Patents by Inventor Ajaya Kumar Reka

Ajaya Kumar Reka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOPICAL FORMULATIONS OF (1S)-1-PHENYL-2-PYRIDIN-2-YLETHANAMINE
    Publication number: 20230190719
    Abstract: Provided is a pharmaceutical formulation including (1S)-1-phenyl-2-pyridin-2-ylethanamine, a pharmaceutically acceptable salt thereof, a solvate thereof, or a prodrug thereof; and a pharmaceutically acceptable topical carrier. Also provided is a method for treating neuropathic pain by administering to a patient in need of such treatment a therapeutically effective amount of the pharmaceutical formulation.
    Type: Application
    Filed: June 23, 2021
    Publication date: June 22, 2023
    Inventors: Robert BERMAN, Rajesh KUMAR, Charles M. CONWAY, Mary K. DONOHUE, Ajaya Kumar REKA
  • 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin and its preparation and use for the treatment of cancer
    Patent number: 8080559
    Abstract: A 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2?-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: December 20, 2011
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Venkateswarlu Akella, Shanavas Alikunju, Ajaya Kumar Reka, Ramesh Mullangi, Raju Sirisilla, Subrahmanyam Duvvuri, Sriram Rajagopal
  • 5(S)-(2'-HYDROXYETHOXY)-20(S)-CAMPTOTHECIN AND ITS PREPARATION AND USE FOR THE TREATMENT OF CANCER
    Publication number: 20100063083
    Abstract: A 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2?-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
    Type: Application
    Filed: October 12, 2009
    Publication date: March 11, 2010
    Applicant: Dr. Reddy's Laboratories LTD.
    Inventors: Venkateswarlu Akella, Shanavas Alikunju, Ajaya Kumar Reka, Ramesh Mullangi, Raju Sirisilla, Subrahmanyam Duvvuri, Sriram Rajagopal
  • 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin and its preparation and use for the treatment of cancer
    Patent number: 7601733
    Abstract: A 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2?-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: October 13, 2009
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Venkateswarlu Akella, Shanavas Alikunju, Ajaya Kumar Reka, Ramesh Mullangi, Raju Sirisilla, Subrahmanyam Duvvuri, Sriram Rajagopal
  • Crystalline form of 5(S)-(2-hydroxyethoxy)-20(S)-camptothecin
    Patent number: 7601732
    Abstract: A crystalline form of 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer of 5(RS)-(2?-hydroxyethoxy)-20(S)-camptothecin is described that is characterized by having an X-ray powder diffraction pattern comprising one or more peak intensities expressed in degrees 2? that are selected from the group consisting of 7.2±0.1, 9.4±0.1, 11.02±0.1, 12.00±0.1, 14.54±0.1, 15.2±0.1, 18.92±0.1, 21.86±0.1, 22.74±0.1 and 26.42±0.1. Methods of making and using the compound are also described.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: October 13, 2009
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Venkateswarlu Akella, Shanavas Alikunju, Ajaya Kumar Reka, Ramesh Mullangi, Raju Sirisilla, Subrahmanyam Duvvuri, Sriram Rajagopal