Patents by Inventor Ajit Subramanian

Ajit Subramanian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MDCK cell lines supporting viral growth to high titers and bioreactor process using the same
    Patent number: 8846032
    Abstract: The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: September 30, 2014
    Assignee: MedImmune, LLC
    Inventors: Jonathan Liu, Richard Schwartz, Mark Thompson, Luis Maranga, Mridul Ghosh, Ajit Subramanian, Simon Sheng-Tsiung Hsu
  • Non-tumorigenic MDCK cell line for propagating viruses
    Patent number: 8748174
    Abstract: The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: June 10, 2014
    Assignee: MedImmune, LLC
    Inventors: Richard Schwartz, John Michael Berry, Ajit Subramanian, Xiao Shi
  • MDCK CELL LINES SUPPORTING VIRAL GROWTH TO HIGH TITERS AND BIOREACTOR PROCESS USING THE SAME
    Publication number: 20130052717
    Abstract: The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.
    Type: Application
    Filed: August 27, 2012
    Publication date: February 28, 2013
    Applicant: MEDIMMUNE, LLC
    Inventors: Jonathan LIU, Richard SCHWARTZ, Mark THOMPSON, Luis Jorge Camilo MARANGA, Simon Sheng-Tsiung HSU, Mridul GHOSH, Ajit SUBRAMANIAN
  • Method of purifying influenza virus and removing MDCK cell DNA contaminants
    Patent number: 8357376
    Abstract: The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.
    Type: Grant
    Filed: January 5, 2010
    Date of Patent: January 22, 2013
    Assignee: Memimmune, LLC
    Inventors: Jonathan Liu, Richard Schwartz, Mark Thompson, Luis Jorge Camilo Maranga, Simon Sheng-Tsiung Hsu, Mridul Ghosh, Ajit Subramanian
  • NON-TUMORIGENIC MDCK CELL LINE FOR PROPAGATING VIRUSES
    Publication number: 20120115206
    Abstract: The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.
    Type: Application
    Filed: January 20, 2012
    Publication date: May 10, 2012
    Applicant: Medlmmune Way
    Inventors: Richard Schwartz, John Michael Berry, Ajit Subramanian, Xiao Shi
  • Non-tumorigenic MDCK cell line for propagating viruses
    Patent number: 8119388
    Abstract: The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: February 21, 2012
    Assignee: Medimmune, LLC
    Inventors: Richard Schwartz, John Michael Berry, Ajit Subramanian, Xiao Shi
  • NON-TUMORIGENIC MDCK CELL LINE FOR PROPAGATING VIRUSES
    Publication number: 20100112000
    Abstract: The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.
    Type: Application
    Filed: January 13, 2010
    Publication date: May 6, 2010
    Applicant: MEDIMMUNE, LLC
    Inventors: Richard SCHWARTZ, John Michael Berry, Ajit SUBRAMANIAN, Xiao SHI
  • MDCK CELLS LINES SUPPORTING VIRAL GROWTH TO HIGH TITERS AND BIOREACTOR PROCESS USING THE SAME
    Publication number: 20100112669
    Abstract: The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.
    Type: Application
    Filed: January 5, 2010
    Publication date: May 6, 2010
    Applicant: MEDIMMUNE, LLC
    Inventors: Jonathan LIU, Richard SCHWARTZ, Mark THOMPSON, Luis Jorge Camilo MARANGA, Simon Sheng-Tsiung Hsu, Mridul GHOSH, Ajit SUBRAMANIAN
  • Non-tumorigenic MDCK cell line for propagating viruses
    Patent number: 7670837
    Abstract: The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: March 2, 2010
    Assignee: Medimmune, LLC
    Inventors: Richard Schwartz, John Michael Berry, Ajit Subramanian, Xiao Shi
  • MDCK CELL LINES SUPPORTING VIRAL GROWTH TO HIGH TITERS AND BIOREACTOR PROCESS USING THE SAME
    Publication number: 20080286850
    Abstract: The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.
    Type: Application
    Filed: September 14, 2007
    Publication date: November 20, 2008
    Applicant: MEDIMMUNE VACCINES, INC.
    Inventors: Jonathan Liu, Richard Schwartz, Mark Thompson, Luis Jorge Camilo Maranga, Simon Sheng-Tsiung Hsu, Mridul Ghosh, Ajit Subramanian
  • Non-tumorigenic MDCK cell line for propagating viruses
    Publication number: 20060188977
    Abstract: The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.
    Type: Application
    Filed: December 16, 2005
    Publication date: August 24, 2006
    Applicant: MEDIMMUNE VACCINES, INC.
    Inventors: Richard Schwartz, John Berry, Ajit Subramanian, Xiao Shi