Abstract: Example embodiments of aspects of the present disclosure provide an example computer-implemented method for improved prompting of a machine-learned model. The example method can include obtaining an instructive sequence descriptive of an instructive query, an instructive response, and an instructive trace of intermediate states from the instructive query to the instructive response. The example method can include inputting, to a machine-learned model, the instructive sequence and an operative query, wherein the machine-learned model is configured to process the operative query with attention over the instructive sequence. The example method can include generating, using the machine-learned model and responsive to the operative query, an operative response.

Abstract: An example method for pretraining a machine-learned model is provided. The example method includes obtaining a plurality of different combinations of configuration parameters of a pretraining objective framework. The example method includes generating, using the pretraining objective framework, a plurality of corrupted training examples from one or more training examples, wherein the plurality of corrupted training examples are respectively generated according to the plurality of different combinations. The example method includes inputting the plurality of corrupted training examples into the machine-learned model, wherein the machine-learned model is configured to generate uncorrupted subportions corresponding to corrupted subportions of the corrupted training examples. The example method includes obtaining, from the machine-learned model, a plurality of outputs respectively generated by the machine-learned model based on the plurality of corrupted training examples.

Abstract: The present invention relates to solid, semisolid, or liquid formulations comprising water soluble antioxidants that prevent or reduce formic acid and/or formyl species generation in the dosage form during the manufacturing process and/or during shelf-life storage. The formulations of the present invention prevent or reduce formation of N-formyl impurities (and gelatin crosslinking) during the manufacturing process and/or during shelf-life storage.

Abstract: The present invention relates to solid, semisolid, or liquid formulations comprising water soluble antioxidants that prevent or reduce formic acid and/or formyl species generation in the dosage form during the manufacturing process and/or during shelf-life storage. The formulations of the present invention prevent or reduce formation of N-formyl impurities (and gelatin cross-linking) during the manufacturing process and/or during shelf-life storage.

Abstract: The present invention is directed to improved oral liquid compositions that include sumatriptan, or a pharmaceutically acceptable salt or metabolite thereof, and a pharmaceutically acceptable carrier that includes a liquid portion of the composition. The compositions are substantially free of oxidation impurities. Typically, the compositions include a sweetening agent and a flavoring agent, or a bitterness-reducing agent and flavoring agent. Processes of preparing such compositions and methods of administering such compositions are also included.