Patents by Inventor Ajit Kumar Saxena

Ajit Kumar Saxena has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9206201
    Abstract: Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: December 8, 2015
    Assignee: Counsel of Scientific & Industrial Research
    Inventors: Ram Asrey Vishwakarma, Sanghapal Damodhar Sawant, Parvinder Pal Singh, Abid Hamid Dar, Parduman Raj Sharma, Ajit Kumar Saxena, Amit Nargotra, Anjaneya Aravind Kumar Kolluru, Ramesh Mudududdla, Asif Khurshid Qazi, Aashiq Hussain, Nayan Chanauria
  • Patent number: 9029553
    Abstract: The present invention provides compounds of general formula A useful as potential anticancer agents against human cancer cell lines and apoptosis inducers. The present invention further provides a process for the preparation of 2-anilino nicotinyl linked 2-amino benzothiazole conjugates of general formula (A), wherein R1?H or Cl; R2?H, OCH3 or F; R3?H, OCH3, F or Cl; R4?H, OCH3 or F and X?OCH3, F or N02.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: May 12, 2015
    Assignee: Council of Scientific & Industrial Research
    Inventors: Ahmed Kamal, Yellamelli Valli Venkata Srikanth, Mohammed Naseer Ahmed Khan, Mohammed Ashraf, Irum Sehar, Gousia Chashoo, Parduman Raj Sharma, Abid Hamid Dar, Bhushan Shashi, Shashank Kumar Singh, Dilip Manikrao Mondhe, Ajit Kumar Saxena
  • Publication number: 20150051173
    Abstract: Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 19, 2015
    Inventors: Ram Asrey Vishwakarma, Sanghapal Damodhar Sawant, Parvinder Pal Singh, Abid Hamid Dar, Parduman Raj Sharma, Ajit Kumar Saxena, Amit Nargotra, Anjaneya Aravind Kumar Kolluru, Ramesh Mudududdla, Asif Khurshid Qazi, Aashiq Hussain, Nayan Chanauria
  • Patent number: 8921552
    Abstract: Compounds of general formula A useful as potential anticancer agents against human cancer cell lines and a process for the preparation thereof.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: December 30, 2014
    Assignee: Council of Scientific & Industrial Research
    Inventors: Ahmed Kamal, Adla Mallareddy, Paidakula Suresh, Rajesh V. C. R. N. C. Shetti, Harish Chandra Pal, Ajit Kumar Saxena
  • Patent number: 8841466
    Abstract: This invention relates to the synthesis of certain novel Baylis-Hillman adducts of artremisinin derived aldehyde 2-[10??-deoxoartemisininyl]-ethanal. The capabilities of introduction of three functional groups into a molecule in one step using Baylis-Hillman reaction encouraged us to synthesize some highly functionalized derivatives of artemisinin. These highly functionalized artemisinin derivatives embodied in this document are found to be active against various cancer cell-lines.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: September 23, 2014
    Assignee: Council of Scientific & Industrial Research
    Inventors: Gakul Baishya, Nabin Chandra Barua, Abhishek Goswami, Partha Pratim Saikia, Paruchuri Gangadhar Rao, Ajit Kumar Saxena, Nitasha Suri, Madhunika Sharma
  • Publication number: 20140039190
    Abstract: Compounds of general formula A useful as potential anticancer agents against human cancer cell lines and a process for the preparation thereof.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 6, 2014
    Inventors: Ahmed Kamal, Adla Mallareddy, Paidakula Suresh, Rajesh V., C., R., N., C. Shetti, Harish Chandra Pal, Ajit Kumar Saxena
  • Patent number: 8633242
