Patents by Inventor Ajish GEORGE
Ajish GEORGE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9719085Abstract: Disclosed are RNA constructs which function to activate or inactivate a biological process, e.g., may be designed for attachment to a polypeptide coding region. Such RNA constructs modulate translation of a polypeptide from the coding region in response to the presence of a target polynucleotide in an expression environment. Such RNA constructs include a weakened stem-loop structure which, when bound to the target polynucleotide, assumes stem-loop secondary structure and associates with an RNA binding protein. Association with the RNA binding protein modulates translation of the polypeptide coding region. Such RNA constructs also have three-way junction joining regions 3? and 5? of the stem-loop structure.Type: GrantFiled: August 20, 2014Date of Patent: August 1, 2017Assignee: The Research Foundation of the University of New YorkInventors: Scott A. Tenenbaum, Francis J. Doyle, II, Ajish George, Christopher Zaleski
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Publication number: 20150045414Abstract: Disclosed are RNA constructs which function to activate or inactivate a biological process, e.g., may be designed for attachment to a polypeptide coding region. Such RNA constructs modulate translation of a polypeptide from the coding region in response to the presence of a target polynucleotide in an expression environment. Such RNA constructs include a weakened stem-loop structure which, when bound to the target polynucleotide, assumes stem-loop secondary structure and associates with an RNA binding protein. Association with the RNA binding protein modulates translation of the polypeptide coding region. Such RNA constructs also have three-way junction joining regions 3? and 5? of the stem-loop structure.Type: ApplicationFiled: August 20, 2014Publication date: February 12, 2015Inventors: Scott A. Tenenbaum, Francis J. Doyle, II, Ajish George, Christopher Zaleski
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Patent number: 8841438Abstract: Disclosed are RNA constructs which function to activate or inactivate a biological process, e.g., may be designed for attachment to a polypeptide coding region. Such RNA constructs modulate translation of a polypeptide from the coding region in response to the presence of a target polynucleotide in an expression environment. Such RNA constructs include a weakened stem-loop structure which, when bound to the target polynucleotide, assumes stem-loop secondary structure and associates with an RNA binding protein. Association with the RNA binding protein modulates translation of the polypeptide coding region. Such RNA constructs also have three-way junction joining regions 3? and 5? of the stem-loop structure.Type: GrantFiled: May 21, 2010Date of Patent: September 23, 2014Assignee: The Research Foundation of the University of New YorkInventors: Scott A. Tenenbaum, Francis J. Doyle, II, Ajish George, Christopher Zaleski
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Publication number: 20120252876Abstract: Disclosed are RNA constructs which function to activate or inactivate a biological process, e.g., may be designed for attachment to a polypeptide coding region. Such RNA constructs modulate translation of a polypeptide from the coding region in response to the presence of a target polynucleotide in an expression environment. Such RNA constructs include a weakened stem-loop structure which, when bound to the target polynucleotide, assumes stem-loop secondary structure and associates with an RNA binding protein. Association with the RNA binding protein modulates translation of the polypeptide coding region. Such RNA constructs also have three-way junction joining regions 3? and 5? of the stem-loop structure.Type: ApplicationFiled: May 21, 2010Publication date: October 4, 2012Inventors: Scott A. Tenenbaum, Francis J. Doyle, II, Ajish George, Christopher Zaleski
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Publication number: 20080281530Abstract: Processing of genomic data is provided utilizing correlation analysis of first and second nucleotide loci employing a selected comparison type and value. The comparison type is either intersection or proximity type, and the comparison value is either a number (n) of nucleotide positions, wherein n?1, or a percent number (pn) of nucleotide positions, wherein pn?0, to be employed in comparing the loci. When intersection type is selected, correlation is defined by the loci overlapping with at least the number (n) of nucleotide positions in common, or by the loci overlapping with at least the percent number (pn) of nucleotide positions in common relative to a smaller one of the first and second loci, or when proximity type is selected, correlation is defined by the first and second loci being within at least the number (n) of nucleotide positions.Type: ApplicationFiled: February 5, 2008Publication date: November 13, 2008Applicant: The Research Foundation of State University of New YorkInventors: Scott A. TENENBAUM, Christopher ZALESKI, Francis DOYLE, Ajish GEORGE
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Publication number: 20080281819Abstract: Processing of genomic data is facilitated by providing a control data set generation system wherein a control generator tool or process creates matched data sets for facilitating informatics analysis. These matched data sets may include genomic loci or genomic sequences, or both. The data is taken from a database of actual genomic data, including sequence and annotation data, as opposed to ad-hoc generation, sequence scrambling or the like. This produces biologically relevant and accurate results which allow for stronger controls. The controls are matched against a user-provided data set via a number of parameters.Type: ApplicationFiled: February 5, 2008Publication date: November 13, 2008Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORKInventors: Scott A. TENENBAUM, Christopher ZALESKI, Francis DOYLE, Ajish GEORGE
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Publication number: 20080281818Abstract: Processing of genomic data is facilitated by providing a storage device with a database having a segmented sequence table. The table has a plurality of data subsets of common nucleotide sequence size n, wherein?2, and each data subset of common nucleotide sequence n is separately indexed within the table. A database manager associated with the database retrieves a selected nucleotide sequence locus from the table. The selected nucleotide sequence locus is sized differently from the common nucleotide sequence size n, and the retrieving includes identifying each data subset of the segmented sequence table containing at least a portion of the selected nucleotide sequence locus, and retrieving the identified data subsets. The database manager processes the retrieved, identified data subsets to remove genomic data mapped to the nucleotide positions outside the selected nucleotide sequence locus, and outputs the selected nucleotide sequence locus.Type: ApplicationFiled: February 5, 2008Publication date: November 13, 2008Applicant: The Research Foundation of State University of New YorkInventors: Scott A. TENENBAUM, Christopher ZALESKI, Francis DOYLE, Ajish GEORGE
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Publication number: 20080281529Abstract: Processing of genomic data is facilitated utilizing correlation analysis of mapped data sets, each data set including genomic data mapped and ordered relative to a genomic coordinate system. Correlation analysis identifies at a nucleotide level nucleotide positions wherein at least one nucleotide locus of each data set correlate. The analysis includes for each data set, selecting a nucleotide locus thereof closest to one end of the coordinate system, comparing the selected nucleotide loci for correlation, and if so, outputting results of the comparing, and updating the selected nucleotide loci by identifying the data set having a next nucleotide locus closest to the one end of the coordinate system, and inserting that next locus into the group of selected loci, and repeating the comparing for the newly selected loci. The process is repeated until nucleotide loci of the mapped data sets are compared and results of the comparison are output.Type: ApplicationFiled: February 5, 2008Publication date: November 13, 2008Applicant: The Research Foundation of State University of New YorkInventors: Scott A. TENENBAUM, Christopher ZALESKI, Francis DOYLE, Ajish GEORGE