors: Ajay Verma, Jack Hoppin, Jacob Hesterman
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Publication number: 20210347866Abstract: The present disclosure is directed to dipeptide repeat (DPR) peptide immunogen constructs, compositions containing the constructs, antibodies elicited by the constructs, and methods for making and using the constructs and compositions thereof. The disclosed DPR peptide immunogen constructs contain a B cell epitope derived from a DPR protein from C9orf72, including repeats of poly-GA, poly-GP, poly-GR, poly-PR, and poly-PA, linked to a heterologous T helper cell (Th) epitope directly or through an optional heterologous spacer. The B cell epitope portion of the peptide immunogen constructs contain about 10 to about 25 repeats of the respective dipeptide sequence. The disclosed peptide immunogen constructs stimulate the generation of highly specific antibodies directed against the DPR sequences.Type: ApplicationFiled: October 1, 2019Publication date: November 11, 2021Inventors: Chang Yi WANG, Ajay VERMA
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Patent number: 11147524Abstract: Various embodiments of medical detector systems as well as their methods of operation are disclosed. In one embodiment, one or more detectors are coupled to wearable structures for detecting at least a first tracer within a body portion. In another embodiment, one or more detectors are coupled to a wearable structure, where the detector corresponds to a CMOS chip that directly detects a first radioactive tracer.Type: GrantFiled: December 21, 2018Date of Patent: October 19, 2021Assignee: Biogen MA Inc.Inventors: Ajay Verma, Marisa J. Bober, Victoria Cabot, Courtney D. Hilliard, Ara N. Knaian, Seth O. Newburg, John William Hoppin, Karl F. Schmidt
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Patent number: 11040119Abstract: The invention provides compositions and methods for evaluating neuromuscular function in a subject, e.g., a subject at risk for or suffering from a neuromuscular disorder.Type: GrantFiled: March 12, 2014Date of Patent: June 22, 2021Assignee: Biogen MA Inc.Inventors: Ajay Verma, Jack Hoppin
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Patent number: 10945951Abstract: Methods and apparatuses for dispersing a compound within the patient are described. In one embodiment, an effective amount of a compound may be present in the cerebrospinal fluid of a patient and a force may be applied to the torso of the patient sufficient to enhance the convection of the cerebrospinal fluid. In another embodiment, a bolus including a compound may be injected into the cerebrospinal fluid of a patient. The volume of the bolus may be between about 5% and 30% of the total volume of the cerebrospinal fluid of the patient.Type: GrantFiled: December 17, 2015Date of Patent: March 16, 2021Assignee: Biogen MA Inc.Inventor: Ajay Verma
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Publication number: 20210060330Abstract: Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.Type: ApplicationFiled: September 29, 2020Publication date: March 4, 2021Inventors: Zen Chu, Miles Thibault, Kelsey Fafara, Francois Kress, Rohan Ajay Verma, Alyssa Boasso, Sean Hagberg, Julia Brock
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Patent number: 10786666Abstract: Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.Type: GrantFiled: October 18, 2019Date of Patent: September 29, 2020Assignee: Apex Neuro Holdings Inc.Inventors: Zen Chu, Miles Thibault, Kelsey Fafara, Francois Kress, Rohan Ajay Verma, Alyssa Boasso, Sean Hagberg, Julia Brock
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Publication number: 20200054873Abstract: Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.Type: ApplicationFiled: October 18, 2019Publication date: February 20, 2020Inventors: Zen Chu, Miles Thibault, Kelsey Fafara, Francois Kress, Rohan Ajay Verma, Alyssa Boasso, Sean Hagberg, Julia Brock
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Publication number: 20190320989Abstract: Embodiments related to methods and wearable medical detecting systems for detecting disease states and/or treatment states of a subject are described. In one embodiment, a wearable structure may include one or more radiation detectors use to detect a time varying radiation signal emitted from a labeled compound within a body portion of interest. The radiation signal may be analyzed to determine one or more signal characteristics that may be compared to one or more predetermined standard characteristics associated with known disease and/or treatment states to determine a current disease and/or treatment state of a subject.Type: ApplicationFiled: November 22, 2017Publication date: October 24, 2019Applicant: Biogen MA Inc.Inventors: Ajay Verma, Elliot Greenblatt, Ira Spool, Seth O. Newburg, Guy M. Danner, Ara N. Knaian, Rachel M. Chaney
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Publication number: 20190232046Abstract: Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.Type: ApplicationFiled: January 7, 2019Publication date: August 1, 2019Inventors: Zen Chu, Miles Thibault, Kelsey Fafara, Francois Kress, Rohan Ajay Verma, Alyssa Boasso, Sean Hagberg