    Abstract: The present invention relates to benzylidene indanones of general formula 1. The compounds exhibited tubulin polymerisation inhibition. A series of compounds 2-benzylidene 3-(3,4,5-trimethoxyphenyl) indanones having general formula 1 were synthesized from gallic acid through a chemical process. 2-(3,4-Methylenedioxybenzylidine), 3-(3,4,5-trimethoxyphenyl), 4,5,6-trimethoxyindanone (8), a representative compound of this series possessing the molecular formula C29H28O9, was synthesized from gallic acid and exhibits potent anticancer activity. Compound 8 was evaluated for acute oral activity in Swiss albino mice and found to be safe up to 300 mg/kg body weight. The anticancer activity of the compounds has been determined, in order to obtain new potent and cost effective molecules using an in vitro cytotoxicity assay.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: January 21, 2014
    Assignee: Council of Scientific and Industrial Research
    Inventors: Arvind Singh Negi, Ayyampudur Palanisamy Prakasham, Ajit Kumar Saxena, Suaib Luqman, Debabrata Chanda, Tandeep Kaur, Atul Gupta
  • Patent number: 8609858
    Abstract: The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides, nitrones, azides, nitrile ylide diazoalkane, nitrile imide, ozone, azomethine imides, azomethine ylides etc. with exocyclic double bond of C ring (?-methylene-?-butyrolactone). Representative compounds have been screened for their anticancer activity against different cancer cell lines. ICs0 value of these analogues varies between 4.3 ?M to 93 ?M. A mechanistic correlation of their anticancer activity has been described. The results of the cytotoxicity test of the compounds studies indicated that the ?,?-unsaturated ketonic moiety in parthenin plays an important role in the maintenance of the high level of cytotoxicity.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: December 17, 2013
    Assignee: Council of Scientific & Industrial Research
    Inventors: Mahabalarao Sampath Kumar Halmuthur, Ajit Kumar Saxena, Subhash Chandra Taneja, Shashank Kumar Singh, Vijay Kumar Sethi, Naveed Ahmed Qazi, Sanghapal Damodhar Sawant, Mahendhar Reddy Doma, Abid Hussain Banday, Monika Verma, Ghularn Nabi Qazi
  • Publication number: 20130331581
    Abstract: The present invention relates to 1,2,3-triazole containing artemisinin compounds and process for preparation thereof. Described herein is the synthesis, bioassay results and usefulness of the artemisinin derived compounds resulting from 1,3-di-polar cycloaddition reaction of artemisinin derived azide or alkyne with aliphatic or aromatic diazides. These 1,2,3-triazole containing artemisinin derived compounds embodied in this document are found to be active against various cancer cell-lines.
    Type: Application
    Filed: February 14, 2012
    Publication date: December 12, 2013
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Bishwajit Saikia, Nabin Chandra Barua, Partha Pratim Saikia, Abhishek Goswami, Paruchuri Gangadhar Rao, Ajit Kumar Saxena, Nitasha Suri
  • Publication number: 20130324734
    Abstract: The present invention provides compounds of general formula A useful as potential anticancer agents against human cancer cell lines and apoptosis inducers. The present invention further provides a process for the preparation of 2-anilino nicotinyl linked 2-amino benzothiazole conjugates of general formula (A), wherein R1?H or CI; R2?H, OCH3 or F; R3?H, OCH3, F or CI; R4?H, OCH3 or F and X?OCH3, F or N02.
    Type: Application
    Filed: March 30, 2011
    Publication date: December 5, 2013
    Inventors: Ahmed Kamal, Yellamelli Valli Venkata Srikanth, Mohammed Naseer Ahmed Khan, Mohammed Ashraf, Irum Sehar, Gousia Chashoo, Parduman Raj Sharma, Abid Hamid Dar, Bhushan Shashi, Shashank Kumar Singh, Dilip Manikrao Mondhe, Ajit Kumar Saxena
  • Publication number: 20130030044
    Abstract: This invention relates to the synthesis of certain novel Baylis-Hillman adducts of artremisinin derived aldehyde 2[10??-deoxoartemisininyl]-ethanal. The capabilities of introduction of three functional groups into a molecule in one step using Baylis-Hillman reaction encouraged us to synthesize some highly functionalized derivatives of artemisinin.
    Type: Application
    Filed: January 20, 2011
    Publication date: January 31, 2013
    Applicant: Council of Scientific & Industrial Research
    Inventors: Gakul Baishya, Nabin Chandra Barua, Abhishek Goswami, Partha Pratim Saikia, Paruchuri Gangadhar Rao, Ajit Kumar Saxena, Nitasha Suri, Madhunika Sharma
  • Publication number: 20110201661
    Abstract: The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides, nitrones, azides, nitrile ylide diazoalkane, nitrile imide, ozone, azomethine imides, azomethine ylides etc. with exocyclic double bond of C ring (?-methylene-?-butyrolactone). Representative compounds have been screened for their anticancer activity against different cancer cell lines. ICs0 value of these analogues varies between 4.3 ?M to 93 ?M. A mechanistic correlation of their anticancer activity has been described. The results of the cytotoxicity test of the compounds studies indicated that the ?,?-unsaturated ketonic moiety in parthenin plays an important role in the maintenance of the high level of cytotoxicity.
    Type: Application
    Filed: March 5, 2009
    Publication date: August 18, 2011
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Mahabalarao Sampath Kumar Halmuthur, Ajit Kumar Saxena, Subhash Chandra Taneja, Shashank Kumar Singh, Vijay Kumar Sethi, Naveed Ahmed Qazi, Sanghapal Damodhar Sawant, Mahendhar Reddy Doma, Abid Hussain Banday, Monika Verma, Ghularn Nabi Qazi
  • Publication number: 20090298938
    Abstract: The present invention relates to use of compounds of general formula 1 for anticancerous activity, wherein the said compound being derived semi-synthetically from natural triterpenoic acids known as boswellic acids by the induction of apoptosis thereof cytotoxicity and anti-cancer activity displayed by semi-synthetic analogues of natural triterpenes, known as Boswellic acids. These compounds may be used for the treatment of cancer, alone or in combination with pharmaceutically acceptable or other carriers, displaying cytotoxicity and anti-cancer activity for colon, prostrate, liver, breast, central nervous system (CNS), leukemia and malignancy of other tissues, including ascites and solid tumors. The cancer cell death is mediated by induction of apoptosis and inhibition of cell proliferation at specific doses.
    Type: Application
    Filed: March 10, 2009
    Publication date: December 3, 2009
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Ghulam Nabi Qazi, Subhash Chandra Taneja, Jaswant Singh, Ajit Kumar Saxena, Vijay Kumar Sethi, Bhahwal Ali Shah, Bal Krishan Kapahi, Samar Singh Andotra, Ajay Kumar, Shashi Bhushan, Fayaz Malik, Dilip Manikrao Mondhe, Shanmugavel Muthiah, Surjeet Singh, Monika Verma, Shashank Kumar Singh
  • Patent number: 7378268
    Abstract: The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis of Camptothecin (camptothecinoids).
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: May 27, 2008
    Assignee: Council Of Scientific & Industrial Research
    Inventors: Satish Chander Puri, Vijeshwar Verma, Touseef Amna, Geeta Handa, Vinay Gupta, Neelam Verma, Ravi Kant Khajuria, Ajit Kumar Saxena, Ghulam Nabi Qazi, Michael Spiteller
  • Patent number: 7285571
    Abstract: The present invention relate to a novel synergistic composition of lignans exhibiting anticancer activities for breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate cancer obtained from the plant extract of Cedrus deodra, said composition comprising of (?)-Matairesinol in the range of 9 to 13% by weight, (?)-Wikstromol in the range of 75 to 79% by weight, Dibenzylbutyrolactol in the range of 7 to 11% by weight, and Unidentified material in the range of 2.6 to 3% by weight; further, the synergistic composition of lignan is used in combination with pharmaceutically acceptable carriers for inhibiting growth of various human cancer cell lines selected from breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate tissues.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: October 23, 2007
    Assignee: Council of Scientific and Industrial Research
    Inventors: Janaswamy Madhusudana Rao, Pullela Venkata Srinivas, Jhillu Singh Yadav, Kondapuram Vijaya Raghavan, Ajit Kumar Saxena, Mutiah Shanmugavel, Himani Kampasi, Gulam Nabi Qazi
  • Patent number: 7118766
    Abstract: The present invention relates to a pharmaceutical composition comprising a bioactive constituent trans-tetracos-15-enoic acid and a process for the isolation of tetracos-15-enoic acid from the plant Indigofera tinctoria along with a method of treatment for hepatotoxicity.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: October 10, 2006
    Assignee: Council of Scientific & Industrial Research
    Inventors: Sukhdev Swami Handa, Bupinder Singh, Bal Krishan Chandan, Ajit Kumar Saxena, Vikram Bhardwaj, V. N. Gupta, Om Parkash Suri, Naresh Kumar Satti, Krishan Avtar Suri
  • Publication number: 20040192777
    Abstract: Two compounds namely ent-pimmarane 8(14),15-diene-19 oic acid (compound 1) and ent-pimmarane 7(8),9(11),15-diene-19 oic acid (compound 2) were isolated from Lavatera cachmeriania, these compounds, in vitro, significantly inhibited the growth of number of human cancer cell lines (CNS : SK-N-MC, Colon : HT-29, Lung : A-549 , Liver: Hep-2, Ovary: OVCAR-5, Prostate: PC-3) representing different organs.
    Type: Application
    Filed: March 28, 2003
    Publication date: September 30, 2004
    Applicants: COUNCIL OF SCIENTIFIC AND INDUSTRIAL, REGIONAL RESEARCH INSTITUTE OF UNANI MEDICINE (Central Council of Research in U.M. New Delhi)
    Inventors: Mohammad Yaseen Dar, Mohammad Yousuf, Mushtaq A. Qurishi, Anees A. Ansari, Shamshad Ahmad, Abdul Sami Shawl, Ajit Kumar Saxena, Gulam Nabi Qazi
  • Patent number: 6649650
    Abstract: The present invention relate to a novel synergistic composition of lignans exhibiting anticancer activities for breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate cancer obtained from the plant extract of Cedrus deodra, said composition comprising of (−)-Matairesinol in the range of 9 to 13% by weight, (−)-Wikstromol in the range of 75 to 79% by weight, Dibenzylbutyrolactol in the range of 7 to 11% by weight, and Unidentified material in the range of 2.6 to 3% by weight; further, the synergistic composition of lignan is used in combination with pharmaceutically acceptable carriers for inhibiting growth of various human cancer cell lines selected from breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate tissues.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: November 18, 2003
    Assignee: Council of Scientific and Industrial Research
    Inventors: Janaswamy Madhusudana Rao, Pullela Venkata Srinivas, Jhillu Singh Yadav, Kondapuram Vijaya Raghavan, Ajit Kumar Saxena, Mutiah Shanmugavek, Himani Kampasi, Gulam Nabi Qazi
  • Publication number: 20030175363
    Abstract: The present invention relates to a pharmaceutical composition comprising a bioactive constituent trans-tetracos-15-enoic acid and a process for the isolation of tetracos-15-enoic acid from the plant Indigofera tinctoria along with a method of treatment for hepatotoxicity.
    Type: Application
    Filed: February 11, 2002
    Publication date: September 18, 2003
    Inventors: Sukhdev Swami Handa, Bupinder Singh, Bal Krishan Chandan, Ajit Kumar Saxena, Vikram Bhardwaj, V.N. Gupta, Om Parkash Suri, Naresh Kumar Satti, Krishan Avtar Suri
  • Patent number: 6548086
    Abstract: Pharmaceutical composition and a method useful for treating immunodeficiency in animals or human beings, said composition comprising effective amount of the extract obtained from any part of plant Cryptolepis buchanani, either as such or its individual constituents singly or in composition with each other, optionally associated with pharmaceutically acceptable additives.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: April 15, 2003
    Assignee: Council of Scientific and Industrial Research
    Inventors: Rakesh Maurya, Anpurna Kaul, Sarang Bani, Usha Zutshi, Anamika Khajuria, Ajit Kumar Saxena, Lila Ram Manahas, Ashwani Kumar, Bal Krishnan Kapahi, Om Parkash Suri, Gulam Nabi Qazi